公开(公告)号：US20090111969A1

公开(公告)日：2009-04-30

申请号：US12341683

申请日：2008-12-22

Applicant: Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

Inventor： Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

IPC: C07K5/00

CPC classification number: C07K5/0804

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：US20090105471A1

公开(公告)日：2009-04-23

申请号：US12341971

申请日：2008-12-22

Applicant: Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

Inventor： Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

IPC: C07D225/04 ,  C07D245/04

CPC classification number: C07K5/0804

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：US20080306050A1

公开(公告)日：2008-12-11

申请号：US12064196

申请日：2006-08-17

Applicant: George A. Doherty ,  Zachary Jones

Inventor： George A. Doherty ,  Zachary Jones

IPC: A61K31/5513 ,  C07D243/14 ,  A61P37/02

CPC classification number: C07D243/20

Abstract: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract translation: 提供了可用于通过Toll样受体TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫，炎症过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

公开(公告)号：US20160137608A1

公开(公告)日：2016-05-19

申请号：US14881906

申请日：2015-10-13

Applicant: James Jeffry Howbert ,  Gregory N. Dietsch ,  Robert Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachery Jones

Inventor： James Jeffry Howbert ,  Gregory N. Dietsch ,  Robert Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachery Jones

IPC: C07D223/16 ,  C07D401/04 ,  C07D403/10 ,  C07D403/04 ,  C07D403/06 ,  C07D401/12

CPC classification number: C07D223/16 ,  A61K31/4025 ,  A61K31/55 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。

公开(公告)号：US20140088085A1

公开(公告)日：2014-03-27

申请号：US13979634

申请日：2012-01-12

Applicant: Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones ,  James Jeffry Howbert ,  Robert Hershberg ,  Joseph P. Lyssikatos ,  Hong Woon Yang

Inventor： Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones ,  James Jeffry Howbert ,  Robert Hershberg ,  Joseph P. Lyssikatos ,  Hong Woon Yang

IPC: C07D223/16 ,  C07D243/14 ,  C07D487/04 ,  C07D401/12

CPC classification number: C07D223/16 ,  C07D243/14 ,  C07D401/12 ,  C07D487/04

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。

公开(公告)号：US08586754B2

公开(公告)日：2013-11-19

申请号：US12793418

申请日：2010-06-03

Applicant: Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

IPC: C07D209/32 ,  C07D401/10

CPC classification number: C07D215/14 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/20 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D309/08 ,  C07D309/14 ,  C07D309/32 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08580794B2

公开(公告)日：2013-11-12

申请号：US12951344

申请日：2010-11-22

Applicant: George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Andrew J. Souers ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Robert Mantei ,  Todd M. Hansen

Inventor： George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Andrew J. Souers ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Robert Mantei ,  Todd M. Hansen

IPC: A61K31/407 ,  C07D401/12

CPC classification number: C07D471/04 ,  C07D491/052 ,  C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08563735B2

公开(公告)日：2013-10-22

申请号：US12631404

申请日：2009-12-04

Applicant: Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt

IPC: C07D401/10 ,  C07D213/62 ,  C07D307/02

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20110118235A1

公开(公告)日：2011-05-19

申请号：US12859182

申请日：2010-08-18

Applicant: James Jeffry Howbert ,  Gregory Dietsch ,  Robert Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones

Inventor： James Jeffry Howbert ,  Gregory Dietsch ,  Robert Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones

IPC: A61K31/55 ,  C07D403/10 ,  A61P37/02

CPC classification number: C07D223/16 ,  A61K31/4025 ,  A61K31/55 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。

公开(公告)号：US20110105463A1

公开(公告)日：2011-05-05

申请号：US13001201

申请日：2009-06-24

Applicant: Laurence E. Burgess ,  Christopher T. Clark ,  Adam Cook ,  Christopher P. Corrette ,  Robert Kirk DeLisle ,  George A. Doherty ,  Kevin W. Hunt ,  Todd T. Romoff

Inventor： Laurence E. Burgess ,  Christopher T. Clark ,  Adam Cook ,  Christopher P. Corrette ,  Robert Kirk DeLisle ,  George A. Doherty ,  Kevin W. Hunt ,  Todd T. Romoff

IPC: A61K31/397 ,  C07D311/02 ,  A61K31/352 ,  C07D405/12 ,  A61K31/4025 ,  C07D403/12 ,  A61K31/453 ,  A61K31/506 ,  A61K31/4725 ,  A61P37/00

CPC classification number: C07D311/58 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

Abstract translation: 式（I）化合物：其中A1，A2，W，L，G，R7a，R7b，R8，R9和R10具有本说明书中给出的含义，是可用于治疗免疫疾病的DP2受体调节剂。