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公开(公告)号：US20150322405A1
公开(公告)日：2015-11-12
申请号：US14364200
申请日：2012-12-13
发明人： Yanchuang Han , Xin-Fu Zhou
IPC分类号： C12N5/0797 , C12N5/0793 , C12N5/079
CPC分类号： C12N5/0623 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2501/065 , C12N2501/40 , C12N2501/72 , C12N2501/727 , C12N2501/999 , C12N2506/1307 , G01N33/5073
摘要： The present invention provides a method of producing a multipotent stem cell, said method comprising culturing at least one fibroblast cell in the presence of an effective amount of at least one small molecule reprogramming factor(s) that induces the cell to de-differentiate into a multipotent stem cell, wherein the method excludes the use of reprogramming factor(s) that are not small molecules. The small molecule reprogramming factor(s) may include a G9a HMTase inhibitor(s) and/or a MEK inhibitor(s) optionally in combination with other small molecule reprogramming factor(s). The invention also includes methods of differentiating the multipotent stem cells, cells produced by the methods, assays using the cells and kits for use in the methods.
摘要翻译： 本发明提供了一种产生多能干细胞的方法，所述方法包括在存在有效量的至少一种小分子重编程因子的情况下培养至少一种成纤维细胞，所述小分子重编程因子诱导细胞脱分化为 多能干细胞，其中该方法不包括使用不是小分子的重编程因子。 小分子重编程因子可以包括任选与其它小分子重编程因子组合的G9a HMTase抑制剂和/或MEK抑制剂。 本发明还包括区分多能干细胞，通过该方法产生的细胞，使用细胞的测定法和用于该方法的试剂盒的方法。
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公开(公告)号：US20230071171A1
公开(公告)日：2023-03-09
申请号：US17869356
申请日：2022-07-20
摘要： The present invention relates to methods for enhancing at least one growth parameter of a leguminous plant via co-inoculation of a leguminous plant with at least one rhizobial microorganism together with at least one actinobacterial microorganism. In further aspects, the present invention also relates to leguminous plants co-inoculated with at least one rhizobial microorganism together with at least one actinobacterial microorganism, as well as specific actinobacterial strains and inoculant compositions which are useful in accordance with the present invention.
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23.发明申请公开(公告)号：US20230002502A1
公开(公告)日：2023-01-05
申请号：US17779908
申请日：2020-11-26
申请人： South Australian Health and Medical Research Institute Limited , The Flinders University of South Australia
摘要： The present disclosure relates to methods and products for reducing side effects associated with immunotherapy using immune agonist antibodies. In certain embodiments, the present disclosure provides a method of reducing one or more side effects associated with immunotherapy using an immune agonist antibody alone, or in combination with an immune checkpoint inhibitor, in a subject suffering from a cancer, the method comprising modifying the gut microbiota in the subject and thereby reducing the one or more side effects associated with the immunotherapy in the subject.
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公开(公告)号：US20210213053A1
公开(公告)日：2021-07-15
申请号：US17059221
申请日：2019-05-29
IPC分类号： A61K33/34 , A61K33/30 , A61K47/38 , A61K47/10 , A61K9/08 , A61K9/14 , A61K9/06 , A61B17/43 , A61B17/435
摘要： A method of enhancing embryo implantation in a subject is disclosed which comprises administering to the uterine cavity of the subject a formulation comprising copper and/or zinc in an amount effective to stimulate endometrial production of leukaemia inhibitory factor (LIF) and/or vascular endothelial growth factor (VEGF). Alternatively, a device may be inserted into the uterine cavity of the subject, wherein the device comprises copper and/or zinc, for a period of time that is effective to stimulate endometrial production of LIF and/or VEGF. The method is suitable for use with women undergoing treatment by any of the assisted reproductive technologies, such as those involving the transfer of embryos such as in vitro fertilisation (IVF) and variants including IVF-ICSI (intracytoplasmic sperm injection) and in vitro maturation (IVM) treatments, as well as intrauterine-insemination (IUI) therapy. However, the method is also applicable for women wanting to improve their prospects of pregnancy through natural conception.
