公开(公告)号：US20240050426A1

公开(公告)日：2024-02-15

申请号：US18546245

申请日：2022-02-14

Applicant: The Cleveland Clinic Foundation

Inventor： Michaela Gack ,  Michiel van Gent

IPC: A61K31/4745 ,  A61K31/498 ,  A61K31/522 ,  A61K45/06 ,  A61P31/22

CPC classification number: A61K31/4745 ,  A61K31/498 ,  A61K31/522 ,  A61K45/06 ,  A61P31/22

Abstract: Provided herein are compositions, systems, and methods treating latent viral infection with an NMD inhibitor (e.g. to reactive the latent virus to lytic virus), in combination with an anti-viral agent. In certain embodiments, the latent viral infection is caused by EBV or KSHV. In other embodiments, cancer (e.g., caused by the virus) is treated by further administering an anti-cancer agent, such as an immunomodulatory agent.

公开(公告)号：US20240041798A1

公开(公告)日：2024-02-08

申请号：US18462648

申请日：2023-09-07

Applicant: The Cleveland Clinic Foundation

Inventor： Vincent K. Tuohy ,  Suparna Mazumder ,  Justin M. Johnson

IPC: A61K31/138 ,  A61K31/337 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/4745 ,  A61K31/675 ,  A61K31/502 ,  A61K31/7048 ,  A61K31/7064 ,  A61K31/4985 ,  A61K31/4196 ,  A61K45/06 ,  A61K31/704 ,  A61K33/243 ,  A61P35/00 ,  A61K39/00

CPC classification number: A61K31/138 ,  A61K31/337 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/4745 ,  A61K31/675 ,  A61K31/502 ,  A61K31/7048 ,  A61K31/7064 ,  A61K31/4985 ,  A61K31/4196 ,  A61K45/06 ,  A61K31/704 ,  A61K33/243 ,  A61P35/00 ,  A61K39/001102 ,  A61K2039/575 ,  A61K33/244

Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).

公开(公告)号：US11835503B2

公开(公告)日：2023-12-05

申请号：US17234229

申请日：2021-04-19

Applicant: The Cleveland Clinic Foundation

Inventor： Stanley L. Hazen ,  Zeneng Wang ,  Bruce S. Levison

IPC: G01N30/88 ,  C12Q1/18 ,  G01N33/68 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/7036 ,  G01N30/72 ,  C12Q1/02 ,  A61K31/496

CPC classification number: G01N30/88 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/496 ,  A61K31/7036 ,  C12Q1/025 ,  C12Q1/18 ,  G01N33/6893 ,  G01N30/7233 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases.

公开(公告)号：US11786489B2

公开(公告)日：2023-10-17

申请号：US17404025

申请日：2021-08-17

Applicant: The Cleveland Clinic Foundation

Inventor： Vincent K. Tuohy ,  Suparna Mazumder ,  Justin M. Johnson

IPC: A61K31/138 ,  A61K31/337 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/4745 ,  A61K31/675 ,  A61K31/502 ,  A61K31/7048 ,  A61K31/7064 ,  A61K31/4985 ,  A61K31/4196 ,  A61K45/06 ,  A61K31/704 ,  A61K33/243 ,  A61P35/00 ,  A61K39/00 ,  A61K33/244

CPC classification number: A61K31/138 ,  A61K31/337 ,  A61K31/4196 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/555 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7064 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/001102 ,  A61K45/06 ,  A61P35/00 ,  A61K33/244 ,  A61K2039/575 ,  A61K2300/00 ,  A61K31/555 ,  A61K2300/00 ,  A61K31/675 ,  A61K2300/00 ,  A61K31/704 ,  A61K2300/00 ,  A61K31/7048 ,  A61K2300/00 ,  A61K31/7068 ,  A61K2300/00 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/7064 ,  A61K2300/00 ,  A61K31/4985 ,  A61K2300/00

Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).

公开(公告)号：US20230285035A1

公开(公告)日：2023-09-14

申请号：US18120385

申请日：2023-03-11

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Guillermo Ortiz Blanco

IPC: A61B17/16

CPC classification number: A61B17/1635 ,  A61B2217/005

Abstract: A bone tissue collection device is provided with an exterior collection container and a porous interior filter container. The device includes a lid having an upper face and is configured to releaseably seal the exterior collection container and interior filter container. A suction inlet tube and a suction outlet tube are operably coupled to the lid and angled from the upper face of the lid.

公开(公告)号：US20230263998A1

公开(公告)日：2023-08-24

申请号：US18111138

申请日：2023-02-17

Applicant: The Cleveland Clinic Foundation

Inventor： Charles Martin, III ,  Mark A. Miller

IPC: A61M25/02 ,  A61B46/10 ,  A61M25/00

CPC classification number: A61M25/02 ,  A61B46/10 ,  A61M25/0009 ,  A61M2025/0253

Abstract: A medical assembly includes a sheath having a channel that extends therethrough; a medical device that extends into the channel of the sheath via a proximal end of the sheath; and a cover at least partially enclosing a space and having a first opening that provides access to the space, wherein the sheath extends through the first opening such that the medical device emerges from the proximal end of the sheath within the space.

