-
公开(公告)号:US08832088B1
公开(公告)日:2014-09-09
申请号:US13562098
申请日:2012-07-30
Applicant: Zhihui Chen , Cheng Zhu
Inventor: Zhihui Chen , Cheng Zhu
CPC classification number: G06F17/30864 , G06F17/30675 , G06F17/30867 , G06Q30/00 , G06Q30/02
Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for ranking search results. One of the methods includes receiving a search result obtained in response to a query. A recent impression probability for the query for a recent time period and an overall impression probability for the query for an overall time period are computed. A ratio QtoA of the recent impression probability to the overall impression probability is computed. A determination is made that users prefer newer resources over older resources for the query based on QtoA and that the resource is a new resource. A new score S′ is associated with the resource in place of S, wherein the new score S′ signifies a better result than the score S signifies, based on determining that users prefer newer resources over older resources for the query, and that the resource is a new resource.
Abstract translation: 方法,系统和装置,包括在计算机存储介质上编码的计算机程序,用于对搜索结果进行排名。 其中一种方法包括接收响应于查询而获得的搜索结果。 计算最近时间段的查询的最近的展示概率和整个时间段的查询的总体展示概率。 计算出最近的印象概率与整体印象概率的比值QtoA。 确定用户根据QtoA的查询优先选择较旧的资源,资源是新的资源。 新的分数S'与资源相关联,代替S,其中新分数S'表示比分数S表示更好的结果,这基于确定用户喜欢比较旧的资源更新的资源用于查询,并且资源 是一个新的资源。
-
22.
公开(公告)号:US08604038B2
公开(公告)日:2013-12-10
申请号:US13392282
申请日:2010-08-24
Applicant: Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gergori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
Inventor: Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gergori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
IPC: A61K31/50 , A61K31/525
CPC classification number: C07D401/12 , C07D207/08 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)的化合物,其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
-
23.Compositions and methods for imparting a sunless tan with functionalized adjuvants 有权
Title translation: 用功能化佐剂赋予无阳光棕褐色的组合物和方法公开(公告)号:US08398959B2
公开(公告)日:2013-03-19
申请号:US13305961
申请日:2011-11-29
Applicant: Xiaoxia Yang , Jun-Cheng Zhu
Inventor: Xiaoxia Yang , Jun-Cheng Zhu
IPC: A61K8/00
CPC classification number: A61K8/4913 , A61K8/35 , A61K8/492 , A61Q19/04
Abstract: Described are compositions and methods for imparting a sunless tan with functionalized adjuvants and a tanning agent like dihydroxyacetone. The functionalized adjuvants are pyrrole and/or indole derivatives functionalized with a substituent comprising a carbonyl group.
Abstract translation: 描述了用功能化佐剂和鞣制剂如二羟基丙酮赋予无阳光褐变的组合物和方法。 功能化佐剂是用包含羰基的取代基官能化的吡咯和/或吲哚衍生物。
-
24.NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权
Title translation: 新型吡咯烷衍生的BETA 3 ADRENERGIC RECEPTOR AGONISTS公开(公告)号:US20120225886A1
公开(公告)日:2012-09-06
申请号:US13392282
申请日:2010-08-24
Applicant: Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gregori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
Inventor: Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gregori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
IPC: A61K31/501 , A61K31/4196 , C07D401/12 , A61K31/4439 , A61K31/506 , A61K31/497 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , C07D471/04 , A61K31/437 , C07D207/04 , A61K31/40 , A61P13/10 , A61P13/02 , C07D403/12
CPC classification number: C07D401/12 , C07D207/08 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)化合物,其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
-
25.SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权
Title translation: 取代的环状化合物,包含这些化合物的组合物和处理方法公开(公告)号:US20140057893A1
公开(公告)日:2014-02-27
申请号:US14110332
申请日:2012-04-05
Applicant: Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
Inventor: Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC: C07D513/04 , C07D413/14 , C07D413/04 , C07D498/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D211/22
CPC classification number: C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
Abstract: Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
Abstract translation: 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法
-
26.Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists 有权
Title translation: 羟甲基吡咯烷作为β3肾上腺素能受体激动剂公开(公告)号:US08653260B2
公开(公告)日:2014-02-18
申请号:US13527934
申请日:2012-06-20
Applicant: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Ding-Ming Shen , Liping Wang , Cheng Zhu
Inventor: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Ding-Ming Shen , Liping Wang , Cheng Zhu
IPC: C07D253/08 , C07D487/04 , C07D495/04 , C07D239/80 , C07D241/12 , C07D265/06 , C07D237/14 , C07D237/16 , C07D237/32 , A61P13/06
CPC classification number: C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)的化合物,其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
-
27.Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists 有权
Title translation: 羟甲基吡咯烷作为β3肾上腺素能受体激动剂公开(公告)号:US08501786B2
公开(公告)日:2013-08-06
申请号:US12936275
申请日:2009-03-23
Applicant: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
Inventor: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Bart Harper , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC: A61K31/443 , A61K31/4436 , A61K31/4439 , C07D401/14 , C07D413/14 , C07D417/14
CPC classification number: C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式I化合物,其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。
-
28.Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists 有权
Title translation: 羟甲基吡咯烷作为β3肾上腺素能受体激动剂公开(公告)号:US08399480B2
公开(公告)日:2013-03-19
申请号:US12936221
申请日:2009-04-02
Applicant: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
Inventor: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC: A61K43/90 , A01K31/44 , C07D237/00
CPC classification number: C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)化合物,其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
-
29.
公开(公告)号:US08354403B2
公开(公告)日:2013-01-15
申请号:US13392662
申请日:2010-08-17
Applicant: Scott D. Edmondson , Richard Berger , Lehua Chang , Vincent J. Colandrea , Jeffrey J. Hale , Bart Harper , Nam Fung Kar , Bing Li , Greg J. Morriello , Christopher R. Moyes , Deyou Sha , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
Inventor: Scott D. Edmondson , Richard Berger , Lehua Chang , Vincent J. Colandrea , Jeffrey J. Hale , Bart Harper , Nam Fung Kar , Bing Li , Greg J. Morriello , Christopher R. Moyes , Deyou Sha , Dong-Ming Shen , Liping Wang , Harvey Wendt , Cheng Zhu
IPC: A61K31/536 , A61K31/438 , A61K31/4245 , C07D265/12 , C07D221/20 , C07D413/14
CPC classification number: C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)化合物,其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
-
30.HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权
Title translation: 羟丙基吡咯烷酮作为3型ADRENERGIC受体激动剂公开(公告)号:US20120258963A1
公开(公告)日:2012-10-11
申请号:US13527934
申请日:2012-06-20
Applicant: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
Inventor: Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC: A61K31/41 , C07D403/12 , C07D413/12 , A61K31/427 , A61K31/428 , A61P13/00 , A61K31/416 , A61K31/4178 , A61K31/502 , A61K31/53 , A61K31/5355 , A61P13/10 , C07D417/12 , A61K31/4192
CPC classification number: C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
Abstract translation: 本发明提供式(I)化合物,其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
-
-
-
-
-
-
-
-
-