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公开(公告)号：US20080177008A1
公开(公告)日：2008-07-24
申请号：US12056197
申请日：2008-03-26
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
IPC: C08L77/06 , A61K31/436
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/606 , C08L77/12 , C08L2666/14
Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US20070202323A1
公开(公告)日：2007-08-30
申请号：US11365392
申请日：2006-02-28
Applicant: Lothar Kleiner , Jessica DesNoyer , Thierry Glauser , Stephen Pacetti , Syed Hossainy
Inventor： Lothar Kleiner , Jessica DesNoyer , Thierry Glauser , Stephen Pacetti , Syed Hossainy
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
Abstract: A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
Abstract translation: 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。
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公开(公告)号：US07166680B2
公开(公告)日：2007-01-23
申请号：US10960381
申请日：2004-10-06
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/606 , C08L77/12 , C08L2666/14
Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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24.发明申请公开(公告)号：US20060093842A1
公开(公告)日：2006-05-04
申请号：US10976551
申请日：2004-10-29
Applicant: Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
Inventor： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC classification number: C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US4800253A
公开(公告)日：1989-01-24
申请号：US89093
申请日：1987-08-25
Applicant: Lothar Kleiner , Martin Matthiesen
Inventor： Lothar Kleiner , Martin Matthiesen
CPC classification number: B01D35/06 , H01C1/1406 , H01C7/027 , F02B3/06
Abstract: Electrical devices which comprise at least one metal electrode and a conductive polymer element in contact therewith, wherein the metal surface which contacts the conductive polymer has a roughened or otherwise treated surface to improve its adhesion to the conductive polymer. The metal electrode is preferably an electrodeposited foil. The conductive polymer preferably exhibits PTC behavior. The devices include heaters and circuit protection devices. The improved adhesion results in improved physical and electrical stability, and broadens the range of conductive polymer compositions which can be used in a number of important applications.
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Patent Agency Ranking
公开(公告)号：US20110239939A1
公开(公告)日：2011-10-06
申请号：US13161343
申请日：2011-06-15
Applicant: Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
Inventor： Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
IPC: B05C11/00
CPC classification number: B05D1/002
Abstract: An apparatus for coating a stent includes an optical feedback system used to align a transducer with a stent strut. Once alignment is achieved, the transducer causes a coating to be ejected onto the stent strut and the transducer is moved along the stent strut to coat the stent strut.
Abstract translation: 用于涂覆支架的装置包括用于将换能器与支架支柱对准的光学反馈系统。 一旦达到定位，换能器将涂层喷射到支架支柱上，并且换能器沿着支架支柱移动以涂覆支架支柱。
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27.发明授权公开(公告)号：US07976891B1
公开(公告)日：2011-07-12
申请号：US11305662
申请日：2005-12-16
Applicant: Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
Inventor： Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
CPC classification number: B05D1/002
Abstract: The apparatus and method use an optical feedback system to align a transducer with a stent strut. Once alignment is achieved, the transducer causes a coating to be ejected onto the stent strut and the transducer is moved along the stent strut to coat the stent strut.
Abstract translation: 该装置和方法使用光学反馈系统将换能器与支架支柱对准。 一旦达到定位，换能器将涂层喷射到支架支柱上，并且换能器沿着支架支柱移动以涂覆支架支柱。
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28.发明申请公开(公告)号：US20080167712A1
公开(公告)日：2008-07-10
申请号：US11970490
申请日：2008-01-07
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC classification number: C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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29.发明授权公开(公告)号：US07390497B2
公开(公告)日：2008-06-24
申请号：US10976551
申请日：2004-10-29
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC classification number: C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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30.发明申请DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF 审中-公开具有多种药物释放速率控制的DEPOT组合物及其用途公开(公告)号：US20070196415A1
公开(公告)日：2007-08-23
申请号：US11553925
申请日：2006-10-27
Applicant: Guohua Chen , Lothar Kleiner , Paul Houston , Jeremy Wright
Inventor： Guohua Chen , Lothar Kleiner , Paul Houston , Jeremy Wright
IPC: A61F2/02
CPC classification number: A61K47/34 , A61K9/0024 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/19 , A61K47/10 , A61K47/14
Abstract: Injectable depot compositions with dual mechanisms of release rate control are provided for sustained beneficial agent delivery in a patient. The composition includes bioerodible particles and an injectable depot vehicle containing a bioerodible polymer in an organic solvent, for forming a bioerodible depot implant after administration to the patient. The bioerodible particles are dispersed in the depot vehicle and contain a beneficial agent and a release rate controlling agent retarding the release of the beneficial agent from the bioerodible particles and from the depot implant.
Abstract translation: 提供具有释放速率控制的双重机制的可注射储库组合物，用于在患者中持续的有益药物递送。 该组合物包括生物可腐蚀颗粒和在有机溶剂中含有生物可腐蚀聚合物的可注射贮存载体，用于在给予患者之后形成生物可浸润的储库植入物。 生物可腐蚀颗粒分散在贮存载体中并含有有益剂和释放速率控制剂，其阻止有益剂从生物可侵蚀颗粒和贮存植入物的释放。
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