公开(公告)号：US09901953B2

公开(公告)日：2018-02-27

申请号：US15006710

申请日：2016-01-26

申请人： Heraeus Medical GmbH

发明人： Sebastian Vogt

IPC分类号： B67D7/70 ,  B05C17/005 ,  B05C17/015 ,  B05C17/01 ,  A61B17/88

CPC分类号： B05C17/00553 ,  A61B17/8816 ,  A61B17/8822 ,  A61B2017/8838 ,  B05C17/00503 ,  B05C17/00513 ,  B05C17/00559 ,  B05C17/00576 ,  B05C17/0146 ,  B05C17/015

摘要： A paste application device stores two starting components, for mixing the starting components to form a paste and for the application of the paste. The comprises a two-component cartridge comprising two cylindrical internal spaces, two feed plungers that can be shifted axially in the internal spaces and limit the internal spaces on a first side of the two-component cartridge, and at least two dispensing openings by means of which the internal spaces are open on a second side of the two-component cartridge that is opposite from the first side, a hollow cylinder that is made of a plastic material and has one front face that is open and one front face that is partially closed, in which is situated an axially mobile plunger that has two pestles attached to it, whereby the pestles are oriented in the direction of the open front face, whereby the open front face of the hollow cylinder is arranged to axially touch against the first side of the two-component cartridge, and whereby the plunger closes in gas-tight manner against the internal walls of the hollow cylinder, whereby the two-component cartridge and the hollow cylinder are arranged in a pressure vessel, whereby the pressure vessel touches against the hollow cylinder or is situated at a distance from the hollow cylinder of at most 0.1 mm.

公开(公告)号：US20180021075A1

公开(公告)日：2018-01-25

申请号：US15656369

申请日：2017-07-21

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61B17/88 ,  A61L27/50 ,  B01F15/00 ,  B01F3/10 ,  B01F5/06 ,  B01F13/00 ,  B01F13/10 ,  A61L27/16 ,  B01F15/02

摘要： Bone cement applicators and methods apply a bone cement dough in the region of the spine. The applicators and method have at least one tubular cartridge with an internal space, containing starting components of the bone cement, at least one dispensing plunger that is mobile in longitudinal direction on the inside of the at least one cartridge, a hose, an application opening through which the bone cement dough is applicable, a three-way valve being arranged in the hose or on a side of the hose facing the at least one cartridge and in fluid connection with the opening of the at least one cartridge and/or a collecting container arranged on the three-way valve for accommodation of bone cement dough. The three-way valve is appropriately designed and/or arranged in the bone cement applicator such that it, being in a first position, provides a fluid connection between the application opening and the opening of the at least one cartridge and closes a passage to the collecting container and, being in a second position, provides a fluid connection between the application opening and the collecting container and closes a passage to the opening of the at least one cartridge.

公开(公告)号：US20170348457A1

公开(公告)日：2017-12-07

申请号：US15615209

申请日：2017-06-06

申请人： HERAEUS MEDICAL GMBH

发明人： SEBASTIAN VOGT ,  THOMAS KLUGE

IPC分类号： A61L24/00 ,  A61L24/04

CPC分类号： A61L24/0021 ,  A61L24/001 ,  A61L24/043 ,  A61L24/06 ,  A61L27/16 ,  A61L2430/02 ,  C08F265/06 ,  C08L33/12 ,  C08F220/14 ,  C08F2222/1013

摘要： A pasty two-component polymethacrylate bone cement comprising a pasty component A, containing AI at least one distillable methacrylate monomer for radical polymerisation; AII at least one polymer soluble in AI; AIII at least one particulate polymer with a particle size of no more than 500 μm that is not soluble in AI; AIV at least one radical stabiliser; and AV at least one aromatic amine accelerator; and a pasty component B, containing BI dibenzoyl peroxide; BII at least one substance that is not subject to radical polymerisation and is liquid at room temperature, whereby the solubility of dibenzoyl peroxide in this substance at room temperature is less than 5.0% by weight and, whereby the weight fraction of liquid substance BII in the self-curing cement dough is less than 2.0% by weight. Also disclosed is a method for producing a self-curing bone cement dough using the pasty two-component polymethacrylate bone cement.

