Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    21.
    发明申请
    Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 有权
    使用组织荧光测定糖化终产物或疾病状态的测量

    公开(公告)号:US20070088205A1

    公开(公告)日:2007-04-19

    申请号:US11561380

    申请日:2006-11-17

    Abstract: A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

    Abstract translation: 确定个体中组织状态(例如,糖基化终产物或疾病状态)的量度的方法。 用激发光照射个体组织的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光,激发光的扫描(以多个波长照射组织),单个波长的检测,检测波长的扫描(检测多个波长的发射光)及其组合。 本发明还可以包括校正技术,其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如,如果不采用适当的校正,组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型,包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用,有助于测定组织状态。 本发明还包括适于执行该方法的装置,包括用于检测荧光和组织状态测量的适当的光源,检测器和模型(例如,在计算机上实现)。

    Method and Apparatus to Compensate for Melanin and Hemoglobin Variation in Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    24.
    发明申请
    Method and Apparatus to Compensate for Melanin and Hemoglobin Variation in Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 失效
    用于补偿黑色素和血红蛋白变化的方法和装置,用于测定糖化终产物或疾病状态的测量使用组织荧光

    公开(公告)号:US20080103373A1

    公开(公告)日:2008-05-01

    申请号:US11964665

    申请日:2007-12-26

    Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual is disclosed. A portion of the skin of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can illuminate the skin and detect responsive light over a time that spans a plurality of cardiac cycles of the individual, which can, as an example, help mitigate the effects of time-varying signals such as those due to hemoglobin. The invention can also determine the amount of light to be directed to the skin, for example by controlling the time that a light source is energized. The amount of illumination light can be determined from a skin reflectance characteristic such as pigmentation or melanin in the skin. Controlling the amount of light directed to the tissue can reduce the dynamic range required of a corresponding optical system, for example by allowing a single system to accurately measure individuals with very light skin and individuals with very dark skin.

    Abstract translation: 公开了确定个体中组织状态(例如糖基化终产物或疾病状态)的测量方法。 用激发光照射个体皮肤的一部分,然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以照亮皮肤并且在跨越个体的多个心脏周期的时间内检测响应光,其可以作为示例有助于减轻诸如由于血红蛋白引起的时变信号的影响。 本发明还可以例如通过控制光源被激励的时间来确定要引导到皮肤的光量。 照明光的量可以根据皮肤的皮肤反射特性如皮肤中的色素沉着或黑色素来确定。 控制指向组织的光量可以减少相应光学系统所需的动态范围,例如通过允许单个系统准确地测量具有非常浅的皮肤的个体和具有非常暗的皮肤的个体。

    Thermal control through a channel structure
    25.
    发明申请
    Thermal control through a channel structure 有权
    通过通道结构进行热控制

    公开(公告)号:US20080049388A1

    公开(公告)日:2008-02-28

    申请号:US11413853

    申请日:2006-04-27

    CPC classification number: G11B33/124 G06F1/20 G11B33/128 G11B33/1426

    Abstract: Thermal control through a channel structure is disclosed. In one embodiment, an apparatus includes devices operable at an undesired temperature relative to a desired operating temperature, a vented cover of each of devices, and a channel structure formed along a side face of each of the devices, the channel structure having any number of ridges to transfer a gas between the vented cover and an external location to the apparatus. The gas may modify an operating state of the devices from the undesired temperature to the desired operating temperature. A heat structure coupled to the vented cover and the side face may absorb a portion of an energy dissipated by at least one of the devices. A printed circuit board may be formed along an opposite face relative to the vented cover to enable the gas to escape to the external location through a cavity of the apparatus.

    Abstract translation: 公开了通过通道结构的热控制。 在一个实施例中,一种装置包括可在相对于期望的操作温度的不期望的温度下操作的装置,每个装置的通风盖以及沿着每个装置的侧面形成的通道结构,所述通道结构具有任何数量的 将通气盖和外部位置之间的气体传送到设备的脊。 气体可以将装置的操作状态从不期望的温度改变到期望的操作温度。 耦合到通风盖和侧面的热结构可以吸收由至少一个装置消散的能量的一部分。 印刷电路板可以沿着相对于通风盖的相对面形成,以使得气体能够通过设备的空腔逸出到外部位置。

    Handicap-accessible bath facility
    27.
    发明授权
    Handicap-accessible bath facility 失效
    残疾人无障碍浴室

    公开(公告)号:US4899402A

    公开(公告)日:1990-02-13

    申请号:US251160

    申请日:1988-09-29

    CPC classification number: A47K17/028 A47K1/04 A47K3/28

    Abstract: A handicap-accessible bath facility (10), and a method of making the same, involves a two piece modular wall (22) having a height and a length which are less than the height and length of an existing room (16) in which the bath facility is to be mounted. The modular wall comprises top and bottom wall assemblies (42, 44) which are placed parallel to a first existing wall (14) and abutting a second existing wall (16) to form a shower compartment (124). A factory molded shower base (24) is placed on an existing floor (21) in the shower compartment and defines a shower-base ramp (94) at an entrance to the compartment. A barrier line (98) at the top of the ramp, between the ramp and a drain depression (90) formed in the shower base prevents water from flowing out of the shower compartment. Wall panels (26, 28, 30) line the shower compartment and engage a vertical lip (100) of the shower base for preventing water from leaving the shower compartment at intersections of these panels with the shower base. A vanity top (32), with right angled edges (106, 108) forms a brace between the modular wall and the second existing wall. A commode (36), sink (34), and light (40) are mounted on an outside surface of the modular wall.

