公开(公告)号：US08481689B2

公开(公告)日：2013-07-09

申请号：US12807191

申请日：2010-08-30

Applicant: Kwang-ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

Inventor： Kwang-ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

IPC: C07K16/26 ,  C07K16/00 ,  C12N5/20 ,  C12N15/00 ,  C12N15/87 ,  C07H21/04

Abstract: Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

公开(公告)号：US07968331B2

公开(公告)日：2011-06-28

申请号：US11626523

申请日：2007-01-24

Applicant: Kwang Ho Cheong ,  Chin-sung Park

Inventor： Kwang Ho Cheong ,  Chin-sung Park

IPC: C12M1/14 ,  C12M3/04

CPC classification number: C12M23/12 ,  C12M23/44 ,  C12M35/08 ,  C12M47/04

Abstract: A cell co-culture apparatus and a method of co-culturing and isolating cells using the cell co-culture apparatus to research interactions between cells by direct contact between the cells are provided. The cell co-culture apparatus includes a first substrate including a substrate portion and a plurality of projections provided on a surface of the substrate portion, each of the projections having a top surface for culturing cells, a second substrate including a same number of first channels as a number of the projections such that the channels fit with the projections and substrate surfaces formed between the first channels, and a third substrate including a plurality of second channels corresponding with the top surfaces and a plurality of third channels corresponding with the substrate surfaces.

Abstract translation: 提供了一种细胞共培养装置和使用细胞共培养装置共培养和分离细胞的方法，以通过细胞之间的直接接触来研究细胞之间的相互作用。 细胞共培养装置包括：第一基板，包括基板部分和设置在基板部分的表面上的多个突起，每个突起具有用于培养单元的顶表面;第二基板，包括相同数量的第一通道 作为多个突起，使得通道与形成在第一通道之间的突起和基板表面配合，以及包括与顶表面相对应的多个第二通道的第三基板和对应于基板表面的多个第三通道。

公开(公告)号：US20110104176A1

公开(公告)日：2011-05-05

申请号：US12907604

申请日：2010-10-19

Applicant: Kwang Ho CHEONG ,  Sang-hyun PAEK

Inventor： Kwang Ho CHEONG ,  Sang-hyun PAEK

IPC: A61K39/395 ,  C12N5/12 ,  C07K16/28 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  A61P35/00 ,  A61P25/28 ,  A61P17/06 ,  A61P19/02 ,  A61P9/10 ,  C12P21/04 ,  G01N33/53

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

Abstract: Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

Abstract translation: 本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。 还公开了制备和使用抗体和组合物的方法。

公开(公告)号：US07784911B2

公开(公告)日：2010-08-31

申请号：US11747043

申请日：2007-05-10

Applicant: Kui-hyun Kim ,  Byung-chul Kim ,  Kwang-ho Cheong ,  Su-hyeon Kim

Inventor： Kui-hyun Kim ,  Byung-chul Kim ,  Kwang-ho Cheong ,  Su-hyeon Kim

IPC: B41J2/06

CPC classification number: B01J19/0046 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/0262 ,  B01L2300/0819 ,  B01L2400/027 ,  C40B60/14

Abstract: An apparatus and method which print a biomolecular droplet onto a solid substrate using an electric charge concentration effect comprises: a needle shaped electric field forming electrode which is made of a conductive material, is disposed vertically, and comprises an accommodating area and a nozzle formed on a bottom end of the accommodating area; a solid substrate which is electrically grounded, is disposed below the electric field forming electrode, and comprises a moisture thin film and a target surface onto which the biomolecular droplet is discharged from the nozzle of the electric field forming electrode; and an open circuit type voltage applying unit which is electrically connected to the electric field forming electrode, applies a charge to the electric field forming electrode, and causes the biomolecular droplet to be ejected onto the target surface.

Abstract translation: 使用电荷浓度效应将生物分子液滴印刷到固体基质上的装置和方法包括：由导电材料制成的针形电场形成电极垂直设置，并且包括容纳区域和形成在 容纳区域的底端; 电气接地的固体基板设置在电场形成电极的下方，并且包括湿气薄膜和生物分子液滴从电场形成电极的喷嘴排出的目标表面; 以及与电场形成电极电连接的开路型电压施加单元，向电场形成电极施加电荷，并使生物分子液滴喷射到目标表面上。

公开(公告)号：US20070275435A1

公开(公告)日：2007-11-29

申请号：US11625847

申请日：2007-01-23

Applicant: Kui-hyun KIM ,  Jung-im HAN ,  Jun-hong MIN ,  Kwang-ho CHEONG ,  Byung-chul KIM

Inventor： Kui-hyun KIM ,  Jung-im HAN ,  Jun-hong MIN ,  Kwang-ho CHEONG ,  Byung-chul KIM

IPC: C12Q1/02 ,  C12M1/00

CPC classification number: C12M41/36 ,  C12M41/12 ,  C12M41/26 ,  C12M41/34

Abstract: Disclosed herein are a cell culture chip for monitoring a cell culture in real time and a method of monitoring the cell culture using the cell culture chip. The cell culture chip includes a cell culture chamber formed by side walls of a non-conductive material and a bottom layer of an insulating material and capable of accommodating a cell culture media. The cell culture chip also includes a semiconductor layer disposed under the bottom layer, a metal layer disposed under the semiconductor layer, and an electrode disposed in the cell culture chamber. The cell culture chip monitors both the states of cells attached to walls of the cell culture chamber and the states of cells floating in the cell culture media.

Abstract translation: 本文公开了用于实时监测细胞培养物的细胞培养芯片和使用细胞培养芯片监测细胞培养的方法。 细胞培养芯片包括由非导电材料的侧壁和绝缘材料的底层形成并能够容纳细胞培养基的细胞培养室。 细胞培养芯片还包括设置在底层下方的半导体层，设置在半导体层下方的金属层和设置在细胞培养室中的电极。 细胞培养芯片监测附着于细胞培养室壁的细胞状态和悬浮在细胞培养基中的细胞状态。