公开(公告)号：US20170291153A1

公开(公告)日：2017-10-12

申请号：US15479919

申请日：2017-04-05

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： B01F7/16 ,  A61B17/88 ,  B01F7/20 ,  B01F3/12 ,  B01F15/02 ,  B01F15/00

CPC分类号： B01F7/161 ,  A61B17/8833 ,  A61B2017/8838 ,  B01F3/1221 ,  B01F7/20 ,  B01F11/0082 ,  B01F13/0033 ,  B01F15/0087 ,  B01F15/00974 ,  B01F15/0206 ,  B01F15/0237 ,  B01F15/0258 ,  B01F15/0278 ,  B01F15/0279 ,  B01F2215/0029

摘要： A device mixes bone cement and stores parent components of the bone cement. The device has a cartridge comprising an interior, that is closed on one side by a movable delivery plunger, a receptacle comprising side walls for receiving a monomer liquid container that are closed at least in some regions. The receptacle has at least one deformable closed side wall, a screen and/or a filter arranged below the receptacle so that the contents of the opened monomer liquid container flow through the screen and/or the filter. The device further has a connecting line through which the monomer liquid is to be routed into the interior of the cartridge, a hollow cylinder which is connected to the connecting line and which is connected to the receptacle by way of a fluid connection so that the hollow cylinder is arranged in a fluid line between the receptacle and the interior of the cartridge. A pump plunger is arranged in the hollow cylinder, which is axially displaceable in the hollow cylinder, and an opening device, which is movably mounted against the deformable side wall of the receptacle. The opening device extends into the hollow cylinder, wherein, by pressing the pump plunger into the hollow cylinder, the opening device is to be pressed against the deformable side wall of the receptacle so that the deformable side wall deforms such that a monomer liquid container located in the receptacle is to be opened by the pressure of the opening device.

公开(公告)号：US09700657B2

公开(公告)日：2017-07-11

申请号：US14337492

申请日：2014-07-22

申请人： HERAEUS MEDICAL GMBH ,  MEDIZINISCHE UNIVERSITÄT GRAZ

发明人： Klaus-Dieter Kühn ,  Annelie Weinberg ,  Peter Uggowitzer ,  Sebastian Vogt ,  Jörg Löffler

IPC分类号： A61L31/12 ,  A61F2/88 ,  A61L27/04 ,  A61L27/54 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16 ,  C22C21/06

CPC分类号： A61L31/124 ,  A61F2/885 ,  A61F2220/005 ,  A61L27/047 ,  A61L27/54 ,  A61L27/58 ,  A61L31/028 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/206 ,  A61L2300/23 ,  A61L2300/406 ,  A61L2300/414 ,  C22C21/06

摘要： The invention relates to a composite material that comprises at least one magnesium component, whereby the magnesium component consists of pure magnesium or a magnesium-calcium alloy or a magnesium-calcium-X alloy, whereby X is another biodegradable element. The composite material also contains at least one organic anti-infective agent having a solubility in water at room temperature of less than 10 grams per liter.

公开(公告)号：US20170173192A1

公开(公告)日：2017-06-22

申请号：US15375666

申请日：2016-12-12

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61L2/00 ,  A61K47/12 ,  A61K47/02 ,  A61K47/36

CPC分类号： A61L2/0082 ,  A61K47/02 ,  A61K47/12 ,  A61K47/36 ,  A61L2202/21 ,  C08B11/02 ,  C08B11/12 ,  C08B37/0072 ,  C08L1/284 ,  C08L1/286 ,  C08L3/08 ,  C08L5/00 ,  C08L5/08

摘要： Sterilization method according to which an aqueous polysaccharide solution is stored in the presence of a lactone and a buffer system for a period of at least 24 hours, and a sterile polysaccharide solution produced in this way.