    Abstract translation: 残疾人无障碍浴室(10)及其制造方法涉及两件式的模块化壁(22),其高度和长度小于现有房间(16)的高度和长度,其中 洗澡设施将被安装。 所述模块化壁包括顶壁和底壁组件(42,44),其平行于第一现有壁(14)放置并邻接第二现有壁(16)以形成淋浴室(124)。 工厂模制的淋浴器底座(24)被放置在淋浴室的现有地板(21)上,并且在隔室的入口处限定了淋浴器基座斜坡(94)。 在斜坡顶部的斜坡和形成在淋浴器底座之间的排水口(90)之间的隔离线(98)防止水从淋浴室流出。 壁板(26,28,30)排列淋浴室并与淋浴底座的垂直唇缘(100)接合,以防止水在这些面板与淋浴器底座的交叉处离开淋浴室。 具有直角边缘(106,108)的梳妆台(32)在模块化壁和第二现有壁之间形成支柱。 在模块化墙体的外表面上安装有一个(36),水槽(34)和灯(40)。

    Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
    28.
    发明申请
    Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 审中-公开
    用于使用组织荧光测定糖化终产物或疾病状态的方法和装置

    公开(公告)号:US20110313296A9

    公开(公告)日:2011-12-22

    申请号:US11964675

    申请日:2007-12-26

    Abstract: Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.

    Abstract translation: 本发明的实施方案提供了适合于从组织收集的光谱信息确定体内组织的性质的装置。 照明系统提供多个宽带范围的光,其传送到光学探针。 光学探头接收来自照明系统的光,并将其透射到体内组织,并响应于宽带光或其组合,接收通过其体内组织发射的宽带光而漫射反射的光。 光学探针将光传送到产生表示光的光谱性质的信号的光谱仪。 分析系统根据光谱性质确定体内组织的性质。 校准装置安装成使其周期性地与光学探针光通信。

    Three Axis Aerodynamic Control of Guided Munitions
    29.
    发明申请
    Three Axis Aerodynamic Control of Guided Munitions 审中-公开
    导弹弹道三轴气动控制

    公开(公告)号:US20080029641A1

    公开(公告)日:2008-02-07

    申请号:US11629921

    申请日:2006-02-07

    CPC classification number: F42B10/64

    Abstract: An apparatus for 3-axis aerodynamic control of multi-caliber bodies comprising three shafts each having at least one canard; bevel gears attached to said shafts; and a set of three miniature stepper motors, each driving a zero backlash spur assembly attached to the drive bevel gears.

    Abstract translation: 一种用于多口径机体的三轴空气动力学控制的装置,包括三个轴,每个轴具有至少一个胡须; 附接到所述轴的锥齿轮; 和一组三个微型步进电机,每个驱动一个零齿轮间隙组件,附着在驱动锥齿轮上。

    Ballistic Guidance Control for Munitions
    30.
    发明申请
    Ballistic Guidance Control for Munitions 有权
    弹道导弹控制弹药

    公开(公告)号:US20070241227A1

    公开(公告)日:2007-10-18

    申请号:US11629060

    申请日:2006-02-07

    Abstract: A method and system for guiding and controlling an ordinance body having a trajectory and a bore sight angle including making corrections to the trajectory based on bore sight angle vs. time history. The system is incorporated with existing fuse components in a replacement kit for existing munitions. The method determines nominal time values of the ballistic trajectory of the munition in relation to launch time and determines deviation from the nominal time values by an algorithm by analyzing signals received from a source of radiation located at the target. A processor determines lateral (left/right) and range errors and provides steering commands to a plurality of flight control surfaces mounted on the munition.

    Abstract translation: 用于引导和控制具有轨迹和钻孔视角的条例体的方法和系统,包括基于钻孔视角对时间历史对轨迹进行校正。 该系统与现有的弹药更换套件中的现有保险丝组件相结合。 该方法确定弹药弹道轨迹与发射时间的标称时间值,并通过分析从位于目标位置的辐射源接收的信号,确定通过算法与标称时间值的偏差。 处理器确定侧向(左/右)和范围误差,并向安装在弹药上的多个飞行控制表面提供转向命令。

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