公开(公告)号：US20190099465A1

公开(公告)日：2019-04-04

申请号：US16086672

申请日：2017-04-07

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Ohn Soon KIM ,  Yun Mi LEE ,  Young-Sil LEE ,  Eun Jung SON

IPC: A61K36/9062 ,  A61K45/06 ,  A61P19/06 ,  A23L33/105

CPC classification number: A61K36/9062 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/21 ,  A61K45/06 ,  A61K2236/331 ,  A61P19/06

Abstract: The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of Alpinia oxyphylla as an effective ingredient. Because the extract of Alpinia oxyphylla of the present invention can reduce the uric acid amount in blood of an animal model and is derived from natural products, and the raw materials can be easily obtained, it can be widely used in industries that are related to hyperuricemia or metabolic disorders related with hyperuricemia. It can be effectively used for prevention, amelioration, or treatment of gout or gouty arthritis, in particular.

公开(公告)号：US20180271923A1

公开(公告)日：2018-09-27

申请号：US15974324

申请日：2016-05-31

Applicant: Korea Institute of Oriental Medicine

Inventor： Byoung Seob Ko ,  Sun Min Park ,  Hye Won Lee ,  Jin Ah Ryuk ,  In Sil Park ,  Su Ran Kim

IPC: A61K36/185 ,  A23L33/105

CPC classification number: A61K36/185 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/00

Abstract: The present invention relates to: a pharmaceutical composition for preventing or treating menopausal disorders, containing a Tetragonia tetragonoides (Pall.) Kuntze extract or a fraction thereof; a method for preventing or treating menopausal disorders, comprising a step of administering the pharmaceutical composition; and a food composition containing the extract or a fraction thereof. The Tetragonia tetragonoides (Pall.) Kuntze extract of the present invention shows effects of alleviating obesity, which is representative of glucose metabolism disorders and lipid metabolism disorders, osteoporosis, which is representative of bone homeostasis disorders, and flushing, which is representative of energy metabolism disorders, and thus the extract can be used in food, a medicine and the like so as to prevent, alleviate or treat menopausal disorders.

公开(公告)号：US09839594B2

公开(公告)日：2017-12-12

申请号：US14651876

申请日：2013-10-18

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Sung Uk Chae ,  Mi Young Lee

IPC: A61K8/63 ,  A61Q19/00 ,  A61Q19/08 ,  A61K31/7048 ,  A61K36/8964 ,  A61K8/60 ,  A61K8/97 ,  A61K31/7028 ,  A61K31/704

CPC classification number: A61K8/63 ,  A61K8/60 ,  A61K8/97 ,  A61K31/7028 ,  A61K31/704 ,  A61K31/7048 ,  A61K36/8964 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present invention relates to a skin-moisturizing or wrinkle-improving external composition or cosmetic composition which contains, as an active ingredient, a compound represented by Formula 1, which can be extracted from Anemarrhena asphodeloides Bunge, or a pharmaceutically acceptable salt thereof. The composition prevents skin moisture loss and thus suppresses skin tissue damage induced by UV rays and so has a skin-wrinkle preventing or alleviating effect.

公开(公告)号：US20170182107A1

公开(公告)日：2017-06-29

申请号：US15313341

申请日：2015-05-21

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook KIM ,  Junghyun KIM ,  Chan-Sik KIM ,  Eunjin SHON ,  Yun Mi LEE ,  Sojin CHOI ,  Ik Soo LEE ,  Young Sook KIM ,  Dong Ho JUNG ,  Bo-Jeong PYUN ,  Seung-Hyun JUNG

IPC: A61K36/65 ,  A61K36/54

CPC classification number: A61K36/65 ,  A61K36/54

Abstract: The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy. and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.

公开(公告)号：US09433655B2

公开(公告)日：2016-09-06

申请号：US14441172

申请日：2013-11-06

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Hyun Kyoo Shin ,  Ju Young Jung ,  Hye Kyung Ha ,  Chang Seob Seo ,  Young Jung Kim

IPC: A61K36/00 ,  A61K36/53

CPC classification number: A61K36/53

Abstract: Disclosed is a composition including an Elsholtziae Herba extract as an active ingredient, which can be used for the prevention, improvement, or treatment of acute renal failure.

Abstract translation: 公开了一种组合物，其包含作为活性成分的榆树提取物，其可用于预防，改善或治疗急性肾功能衰竭。

公开(公告)号：US20150088014A1

公开(公告)日：2015-03-26

申请号：US14399930

申请日：2013-05-08

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Young Ju Jeon ,  Jae Uk Kim ,  Jang Han Bae ,  Young Min Kim ,  Jong Yeol Kim ,  Si Woo Lee

IPC: A61B5/024

CPC classification number: A61B5/02444 ,  A61B5/02108

Abstract: The present invention relates to a pulse depth index extraction device and method using pressure at a constant velocity. A device comprises: a pressure applying unit for applying a pressure at a constant velocity to a confirmed pulse location in a direction perpendicular to the skin; a pressure pulse wave signal measuring unit for measuring a pressure pulse wave signal generated based on the applied pressure; and a measured signal analysis unit for deriving the pulse depth index (PDI) by using the measured pressure pulse wave signal.