公开(公告)号：US20170128113A1

公开(公告)日：2017-05-11

申请号：US15287789

申请日：2016-10-07

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61B17/88 ,  B05C17/005

CPC分类号： A61B17/8822 ,  A61B17/8819 ,  A61B17/8833 ,  A61B2017/8838 ,  B05C17/00503 ,  B05C17/00559 ,  B05C17/00573 ,  B05C17/00576 ,  B05C17/0146 ,  B05C17/015

摘要： A paste application device stores two starting components for mixing the starting components to form a paste and for application of the formed paste. The device comprises a two-component cartridge comprising two internal spaces, two feed plungers shiftable in the internal spaces and bordering the internal spaces on a first side of the two-component cartridge, and at least two dispensing openings by means of which the internal spaces are open on a second side of the two-component cartridge that is opposite from the first side. The device further comprises a hollow cylinder that is made of a plastic material and has one front face that is open and one front face that is partially closed, in which is situated an axially mobile plunger that has at least two pestles attached to it, wherein the at least two pestles are oriented in the direction of the open front face, wherein the open front face of the hollow cylinder is arranged to axially touch against the first side of the two-component cartridge, and a connector for a compressed gas cartridge extends through an opening in the pressure vessel wherein a flap valve can be used to regulate the volume flow of the starting components through the dispensing openings, and whereby the flap valve is operable by means of a rod assembly of the paste application device, whereby the rod assembly is supported with a clearance of at least 0.3 mm in at least one direction that is perpendicular to the main direction.

公开(公告)号：US09622866B2

公开(公告)日：2017-04-18

申请号：US14190819

申请日：2014-02-26

申请人： Heraeus Medical GmbH

发明人： Sebastian Vogt

IPC分类号： A61F2/38 ,  A61F2/30 ,  A61F2/46

CPC分类号： A61F2/385 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30224 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/30878 ,  A61F2002/4631 ,  A61F2240/001 ,  A61F2310/00353 ,  Y10T29/49

摘要： The invention relates to a knee spacer for temporary replacement of an artificial knee joint, whereby the knee spacer comprises a tibial component and a femoral component as separate components, which can be moved with respect to each other when inserted in a patient, and whereby the tibial component and the femoral component each comprise at least one running surface by means of which the tibial component and the femoral component can be placed against each other such as to be mobile in their patient-inserted state, and the tibial component comprises an anchoring surface that is arranged opposite to the running surface side and is provided for connecting the tibial component to the tibia by means of a bone cement, and the femoral component to comprise an anchoring surface that is arranged opposite to the running surface side and is provided for connecting the femoral component to the femur, whereby the tibial component and the femoral component each comprise at least two recesses that extend from the anchoring surface towards the running surface side into the running surface side, whereby the openings of the recesses are arranged appropriately in the running surface side of the components such that they do not slide over the running surface of the respective other component during articulation of the knee spacer.The invention also relates to a method for the manufacture of a knee spacer, in which the tibial component and the femoral component are produced as separate components and in which at least two recesses are formed in the tibial component and at least two recesses are formed in the femoral component, as well as to the use of said knee spacer as temporary spacer in a knee of a patient.

公开(公告)号：US20170072093A1

公开(公告)日：2017-03-16

申请号：US15259495

申请日：2016-09-08

申请人： HERAEUS MEDICAL GMBH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61L24/06 ,  A61L24/00 ,  A61L24/04

