公开(公告)号：US11660290B2

公开(公告)日：2023-05-30

申请号：US16780226

申请日：2020-02-03

Applicant: McMaster University

Inventor： Ryan Wylie ,  Vincent Huynh

IPC: A61K31/4188 ,  A61K38/00 ,  A61K47/69 ,  A61K31/4166 ,  A61K31/381 ,  A61K47/66

CPC classification number: A61K31/4188 ,  A61K31/381 ,  A61K31/4166 ,  A61K38/00 ,  A61K47/665 ,  A61K47/6903

Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.

公开(公告)号：US11634795B2

公开(公告)日：2023-04-25

申请号：US16464530

申请日：2017-11-27

Applicant: MCMASTER UNIVERSITY

Inventor： Sumanth Shankar ,  Xiaochun Zeng

IPC: C22C21/10 ,  C22F1/053

Abstract: An aluminum alloy for near net shaped casting of structural components is disclosed. The alloy contains 2 to 10 wt. % Zn, 0.5 to 5 wt. % Mg, 0.5 to 5 wt. %) Fe, optionally Cu, Ti, Sr, Be, Zr, V, Cr, Sc, Na, Si, Mn, Mo, B, and Ni, with balance aluminum. The alloy may be subjected to heat treatment selected from the group consisting of solutionizing, incubation, aging, and two or more heat treatment steps.

公开(公告)号：US20230118553A1

公开(公告)日：2023-04-20

申请号：US17914628

申请日：2020-04-30

Applicant: Kimberly-Clark Worldwide, Inc. ,  MCMASTER UNIVERSITY

Inventor： Xuedong SONG ,  Kaiyuan YANG ,  Todd Ryan Hoare ,  Zohreh Jomeh Farsangi

IPC: C08F220/28 ,  B01J20/26 ,  B01J20/30 ,  B01J20/32

Abstract: Described herein are superabsorbent polymers that are made of copolymers of charged monomer and neutral monomers, where the neutral monomers are alkyl or aryl end-capped neutral and hydrophilic monomers that lack free hydroxyl groups and have a water solubility of at least 200 mg/mL. The copolymer-based superabsorbent polymers have significantly improved absorbency under load. The compositions and methods described herein are useful in a variety of absorbent products.

公开(公告)号：US11512034B2

公开(公告)日：2022-11-29

申请号：US17303462

申请日：2021-05-28

Applicant: McMaster University

Inventor： Jakob Magolan ,  Nicholas Jentsch ,  Xiong Zhang ,  Mathew Piotrowski

IPC: C07C37/14 ,  C07J7/00 ,  B01J21/04 ,  C07D209/08 ,  C07C41/26 ,  C07D307/80 ,  C07C201/12 ,  C07J1/00 ,  C07D311/30 ,  C07D311/32 ,  C07C253/30

Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

公开(公告)号：US11491244B2

公开(公告)日：2022-11-08

申请号：US16618145

申请日：2018-06-04

Applicant: McMaster University ,  Sunnybrook Research Institute

Inventor： John Valliant ,  Naomi Matsuura

IPC: A61B5/055 ,  A61K49/10 ,  C07C19/08

Abstract: The present application is in the field of imaging reagents. In particular, the present application relates to labelled fluorocarbon imaging reagents, the preparation of the reagents, and their uses for imaging such as PET scanning.

公开(公告)号：US20220348936A1

公开(公告)日：2022-11-03

申请号：US17753119

申请日：2020-09-16

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Phillip Marvyn

IPC: C12N15/62 ,  C07K14/705 ,  C07K14/715 ,  C12N5/0783

Abstract: Described herein is a chimeric costimulatory receptor (CCR) molecule having an extracellular domain of a Tumor Necrosis Factor Superfamily member, a transmembrane domain and a cytosolic costimulatory signaling domain from a Tumor Necrosis Factor Receptor Superfamily member is provided. Also provided are pharmaceutical compositions having a T cell expressing CCR and methods and uses of such T cells to treat cancers.

公开(公告)号：US20220331364A1

公开(公告)日：2022-10-20

申请号：US17810238

申请日：2022-06-30

Applicant: Triumvira Immunologics USA, Inc. ,  McMaster University

Inventor： Jonathan Lorne Bramson ,  Christopher W. Helsen ,  Joanne Alicia Hammill ,  Kenneth Anthony Mwawasi

IPC: A61K35/17 ,  C07K14/725 ,  A61P35/00 ,  C07K14/82

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20220317123A1

公开(公告)日：2022-10-06

申请号：US17705000

申请日：2022-03-25

Applicant: McMaster University

Inventor： Yingfu Li ,  Meghan Rothenbroker ,  Erin M. McConnell ,  Carlos D. M. Filipe ,  Jimmy Gu

IPC: G01N33/569 ,  C12N15/113 ,  G01N33/542

Abstract: This disclosure relates to DNAzymes and biosensors for detecting pathogenic bacteria, and in particular, for detecting Legionella pneumophila. This disclosure also provides a method for detecting the presence of Legionella pneumophila in a test sample, comprising: a) contacting said test sample with the DNAzyme or biosensor described herein, wherein the DNAzyme comprises a detectable label; b) allowing cleavage of the DNAzyme if a target is present, thereby releasing the detectable label; and c) measuring a detectable signal if the portion of the DNAzyme comprising the detectable label is released, wherein the RNA cleavage activity of the DNAzyme is activated by a target from Legionella pneumophila.

公开(公告)号：US20220143143A1

公开(公告)日：2022-05-12

申请号：US17429297

申请日：2020-02-07

Applicant: McMaster University ,  Wageningen Universiteit ,  Institut National De Recherche Pour L'Agriculture, L'Alimentation et I'Environnement

Inventor： Jeremy Mark Wells ,  Philippe Langella ,  Harry Sokol ,  Elena Verdu ,  Bruno Lamas

IPC: A61K38/20 ,  A61K31/405 ,  A61K31/553 ,  A61K31/404 ,  A61K31/198 ,  A61K31/352 ,  A61K31/353 ,  A61K31/522 ,  A61K31/465 ,  A61K31/357 ,  A61K31/137 ,  A61K35/741 ,  A61K35/745 ,  A61K35/747 ,  A61K35/744 ,  A61P3/00

Abstract: A method for treating a gluten-induced disease, such as celiac disease, in a subject in need thereof is provided. The method comprises administering to the subject at least one agent that activates aryl hydrocarbon receptor such as AhR agonists, bacterial probiotics with AhR agonist activity, and IL-22 agonists, polypeptides and nucleic acid.

公开(公告)号：US20220142546A1

公开(公告)日：2022-05-12

申请号：US17587646

申请日：2022-01-28

Applicant: McMaster University

Inventor： John Francis CONNOLLY ,  Kyle Ingram RUITER ,  Rober BOSHRA

IPC: A61B5/291 ,  A61B5/16 ,  G06N20/00 ,  A61B5/316 ,  A61B5/377

Abstract: An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are tracked in relation to both pre-attentive brain responses and consciously controlled attention responses.