公开(公告)号：US11696717B2

公开(公告)日：2023-07-11

申请号：US16676997

申请日：2019-11-07

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Mark J. Niebauer

IPC: A61B5/0452 ,  A61B5/0408 ,  A61B5/00 ,  G06N20/20 ,  A61B5/349 ,  A61B5/25

CPC classification number: A61B5/349 ,  A61B5/25 ,  A61B5/7225 ,  A61B5/7275 ,  G06N20/20

Abstract: Systems and methods are provided for evaluating infranodal pacing is applied to a patient. Electrocardiogram (ECG) data representing the pacing is obtained from a set of electrodes as an ECG lead. A predictor value representing a frequency content a portion of the ECG lead is extracted. A fitness parameter is determined for the pacing from at least the predictor value. The fitness parameter represents a likelihood that the applied infranodal pacing will induce left ventricular dysfunction in the patient. The fitness parameter is displayed to a user at an associated display.

公开(公告)号：US11691280B2

公开(公告)日：2023-07-04

申请号：US17157693

申请日：2021-01-25

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Robb Colbrunn ,  Tara Nagle ,  Callan Gillespie

IPC: B25J9/16 ,  B25J13/08

CPC classification number: B25J9/1633 ,  B25J9/1638 ,  B25J9/1653 ,  B25J9/1664 ,  B25J13/085 ,  B25J13/088 ,  B25J13/089

Abstract: An object can be moved via a robotic system with a combination of force and position control. The control system can include the object to be moved, the robotic system that moves the object, at least one force sensor, at least one position sensor, and a controller. A position control output, a force control output, and a hybrid weighting value can each be determined by the controller based on sensor data and then combined to determine an amount of position control and/or force control to be applied to move the object and/or modify an object in motion's trajectory.

公开(公告)号：US20230184804A1

公开(公告)日：2023-06-15

申请号：US18108738

申请日：2023-02-13

Applicant: The Cleveland Clinic Foundation ,  Parker Hannifin Corporation

Inventor： George F. Muschler ,  James K. Monnich ,  Edward J. Kwee ,  Kimerly A. Powell ,  Edward E. Herderick ,  Cynthia A. Boehm ,  Thomas R. Adams ,  Robert Germanoski ,  Frank Krakosh, III ,  James Dunn ,  Daniel Bantz

IPC: G01N35/10 ,  C12M1/36 ,  B01L9/00 ,  B01L3/02 ,  G01B11/06 ,  G01B11/14

CPC classification number: G01N35/1011 ,  C12M41/48 ,  B01L9/56 ,  B01L3/0262 ,  G01B11/0608 ,  G01B11/14 ,  B01L2300/0654 ,  G01N2035/1013

Abstract: Systems and methods provide for detection and controlled interaction with one or more objects. The system can include an imaging subsystem (20), a tool subsystem (26) containing one or more tools, a stage subsystem (16) and a control system (40). The control system (40) can integrate controls for each of the other subsystems, which controls can be implement desired functions over a variety of process parameters to perform the controlled interaction.

公开(公告)号：US20230146428A1

公开(公告)日：2023-05-11

申请号：US17984624

申请日：2022-11-10

Applicant: Case Western Reserve University ,  The Cleveland Clinic Foundation

Inventor： Anant Madabhushi ,  Golnoush Asaeikheybari ,  Amogh Hiremath ,  Mina K. Chung ,  John Barnard

IPC: G06T7/33 ,  G06V10/44 ,  G06V10/764 ,  G06T7/00

CPC classification number: G06T7/33 ,  G06T7/0016 ,  G06V10/44 ,  G06V10/764 ,  G06T2207/10081 ,  G06T2207/20224 ,  G06T2207/30041 ,  G06T2207/30048 ,  G06T2207/30061 ,  G06T2207/30096 ,  G06T2207/30101

Abstract: Systems, methods, and apparatus are provided for generating an atlas image of a branched structure and predicting a likelihood of success of certain treatments based on the atlas image. In one example, a method includes registering a plurality of images of instances of a branched structure to generate an aligned image for a cohort, wherein the branched structure comprises a central structure and at least one primary branch connected to the central structure; for each primary branch of the branched structure, iteratively registering respective portions of a plurality of images containing the primary branch to generate an aligned image portion of the primary branch; and applying a control grid of the aligned image portion of the primary branch to respective image portions containing the central structure and the other primary branches prior to iteratively registering a next primary branch; and generating an atlas image for the cohort based on the aligned image portions.