公开(公告)号：US07919489B2

公开(公告)日：2011-04-05

申请号：US11894307

申请日：2007-08-20

Applicant: Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Ulrich Rosentreter ,  Martin Hendrix ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke ,  Daniela Paulsen ,  Armin Kern

Inventor： Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Ulrich Rosentreter ,  Martin Hendrix ,  Joerg Keldenich ,  Dieter Lang ,  Martin Radtke ,  Daniela Paulsen ,  Armin Kern

IPC: A61P31/12 ,  A61K31/4178 ,  A61K31/4164 ,  C07D401/12 ,  C07D233/90

CPC classification number: C07D233/90 ,  C07D401/12

Abstract: The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及杂环基酰胺取代的咪唑及其制备方法，它们用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 作为抗病毒剂，特别是针对巨细胞病毒。

公开(公告)号：US20100144752A1

公开(公告)日：2010-06-10

申请号：US11988911

申请日：2006-07-01

Applicant: Holger Zimmermann ,  David Brückner ,  Kerstin Henninger ,  Martin Hendrix ,  Martin Radtke

Inventor： Holger Zimmermann ,  David Brückner ,  Kerstin Henninger ,  Martin Hendrix ,  Martin Radtke

IPC: A61K31/497 ,  C07D401/14 ,  A61P31/22

CPC classification number: C07D409/12 ,  C07D401/12 ,  C07D417/12

Abstract: The invention relates to heterocyclylamide-substituted thiazoles, pyrroles and thiophenes and to processes for preparing them, to their use for the treatment and/or prophylaxis of diseases, and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, particularly for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及杂环基酰胺取代的噻唑，吡咯和噻吩，以及其制备方法，用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒剂，特别是抗巨细胞病毒。

公开(公告)号：US20100105673A1

公开(公告)日：2010-04-29

申请号：US12518717

申请日：2007-12-08

Applicant: Adrian Tersteegen ,  Dirk Heimbach ,  Kai Thede ,  Reinhold Welker ,  Beate Fast ,  Arnold Paessens ,  Frank Dittmer ,  Rudolf Schohe-Loop ,  Axel Harrenga ,  Alexander Hillisch ,  Kerstin Henninger ,  Walter Hübsch ,  Marcus Bauser ,  Susanne Greschat ,  Dirk Schneider ,  Tobias Marquardt ,  Andreas Göller ,  Andreas Urban ,  Steffen Wildum ,  Daniela Paulsen

Inventor： Adrian Tersteegen ,  Dirk Heimbach ,  Kai Thede ,  Reinhold Welker ,  Beate Fast ,  Arnold Paessens ,  Frank Dittmer ,  Rudolf Schohe-Loop ,  Axel Harrenga ,  Alexander Hillisch ,  Kerstin Henninger ,  Walter Hübsch ,  Marcus Bauser ,  Susanne Greschat ,  Dirk Schneider ,  Tobias Marquardt ,  Andreas Göller ,  Andreas Urban ,  Steffen Wildum ,  Daniela Paulsen

IPC: A61K31/365 ,  A61K31/5377 ,  A61K31/438 ,  C07D413/12 ,  C07D491/107 ,  C07D307/94 ,  A61P31/18 ,  A61P31/12

CPC classification number: C07D307/94 ,  C07D491/10

Abstract: The present invention relates to novel substituted aminofurans, to methods for their preparation, to their use in the treatment and/or prophylaxis of diseases as well as their use in the manufacture of medical products for the treatment and/or prophylaxis of diseases, in particular retroviral disorders, in humans and/or animals.

Abstract translation: 本发明涉及新型取代的氨基呋喃，其制备方法，其用于治疗和/或预防疾病及其在制备用于治疗和/或预防疾病的医药产品中的用途，特别是 逆转录病毒疾病，在人和/或动物中。

公开(公告)号：US20100022527A1

公开(公告)日：2010-01-28

申请号：US12392844

申请日：2009-02-25

Applicant: Dirk HEIMBACH ,  Adrian TERSTEEGEN ,  Kai THEDE ,  Reinhold WELKER ,  Beate FAST ,  Arnold PAESSENS ,  Frank DITTMER ,  Rudolph SCHOHE-LOOP ,  Axel HARRENGA ,  Alexander HILLISCH ,  Kerstin HENNINGER ,  Walter HUEBSCH ,  Marcus BAUSER ,  Daniela PAULSEN ,  Alexander BIRKMANN ,  Thomas BRETSCHNEIDER ,  Reiner FISCHER ,  Susanne GRESCHAT ,  Andreas URBAN ,  Steffen WILDUM

Inventor： Dirk HEIMBACH ,  Adrian TERSTEEGEN ,  Kai THEDE ,  Reinhold WELKER ,  Beate FAST ,  Arnold PAESSENS ,  Frank DITTMER ,  Rudolph SCHOHE-LOOP ,  Axel HARRENGA ,  Alexander HILLISCH ,  Kerstin HENNINGER ,  Walter HUEBSCH ,  Marcus BAUSER ,  Daniela PAULSEN ,  Alexander BIRKMANN ,  Thomas BRETSCHNEIDER ,  Reiner FISCHER ,  Susanne GRESCHAT ,  Andreas URBAN ,  Steffen WILDUM

IPC: A61K31/5377 ,  C07D491/10 ,  A61K31/438 ,  C07D413/12 ,  C07D307/94 ,  A61K31/34 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D307/94 ,  C07D405/12 ,  C07D407/10 ,  C07D491/10 ,  C07D493/10 ,  C07D495/10

