公开(公告)号：US20120183632A1

公开(公告)日：2012-07-19

申请号：US13427334

申请日：2012-03-22

Applicant: Hyeong Kyu LEE ,  Sei Ryang OH ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

Inventor： Hyeong Kyu LEE ,  Sei Ryang OH ,  Kyung Seop AHN ,  Sang Ku LEE ,  Joong Ku LEE ,  Ok Kyoung KWON ,  Doo Young KIM ,  Hyouk JOUNG ,  Gui Hua QUAN ,  Mi Jin KIM ,  Bo Young PARK

IPC: A61K36/68 ,  A61P29/00 ,  A61P37/08 ,  A61K31/7048

CPC classification number: A61K36/185 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/352 ,  A61K36/68 ,  A61K36/80 ,  C07H17/04 ,  A23V2250/21 ,  A23V2200/324 ,  A23V2200/304

Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。

公开(公告)号：US20100081638A1

公开(公告)日：2010-04-01

申请号：US12626553

申请日：2009-11-25

Applicant: Hyeong-Kyu Lee ,  Sei-Ryang Oh ,  Kyungseop Ahn ,  Joongku Lee ,  Sangku Lee ,  Ho-Jae Lee ,  Doo-Young Kim ,  Jung-Hee Kim ,  Eun-Ah Kim ,  Soon-Ja Choi ,  Soo Hyun Kim ,  Jung Weon Lee ,  Su-Yong Choi

Inventor： Hyeong-Kyu Lee ,  Sei-Ryang Oh ,  Kyungseop Ahn ,  Joongku Lee ,  Sangku Lee ,  Ho-Jae Lee ,  Doo-Young Kim ,  Jung-Hee Kim ,  Eun-Ah Kim ,  Soon-Ja Choi ,  Soo Hyun Kim ,  Jung Weon Lee ,  Su-Yong Choi

IPC: A61K31/56 ,  C07J53/00

CPC classification number: A61K36/185 ,  A23L33/105

Abstract: The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.

Abstract translation: 本发明涉及一种脱氧诱导剂，其包含与其分离的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐，其对表达肿瘤相关抗原L6的癌细胞或其同源物是特异性的。 本发明的天竺葵多酚提取物，从其分离的噻托溴酸化合物或其药学上可接受的盐导致细胞粘附丧失，以减少癌细胞增殖，并表现出在表达肿瘤相关抗原L6的癌细胞中诱导细胞死亡的作用 其同系物，因此用于预防和治疗由于肿瘤相关抗原L6或其同源物引起的癌症。

公开(公告)号：US20090148542A1

公开(公告)日：2009-06-11

申请号：US11989053

申请日：2006-07-18

Applicant: Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Joong Ku Lee ,  Sang Ku Lee ,  Jung Hee Kim ,  Doo Young Kim ,  Gui Hua Quan ,  Ok Kyoung Kwon ,  Eun Ah Kim ,  Soon Ja Choi ,  Guang Hai Shen ,  Mi Jin Kim ,  Bo Young Park ,  Byung Sun Min ,  Gyoon Hee Han ,  Hea Young Park ,  Gun Cheol Kim ,  Joo Heon Kim ,  So Young Kim

Inventor： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Joong Ku Lee ,  Sang Ku Lee ,  Jung Hee Kim ,  Doo Young Kim ,  Gui Hua Quan ,  Ok Kyoung Kwon ,  Eun Ah Kim ,  Soon Ja Choi ,  Guang Hai Shen ,  Mi Jin Kim ,  Bo Young Park ,  Byung Sun Min ,  Gyoon Hee Han ,  Hea Young Park ,  Gun Cheol Kim ,  Joo Heon Kim ,  So Young Kim

IPC: A61K36/00 ,  C07J53/00 ,  A61P29/00 ,  A61P37/08 ,  A61P11/06

CPC classification number: C07J53/00 ,  A23L33/105 ,  A61K36/185 ,  Y10S514/826

Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。

公开(公告)号：US20080113005A1

公开(公告)日：2008-05-15

申请号：US11813285

申请日：2006-01-04

Applicant: Jong Won Lee ,  Ki-Chul Hwang ,  Hyung Soo Han ,  Sun Ha Lim ,  Hyeong-Kyu Lee ,  Sang Hyuk Lee ,  Kyu Won Kim ,  Hyung Oh Jun ,  Hyun Jeong Kim ,  In-Seon Lee ,  Chae Ha Yang

Inventor： Jong Won Lee ,  Ki-Chul Hwang ,  Hyung Soo Han ,  Sun Ha Lim ,  Hyeong-Kyu Lee ,  Sang Hyuk Lee ,  Kyu Won Kim ,  Hyung Oh Jun ,  Hyun Jeong Kim ,  In-Seon Lee ,  Chae Ha Yang

IPC: A61K36/899 ,  A61K9/00 ,  A61P25/28

CPC classification number: A61K36/899 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/21

Abstract: The present invention relates to a composition comprising extracts of Gramineae plant that improves cell viability under hypoxic conditions by inhibiting apoptosis. Thus, the extract of Triticum aestivum L., one of the Gramineae plant, of the present invention, in particular, prevents damage of brain, heart and kidney in animal models of ischemic diseases, and it also improves memory in an animal model of Alzheimer's disease. Therefore, a composition comprising extracts of Gramineae can be used as therapeutic agents or health care foods for preventing and treating ischemic diseases and degenerative brain diseases.