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25.发明授权公开(公告)号：US10647621B2
公开(公告)日：2020-05-12
申请号：US15780078
申请日：2016-11-30
申请人： Adelaide Research and Innovation , Flinders University of South Australia , University of Canterbury , University of South Australia
IPC分类号： C07C1/12 , B01J23/52 , C07C29/157 , B01J21/06 , B01J21/18 , B01J23/46 , B01J35/00 , B01J31/22 , B01J23/42 , B01J31/24 , C10G2/00 , C01B3/04 , B01J37/16 , C01B3/06 , C07C9/04 , C07C31/04 , B01J37/03
摘要： A method for the production of hydrocarbon(s), such as methane, substituted hydrocarbons, such as methanol, or the production of hydrogen, the method comprising the steps of contacting a first catalyst with water in order to photocatalyse the splitting of at least some of the water into hydrogen and oxygen; and contacting a second catalyst with a gas stream comprising carbon dioxide and at least some of the hydrogen produced from step (a) in order to photocatalyse the reaction between the hydrogen and carbon dioxide to produce hydrocarbon(s), such as methane, and/or substituted hydrocarbons, such as methanol. In an embodiment, the catalyst comprises gold and or ruthenium nanoclusters supported on a substrate.
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公开(公告)号：US10596187B2
公开(公告)日：2020-03-24
申请号：US15034965
申请日：2014-11-07
IPC分类号： A61K33/00 , A23L2/38 , A61K31/718 , A61K33/14 , A61K47/36 , A61K9/00 , A23L2/52 , A61K33/30 , A61K33/34 , A61K33/06 , A23L33/105 , A23L33/16 , A23L29/212 , A23L33/10 , A23L33/21 , A23L29/269 , A23L29/238 , A23L29/256 , A23L29/231 , A23L29/25 , A23L29/281 , A61K31/194 , A61K31/7004
摘要： Provided herein are compositions, for example: oral rehydration compositions, beverages, food items, methods and uses, which utilise resistant starch to prevent or treat dehydration, including dehydration which is caused by diarrhoea. Beverages, food items and oral rehydration solutions including a resistant starch, which are suitable for aiding in the maintenance and restoration of hydration levels in individuals undertaking physical activities, including sports, are also disclosed.
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公开(公告)号：US10590012B2
公开(公告)日：2020-03-17
申请号：US15521099
申请日：2015-10-13
IPC分类号： B01J20/22 , C02F1/28 , C07C319/22 , B01J20/30 , B01J20/26 , B01J20/32 , C07C321/22 , C02F101/20 , C02F103/00 , C02F101/10
摘要： Disclosed is a limonene-sulfur polysulfide and methods for preparing the same. The polysulfide prepared according to these methods is flexible, moldable and otherwise capable of being formed in any manner consistent with a thermoplastic polymer. The limonene-sulfur polysulfide has been demonstrated to sequester inorganic palladium and inorganic mercury dissolved in water.
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公开(公告)号：US20200045979A1
公开(公告)日：2020-02-13
申请号：US16608421
申请日：2018-04-27
摘要： The present disclosure relates to bacterial inoculants, and methods for their use, to control a fungal root disease in a plant and promote plant growth in water limited conditions. In particular strains of Paenibacillus and Streptomyces are disclosed.
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公开(公告)号：US20140350222A1
公开(公告)日：2014-11-27
申请号：US14352346
申请日：2012-10-19
摘要： Disclosed herein is a process for extracting lipid containing products from microalgal biomass, the process comprising: (i) treating an aqueous mixture comprising microalgal biomass with microwave radiation and (ii) recovering lipid containing products from the treated microalgal biomass.
摘要翻译： 本文公开了一种从微藻生物质中提取含有脂质的产品的方法，该方法包括：（i）用微波辐射处理包含微藻生物质的含水混合物，和（ii）从经处理的微藻生物质中回收含脂质的产物。
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