Abstract: The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

Abstract translation: 本发明涉及新的取代的spirotetronic酸（I），其中R 1和R 2与它们所连接的碳原子一起形成式（1），（2），（3）或（4）的基团， ，其中*表示R1和R2键合的碳原子，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是逆转录病毒疾病，在人和/或动物中。

公开(公告)号：US20090181996A1

公开(公告)日：2009-07-16

申请号：US12188940

申请日：2008-08-08

Applicant: Chantal Fuerstner ,  Kai Thede ,  Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Dieter Lang ,  Rudolf Schohe-Loop

Inventor： Chantal Fuerstner ,  Kai Thede ,  Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Dieter Lang ,  Rudolf Schohe-Loop

IPC: A61K31/4709 ,  C07D401/10 ,  C07D471/10 ,  C07D498/10 ,  C07D401/14 ,  A61P31/12

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D471/10

Abstract: The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Abstract translation: 本发明涉及取代的喹诺酮类及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

公开(公告)号：US20080269300A1

公开(公告)日：2008-10-30

申请号：US11661820

申请日：2005-08-30

Applicant: Jens-Kerim Erguden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hutter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hubsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

Inventor： Jens-Kerim Erguden ,  Gunter Karig ,  Ulrich Rosentreter ,  Barbara Albrecht ,  Kerstin Henninger ,  Joachim Hutter ,  Nicole Diedrichs ,  Peter Nell ,  Sabine Arndt ,  Walter Hubsch ,  Andreas Knorr ,  Karl-Heinz Schlemmer ,  Dirk Brohm

IPC: A61K31/4439 ,  C07D417/12 ,  A61P9/12

CPC classification number: C07D417/12

Abstract: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Abstract translation: 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

公开(公告)号：US20080132515A1

公开(公告)日：2008-06-05

申请号：US11579919

申请日：2005-04-23

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Sussmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Frank Sussmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D471/04

Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

公开(公告)号：US20070004735A1

公开(公告)日：2007-01-04

申请号：US10541886

申请日：2003-12-24

Applicant: Ulrich Betz ,  Guy Hewlett ,  Gerald Kleymann ,  Thomas Lampe ,  Tse-I Lin ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Tobias Wunberg ,  Holger Zimmerman ,  Franz Zumpe ,  Wolfgang Bender ,  Kerstin Henninger ,  Axel Jensen ,  Jorg Keldenich ,  Rudolf Schohe-Loop

Inventor： Ulrich Betz ,  Guy Hewlett ,  Gerald Kleymann ,  Thomas Lampe ,  Tse-I Lin ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Tobias Wunberg ,  Holger Zimmerman ,  Franz Zumpe ,  Wolfgang Bender ,  Kerstin Henninger ,  Axel Jensen ,  Jorg Keldenich ,  Rudolf Schohe-Loop

IPC: C12Q1/70 ,  A61K31/50 ,  A61K31/17 ,  C07C271/28

CPC classification number: C07C311/08 ,  C07C275/40 ,  C07D237/04 ,  G01N33/56994 ,  G01N2500/00

Abstract: The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.

Abstract translation: 本发明涉及一种抑制疱疹病毒复制的方法，用于鉴定使用该方法抑制疱疹病毒复制的化合物的方法，具有抗疱疹病毒活性的化合物，其制备方法及其用于制备治疗药物的用途 的疱疹感染。

公开(公告)号：US07115612B2

公开(公告)日：2006-10-03

申请号：US10474916

申请日：2002-04-08

Applicant: Tobias Wunberg ,  Wolfgang Bender ,  Peter Eckenberg ,  Sabine Hallenberger ,  Kerstin Henninger ,  Jörg Keldenich ,  Armin Kern ,  Siegfried Raddatz ,  Jürgen Reefschläger ,  Gunter Schmidt ,  Holger Zimmermann ,  Franz Zumpe ,  Martin Radtke

Inventor： Tobias Wunberg ,  Wolfgang Bender ,  Peter Eckenberg ,  Sabine Hallenberger ,  Kerstin Henninger ,  Jörg Keldenich ,  Armin Kern ,  Siegfried Raddatz ,  Jürgen Reefschläger ,  Gunter Schmidt ,  Holger Zimmermann ,  Franz Zumpe ,  Martin Radtke

IPC: A61K31/497 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4245

CPC classification number: C07D271/06 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention relates to novel sulphonamides of the general formula (I) in which the substituents R1, R2, R3, R4 and A and X are as defined in claim 1 and other claims, and also to processes for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及通式（I）的新型磺酰胺，其中取代基R 1，R 2，R 3，R 3， A 4和A和X如权利要求1和其它权利要求中所定义，并且还涉及其制备方法及其作为抗病毒剂，特别是针对巨细胞病毒的用途。

公开(公告)号：US06500817B1

公开(公告)日：2002-12-31

申请号：US09914554

申请日：2001-08-31

Applicant: Rüdiger Fischer ,  Gerald Kleymann ,  Judith Baumeister ,  Wolfgang Bender ,  Ulrich Betz ,  Peter Eckenberg ,  Gabriele Handke ,  Martin Hendrix ,  Udo Schneider ,  Olaf Weber ,  Kerstin Henninger ,  Axel Jensen ,  Jörg Keldenich

Inventor： Rüdiger Fischer ,  Gerald Kleymann ,  Judith Baumeister ,  Wolfgang Bender ,  Ulrich Betz ,  Peter Eckenberg ,  Gabriele Handke ,  Martin Hendrix ,  Udo Schneider ,  Olaf Weber ,  Kerstin Henninger ,  Axel Jensen ,  Jörg Keldenich

IPC: A61K31426

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/54 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.

Abstract translation: 本发明涉及噻唑基脲衍生物，其制备方法及其作为药物，特别是作为抗病毒药物的用途。