Abstract translation: 本发明涉及包含通过抑制细胞凋亡在缺氧条件下改善细胞活力的禾本科植物提取物的组合物。 因此，特别地，本发明的禾本科植物之一的小麦Triticum aestivum L.的提取物防止脑，心脏和肾脏在缺血性疾病的动物模型中的损伤，并且还改善了阿尔茨海默病动物模型中的记忆 疾病。 因此，包含禾本科植物提取物的组合物可用作预防和治疗缺血性疾病和退行性脑疾病的治疗剂或保健食品。

公开(公告)号：US20070066577A1

公开(公告)日：2007-03-22

申请号：US11549280

申请日：2006-10-13

Applicant: Hea Young Park Choo ,  Hyeong-Kyu Lee ,  Sei-Ryang Oh ,  Kyungseop Ahn ,  Gyoonhee Han ,  Joo Heon Kim

Inventor： Hea Young Park Choo ,  Hyeong-Kyu Lee ,  Sei-Ryang Oh ,  Kyungseop Ahn ,  Gyoonhee Han ,  Joo Heon Kim

IPC: A61K31/4745 ,  A61K31/655 ,  A61K31/428 ,  A61K31/423 ,  C07D498/02 ,  C07D491/02

CPC classification number: A61K31/423 ,  A61K31/428 ,  A61K31/4745 ,  C07D263/58 ,  C07D277/64 ,  C07D277/66 ,  C07D417/04 ,  C07D513/04

Abstract: A novel benzoxazole derivative of formula (I) or a pharmaceutically acceptable salt thereof is effective for inhibiting 5-lipoxygenase which is useful for preventing or treating leukotriene-related diseases. The prevention also provides a pharmaceutical composition containing same and a method for preventing or treating leukotriene-related diseases.

Abstract translation: 式（I）的新型苯并恶唑衍生物或其药学上可接受的盐可有效抑制用于预防或治疗白三烯相关疾病的5-脂氧合酶。 该预防还提供含有其的药物组合物和预防或治疗白三烯相关疾病的方法。

公开(公告)号：US5114873A

公开(公告)日：1992-05-19

申请号：US592807

申请日：1990-10-04

Applicant: Kyung-hun Kim ,  Seong-tae Kim ,  Hyeong-kyu Lee

Inventor： Kyung-hun Kim ,  Seong-tae Kim ,  Hyeong-kyu Lee

IPC: H01L21/8242

CPC classification number: H01L27/10852

Abstract: The method comprises the steps of: forming the transistor on a substrate and then depositing an interlayer insulating layer, and forming a design pattern of a first conductive layer by vertically etching it using a mask; horizontally overetching the pattern by using the etching process used for forming the pattern; depositing a first insulating film and then depositing the second conductive layer to the thickness needed to protect the first insulating film; vertically etching the second conductive layer, first insulating film and interlayer insulating layer by applying the mask used in vertically etching the first conductive layer; additionally depositing the second conductive layer; forming a design pattern of the second conductive layer by vertically etching it using a mask; horizontally overetching the pattern of the second conductive layer; depositing the second insulating film and then depositing a third conductive layer to have the thickness to protect the second insulating film; vertically etching the third conductive layer and second insulating film by applying the etching mask of the second conductive layer; additionally depositing the third conductive layer. The method attains larger effective capacitance in which a plate electrode layer surrounds even the lower surface of a storage electrode layer of the stack capacitor without using any extra mask.

Abstract translation: 该方法包括以下步骤：在衬底上形成晶体管，然后沉积层间绝缘层，并通过使用掩模垂直蚀刻形成第一导电层的设计图案; 通过使用用于形成图案的蚀刻工艺水平地过蚀刻图案; 沉积第一绝缘膜，然后将第二导电层沉积到保护第一绝缘膜所需的厚度; 通过施加用于垂直蚀刻第一导电层的掩模来垂直蚀刻第二导电层，第一绝缘膜和层间绝缘层; 另外沉积第二导电层; 通过使用掩模垂直蚀刻来形成第二导电层的设计图案; 水平地蚀刻第二导电层的图案; 沉积第二绝缘膜，然后沉积第三导电层以具有保护第二绝缘膜的厚度; 通过施加第二导电层的蚀刻掩模来垂直蚀刻第三导电层和第二绝缘膜; 另外沉积第三导电层。 该方法获得更大的有效电容，其中平板电极层甚至包围堆叠电容器的存储电极层的下表面，而不使用任何额外的掩模。