CPC分类号： A61L24/06 ,  A61L24/001 ,  A61L24/043 ,  A61L2430/02 ,  C08L33/12

摘要： A polymerizable polymethylmethacrylate bone cement, in which the initial viscosity of the cement dough can be controlled. The polymerizable bone cement composition comprises a monomer for radical polymerization, a powdered polymethylmethacrylate-co-polymer soluble in the monomer or a mixture comprising polymethylmethacrylate-co-polymers, a polymerization initiator, and a radiopaquer, wherein the powdered polymethylmethacrylate-co-polymer comprises at least one particulate polymethylmethacrylate-co-polymer having a molar mass of more than or equal to 200,000 g/mol, and the polymethylmethacrylate-co-polymer is obtainable by polymerization of a mixture of 90.0% or more by weight methylmethacrylate and 10.0% or less by weight of one or more comonomers, wherein the weight ratio of component A comprising the polymethylmethacrylate-co-polymer, radiopaquer, and polymerization initiator, and component B comprising a monomer for radical polymerization, stabiliser, and polymerization accelerator, is approximately 2.0 to 3.4 to 1.0, for controlling the initial viscosity of the bone cement dough formed by mixing components A and B.

摘要翻译： 可聚合的聚甲基丙烯酸甲酯骨水泥，其中可以控制水泥面团的初始粘度。 可聚合骨水泥组合物包括用于自由基聚合的单体，可溶于单体的粉末状聚甲基丙烯酸甲酯共​​聚物或包含聚甲基丙烯酸甲酯共​​聚物，聚合引发剂和放射线吸收剂的混合物，其中粉末状聚甲基丙烯酸甲酯共​​聚物包含 摩尔质量大于或等于200,000g / mol的至少一种聚甲基丙烯酸甲酯 - 共聚物和聚甲基丙烯酸甲酯共​​聚物可通过聚合甲基丙烯酸甲酯90.0％或更多的混合物和10.0％ 较少量的一种或多种共聚单体，其中包含聚甲基丙烯酸甲酯 - 共聚物，放射性聚合物和聚合引发剂的组分A和包含用于自由基聚合的单体的组分B，稳定剂和聚合促进剂的重量比为约2.0至 3.4至1.0，用于控制通过混合组合物形成的骨水泥面团的初始粘度 N和A

公开(公告)号：US20160354129A1

公开(公告)日：2016-12-08

申请号：US15171460

申请日：2016-06-02

申请人： Heraeus Medical GmbH

发明人： Sebastian VOGT ,  Thomas KLUGE

IPC分类号： A61B17/88 ,  A61L27/02 ,  A61L27/16 ,  B01F13/00 ,  B01F15/02

摘要： A device and methods mix polymethylmethacrylate bone cement and/or store the starting components of the bone cement. The device comprising: a cartridge with an internal space for mixing the bone cement that is closed on one side by means of a mobile dispensing plunger; a monomer container for a monomer liquid and/or a connector for attachment of a monomer container for a monomer liquid such that the monomer container can be opened appropriately in the device such that the monomer liquid flows from the monomer container into the device; a connecting conduit through which the monomer liquid can be guided into the internal space of the cartridge. A first hollow cylinder is connected to the connecting conduit and a second hollow cylinder is connected, via a vacuum conduit, to the internal space of the cartridge, whereby a pumping plunger is shiftable axially in the first hollow cylinder and is arranged in the first hollow cylinder and a vacuum plunger that is shiftable axially in the second hollow cylinder is arranged in the second hollow cylinder, whereby the pumping plunger and the vacuum plunger may be moved simultaneously.

摘要翻译： 一种装置和方法混合聚甲基丙烯酸甲酯骨水泥和/或储存骨水泥的起始组分。 所述装置包括：具有内部空间的药筒，所述内部空间用于混合通过移动分配柱塞在一侧封闭的骨粘固剂; 用于单体液体的单体容器和/或用于连接单体液体的单体容器的连接器，使得单体容器可以在装置中适当地打开，使得单体液体从单体容器流入装置; 连接导管，单体液体可以通过该导管引导到盒的内部空间中。 第一中空圆筒连接到连接导管，第二中空圆筒经由真空导管连接到墨盒的内部空间，由此泵送柱塞在第一中空圆柱体中轴向移动并且布置在第一空心圆筒 气缸和在第二中空圆柱体中可轴向移动的真空柱塞布置在第二中空圆柱体中，由此泵送柱塞和真空柱塞可以同时移动。