Abstract:
An implantable device for positioning in the vicinity of the bifurcation of the common carotid artery (CCA) into the internal carotid artery (ICA) and the external carotid artery (ECA), comprises a deflecting element suitable to deflect the flow of embolic material flowing in the CCS toward the ICA, into the ECA, without filtering.
Abstract:
An implantable filtering device for implanting within an artery supplying blood to the brain, the device being made of bio-compatible material and comprising a filtering unit for entrapping plaque debris, and an anchoring member engageable with the walls of the carotid artery for anchoring said filtering unit at a fixed location with the artery. The filtering unit has a tapering shape extending between a wide inlet portion and a narrower outlet portion extending downstream, and a tap element fitted at the outlet portion for entrapping plaque debris.
Abstract:
A process for preparing a compound of formula (II): ##STR1## or a tautomer or salt thereof in substantially pure form wherein R.sup.1 is C.sub.1-6 alkyl optionally substituted by one or more halogen atoms; R.sup.3 is hydrogen, fluorine, chlorine, bromine or iodine, C.sub.1-6 alkyl, trifluoromethyl or a cyano group; R.sup.4 is hydrogen, fluorine, chlorine, bromine, iodine or trifluoromethyl; R.sup.5 is fluorine, chlorine, bromine, iodine or trifluoromethyl; and R.sup.6 is hydrogen or C.sub.1-4 alkyl; which process comprises nitrating a compound of formula (III): ##STR2## or a salt thereof wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined above, in a solvent which is resistant to nitration under the desired reaction conditions and suitable for purification of the product of formula (II), heating the resultant solution to a temperature sufficient to at least partially dissolve the desired product and impurities and cooling the solution to precipitate the compound of formula (II) in substantially pure form.
Abstract:
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
Abstract:
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
Abstract:
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
Abstract:
System for improving a performance estimation of an operator of a vehicle, comprising a first module implementing a first method for estimating a performance state of vehicle operation, a second module implementing a second method for estimating at least one of a physiological and behavioural state of the operator, a device for sharing an estimated state between one of the first and the second module and the other one of the first and the second module, wherein the implemented estimation method of one of the first and the second module is adjusted based on the state of the other one of the first and the second module, thereby improving the estimation of at least one of the performance state of vehicle operation and the physiological and/or behavioural state of the operator.
Abstract:
The present invention generally relates to a method, a system and/or a computer readable program. An embodiment of the method includes acquiring an input signal indicative of the operator's expectation of the state of the object at a first point in time; determining a state of the object at a second later point in time based on the input signal; acquiring an input signal indicative of an estimated visual input of the operator at the second point in time; determining the operator's expectation of the state at the second point in time, based on the operator's expectation of the state of the object at the first point in time, and the estimated visual input and the state of the object at the second point in time; and providing an output signal indicative of the operator's expectation of the state at the second point in time.
Abstract:
The present invention relates to a method for determining a vehicle operator's visual input of an object in the operator's surroundings, which method comprises receiving an object position signal indicative of the position of at least one object, receiving an operator motion input signal indicative of operator physiological data comprising information relating to body motion of the operator, estimating an operator eye-gaze direction, and determining a visual input quality value representative of level of visual input of the at least one object received by the operator, based on the object position signal and the estimated operator eye-gaze direction.