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8 条记录 (耗时 0.016 秒)

    STROKE-TAGETING PEPTIDE AND USE THEREOF
    1.
    发明申请
    STROKE-TAGETING PEPTIDE AND USE THEREOF 失效
    抗菌肽及其用途

    公开(公告)号：US20110150764A1

    公开(公告)日：2011-06-23

    申请号：US12995934

    申请日：2009-06-02

    申请人： Byung-Heon Lee ,  In San Kim ,  Hyung Soo Han ,  Jeong Soo Yoo

    发明人： Byung-Heon Lee ,  In San Kim ,  Hyung Soo Han ,  Jeong Soo Yoo

    IPC分类号： A61K51/08 ,  C07K7/06 ,  C07H21/00 ,  C12N9/00 ,  C07C229/08 ,  A61K49/00 ,  A61K38/08 ,  A61K38/43 ,  A61P9/10

    CPC分类号： C07K7/06

    摘要： The present invention relates to stroke-targeting peptides and use thereof. More specifically, the present invention relates to a stroke-targeting peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 4 and use thereof. The peptide of the present invention can be specifically bound to stroke cells in the subject, and thus can be effectively used in diagnostic markers and kits for stroke, and compositions for drug delivery specific to stroke and pharmaceutical compositions and compositions for imaging stroke.

    摘要翻译： 本发明涉及中风靶向肽及其用途。 更具体地，本发明涉及包含选自SEQ ID NO：1至SEQ ID NO：4的氨基酸序列的中风靶向肽及其用途。 本发明的肽可以特异性地结合到受试者的中风细胞中，因此可以有效地用于中风诊断标记物和试剂盒，以及用于中风特异性药物递送的组合物和用于成像中风的药物组合物和组合物。

    Stroke-targeting peptide and use thereof
    2.
    发明授权
    Stroke-targeting peptide and use thereof 失效
    中风靶向肽及其用途

    公开(公告)号：US08748398B2

    公开(公告)日：2014-06-10

    申请号：US12995934

    申请日：2009-06-02

    申请人： Byung-Heon Lee ,  In S. Kim ,  Hyung Soo Han ,  Jeong Soo Yoo

    发明人： Byung-Heon Lee ,  In S. Kim ,  Hyung Soo Han ,  Jeong Soo Yoo

    IPC分类号： A61K38/08 ,  C07K7/06 ,  C12N15/00

    CPC分类号： C07K7/06

    摘要： The present invention relates to stroke-targeting peptides and use thereof. More specifically, the present invention relates to a stroke-targeting peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 4 and use thereof. The peptide of the present invention can be specifically bound to stroke cells in the subject, and thus can be effectively used in diagnostic markers and kits for stroke, and compositions for drug delivery specific to stroke and pharmaceutical compositions and compositions for imaging stroke.

    摘要翻译： 本发明涉及中风靶向肽及其用途。 更具体地，本发明涉及包含选自SEQ ID NO：1至SEQ ID NO：4的氨基酸序列及其用途的中风靶向肽。 本发明的肽可以特异性地结合到受试者的中风细胞中，因此可以有效地用于中风诊断标记物和试剂盒，以及用于中风特异性药物递送的组合物和用于成像中风的药物组合物和组合物。

    Composition comprising starch or dietary fiber from gramineae plant for prevention and treatment of ischemic diseases and degenerative brain disease
    3.
    发明授权
    Composition comprising starch or dietary fiber from gramineae plant for prevention and treatment of ischemic diseases and degenerative brain disease 有权
    组合物，其包含来自禾本科植物的淀粉或膳食纤维，用于预防和治疗缺血性疾病和退行性脑病

    公开(公告)号：US08211483B2

    公开(公告)日：2012-07-03

    申请号：US12666969

    申请日：2008-07-04

    申请人： Jong Won Lee ,  Yae Sil Kim ,  Kyung Sik Song ,  Hyung Soo Han ,  Jung Hee Jang ,  Chae Ha Yang ,  Sun Ha Lim

