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公开(公告)号:US06245889B1
公开(公告)日:2001-06-12
申请号:US08925779
申请日:1997-09-09
IPC分类号: C07K1451
CPC分类号: A61L27/227 , A61K38/00 , A61L24/043 , C07K14/51 , Y10S514/801 , Y10S514/90 , Y10S930/12 , C08L89/00
摘要: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2和BMP-4蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US6034061A
公开(公告)日:2000-03-07
申请号:US750222
申请日:1996-12-04
IPC分类号: C12N15/09 , A61K9/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61K38/30 , A61L27/22 , A61P1/02 , A61P1/16 , A61P19/02 , A61P43/00 , C07K14/51 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号: C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12
摘要: Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
摘要翻译: 公开了纯化骨形态发生蛋白(BMP)-9蛋白及其制备方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复以及肝脏生长和功能。
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公开(公告)号:US5939388A
公开(公告)日:1999-08-17
申请号:US788729
申请日:1997-01-23
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , C12N2800/108 , C12N2840/20
摘要: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-5蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5932216A
公开(公告)日:1999-08-03
申请号:US926885
申请日:1997-09-10
申请人: Anthony J. Celeste , John M. Wozney
发明人: Anthony J. Celeste , John M. Wozney
CPC分类号: C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要: Purified Bone Morphogenetic Protein-10(BMP-10) proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化骨形态发生蛋白-10(BMP-10)蛋白及其制备方法。 还公开了编码BMP-10蛋白质的DNA分子。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5637480A
公开(公告)日:1997-06-10
申请号:US247908
申请日:1994-05-20
申请人: Anthony J. Celeste , John M. Wozney
发明人: Anthony J. Celeste , John M. Wozney
CPC分类号: C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要: Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化骨形态发生蛋白-10蛋白及其制备方法。 还公开了编码BMP-10蛋白的重组DNA分子。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5631142A
公开(公告)日:1997-05-20
申请号:US118363
申请日:1993-09-07
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2蛋白质及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US4877864A
公开(公告)日:1989-10-31
申请号:US31346
申请日:1987-03-26
申请人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
发明人: Elizabeth A. Wang , John M. Wozney , Vicki Rosen
CPC分类号: C07K14/51 , A61K35/32 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Human and bovine bone inductive factors are provided. Such factors may be produced by recombinant techniques and be useful in the treatment of bone defects.
摘要翻译: 提供了人骨和牛骨诱导因子。 这些因素可以通过重组技术产生并且可用于治疗骨缺损。
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公开(公告)号:US07091007B2
公开(公告)日:2006-08-15
申请号:US10600645
申请日:2003-06-23
摘要: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译: 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质,以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。
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公开(公告)号:US6027919A
公开(公告)日:2000-02-22
申请号:US333576
申请日:1994-11-02
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号: C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号: A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要: The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译: 本发明涉及一种纯化蛋白质的新家族,以及含有这些蛋白质的组合物,该组合物可用于诱导腱/类韧带组织形成,伤口愈合和韧带以及其它组织修复。 本发明还涉及可用于生产这种蛋白质的DNA分子,载体和宿主细胞。
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公开(公告)号:US5661007A
公开(公告)日:1997-08-26
申请号:US50132
申请日:1993-04-22
申请人: John M. Wozney , Anthony J. Celeste
发明人: John M. Wozney , Anthony J. Celeste
IPC分类号: A61K38/00 , A61K47/02 , A61K47/34 , A61K47/42 , A61L27/00 , A61P1/02 , A61P17/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , A61K38/18 , C12N15/79
CPC分类号: C07K14/51 , A61K38/00 , C07K2319/02
摘要: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed, The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: PCT No.PCT / US92 / 05374 Sec。 371日期:1993年4月22日 102(e)日期1993年4月22日PCT提交1992年6月25日PCT公布。 公开号WO93 / 00432 日期1993年1月7日公开了纯化的骨形态发生蛋白-9(BMP-9)蛋白及其制备方法,该蛋白质可用于治疗骨和软骨缺损以及伤口愈合及相关组织修复。
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