Abstract translation: 本发明涉及脉冲深度指数提取装置和以恒定速度使用压力的方法。 一种装置包括：压力施加单元，用于以与所述皮肤垂直的方向上的确定的脉冲位置以恒定的速度施加压力; 用于测量基于所施加的压力产生的压力脉搏波信号的压力脉搏波信号测量单元; 以及测量信号分析单元，用于通过使用所测量的压力脉搏波信号来导出脉冲深度指数（PDI）。

公开(公告)号：US20250121020A1

公开(公告)日：2025-04-17

申请号：US18989473

申请日：2024-12-20

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： MALK EUN PAK ,  YOUNGHOON GO ,  WEI LI ,  HYE JIN YANG

IPC: A61K36/752 ,  A23K20/10 ,  A61K36/076 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/725 ,  A61K36/8888 ,  A61K36/9068 ,  A61P25/28

Abstract: A composition including Yukgunjatang as effective component is effective for improving memory and preventing, alleviating, or treating cognitive disorder. Yukgunjatang, which is prepared by boiling a mixture of Gingseng Radix, Atractylodes rhizoma alba, Hoelen, Glycyrrhizae Radix, Aurantii Nobilis Pericarpium, Pinelliae Rhizoma, Zingiberis Rhizoma, and Zizyphi Fructus in water, exhibits superior neuroprotective effect compared to individual extracts of Gingseng Radix, Atractylodes rhizoma alba, Hoelen, Glycyrrhizae Radix, Aurantii Nobilis Pericarpium, Pinelliae Rhizoma, Zingiberis Rhizoma, and Zizyphi Fructus, and, in an animal model of cognitive decline induced by scopolamine, administration of Yukgunjatang shows the effect of improving memory and cognitive function. Thus, the composition can be advantageously used as a food product, a medicinal product, or the like for preventing or treating brain diseases including Alzheimer's disease, Parkinson's disease, and mild cognitive impairment.

公开(公告)号：US11944460B2

公开(公告)日：2024-04-02

申请号：US16757101

申请日：2018-09-18

Applicant: Korea Institute of Oriental Medicine

Inventor： Jang Han Bae ,  Young Ju Jeon ,  Jong Yeol Kim

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/024

CPC classification number: A61B5/7221 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/4854 ,  A61B5/7235

Abstract: A method for determining a sharpness index of a pulse wave signal includes receiving a pulse wave signal; determining a first reference line starting point and a second reference line starting point on the basis of a curvature of the pulse wave signal; determining a first reference line connecting the first reference line starting point and a first reference line ending point by determining the first reference line ending point by applying an intersecting tangent method to the first reference line starting point, and determining a second reference line connecting the second reference line starting point and a second reference line ending point by determining the second reference line ending point by applying the intersecting tangent method to the second reference line starting point; and determining a sharpness index by using a peak point of the pulse wave signal, the first reference line, and the second reference line.

公开(公告)号：US11541088B2

公开(公告)日：2023-01-03

申请号：US17058861

申请日：2019-05-23

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young Lee ,  Yu Ri Kim ,  Bo-Kyung Park ,  Young Hwa Kim

IPC: A61K36/185 ,  A23L33/105 ,  A61P25/20

Abstract: A method for treating a sleep disorder according to an embodiment of the present disclosure includes administering a composition comprising an extract of Hibiscus syriacus as an effective ingredient to a subject in need thereof. Because the Hibiscus syriacus extract of the present invention has an effect of improving sleep time deteriorated by stress, and an effect of reducing the content of corticosterone, which increases due to stress, and increasing the content of serotonin in blood. In addition, the composition has an effect of enhancing in a significant sense the expression of GABAR A α1 in cerebral cortex, which decreases due to stress, in a group administered with Hibiscus syriacus extract. As such, the composition comprising Hibiscus syriacus extract as an effective ingredient as an effective ingredient can be advantageously used as a functional health food composition or a pharmaceutical composition for preventing, ameliorating or treating sleeping disorders.

公开(公告)号：US20210346417A1

公开(公告)日：2021-11-11

申请号：US17284592

申请日：2019-09-26

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Mi Young LEE ,  Yu Ri KIM ,  Young Hwa KIM ,  Bo-Kyung PARK

IPC: A61K31/7048 ,  A23L33/105 ,  A23L33/125

Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes administering to a subject in need thereof a composition including saponarin of Chemical Formula 1, a salt thereof acceptable for use in food, or a hydrate thereof as an effective component: In an animal model with lack of sleep caused by caffeine, saponarin of the present invention restores the travel distance, mobility time, mobility frequency, and immobility time to normal as well as increases the mRNA expression of neuropeptide Y, cholecystokinin, and GABA A α1 receptor, thereby alleviating sleep disturbance. Therefore, the saponarin of the present invention can be advantageously used as a raw material for a functional health food or a pharmaceutical product for preventing, alleviating, or treating sleep disturbance.