    发明人： Jong Won Lee ,  Yae Sil Kim ,  Kyung Sik Song ,  Hyung Soo Han ,  Jung Hee Jang ,  Chae Ha Yang ,  Sun Ha Lim

    IPC分类号： A61K36/00 ,  A61K36/899 ,  A61K31/715

    CPC分类号： A61K31/715 ,  A61K31/718

    摘要： The present invention relates to a composition comprising a starch or total dietary fiber which improves the cell viability, specifically, the inventive starch and total dietary fiber isolated from the extract of Gramineae plant and the components therefrom improved the cell viability when the cells were incubated under hypoxic condition, or in the presence of beta-amyloid and 6-hydroxydopamine treatment, as well as prevented and treated myocardiac infarction, cerebral infarction and vascular dementia, or alleviated memory loss, all of which were proven using rats as the respective animal models. Therefore, they can be used as therapeutics or health care food for preventing and treating ischemic diseases or degenerative brain diseases.

    摘要翻译： 本发明涉及一种组合物，其包含改善细胞存活力的淀粉或总膳食纤维，具体地，本发明的淀粉和从禾本科植物提取物中分离的总膳食纤维，并且其组分在细胞孵育时改善了细胞活力 或在β-淀粉样蛋白和6-羟基多巴胺治疗的存在下，以及预防和治疗的心肌梗死，脑梗死和血管性痴呆，或缓解记忆丧失，所有这些都使用大鼠作为相应的动物模型。 因此，它们可以用作预防和治疗缺血性疾病或退行性脑疾病的治疗剂或保健食品。

    PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF
    7.
    发明申请
    PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF 有权
    通过血脑屏障通过的肽和靶向神经损伤性脑病的病原体及其用途

    公开(公告)号：US20120288447A1

    公开(公告)日：2012-11-15

    申请号：US13469729

    申请日：2012-05-11

    申请人： Byung-Heon Lee ,  In San Kim ,  Jae-Sung Bae ,  Hee Kyoung Jin ,  Hyung Soo Han

    发明人： Byung-Heon Lee ,  In San Kim ,  Jae-Sung Bae ,  Hee Kyoung Jin ,  Hyung Soo Han

    IPC分类号： A61K49/00 ,  C12N9/96 ,  A61K38/08 ,  A61P25/16 ,  A61P25/00 ,  C07K7/06 ,  A61P25/28

    CPC分类号： A61K49/0002 ,  A61K38/00 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0056 ,  B82Y5/00 ,  C07K7/06

    摘要： The present invention relates to a peptide that passes through a blood-brain barrier and targets apoptosis of neurodegenerative brain disease-affected sites and uses thereof. More particularly, the present invention relates to a composition for delivering drugs to brain tissues, a composition for detecting apoptotic cells of neurodegenerative brain disease-affected sites, and a composition for imaging the neurodegenerative brain disease-affected sites which comprises a peptide having an amino acid sequence represented by SEQ ID: No. 1 respectively, and a composition for prevention, treatment, or theranosis of neurodegenerative brain diseases comprising said peptide. The peptide of the present invention can be used for detecting apoptosis in neurodegenerative brain diseases and further detecting apoptotic cells (especially apoptotic neuronal cells) in neurodegenerative brain disease-affected sites and imaging, targeted drug delivery, theranosis.

    摘要翻译： 本发明涉及穿过血脑屏障并靶向神经退行性脑损伤部位的细胞凋亡的肽及其用途。 更具体地，本发明涉及用于将药物递送至脑组织的组合物，用于检测神经变性脑病变部位的凋亡细胞的组合物，以及用于对神经变性性脑病变影响部位进行成像的组合物，所述组合物包含具有氨基 分别由SEQ ID：No.1表示的酸序列，以及包含所述肽的神经变性性脑病的预防，治疗或异常的组合物。 本发明的肽可用于检测神经变性脑疾病的凋亡，并进一步检测神经变性脑疾病影响部位的凋亡细胞（特别是凋亡性神经元细胞），成像，靶向药物递送，神经病变。