公开(公告)号：US20110015728A1

公开(公告)日：2011-01-20

申请号：US12835546

申请日：2010-07-13

申请人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

发明人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/005 ,  A61M25/0133 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0141 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/015

摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

摘要翻译： 用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。 该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。 导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤，同时保持良好的操作场稳定性。 输送导管包括刚好靠近远端气囊的偏转部分，以便于在主动脉瓣环内的正确取向中定位假体心脏瓣膜。 导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。 假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

公开(公告)号：US07311656B2

公开(公告)日：2007-12-25

申请号：US10694289

申请日：2003-10-27

申请人： James D. Hughett ,  Robert Michael Webster ,  Douglas Layland Armstrong ,  Byron Lee Boylston ,  Gregg T. Juett ,  Richard A. Hillstead ,  Jack C. Griffis, III ,  Andrew L. Lerohl ,  Mark Dehdashtian ,  Marvin A. Guiles

发明人： James D. Hughett ,  Robert Michael Webster ,  Douglas Layland Armstrong ,  Byron Lee Boylston ,  Gregg T. Juett ,  Richard A. Hillstead ,  Jack C. Griffis, III ,  Andrew L. Lerohl ,  Mark Dehdashtian ,  Marvin A. Guiles

IPC分类号： A61N5/00

CPC分类号： A61N5/1007 ,  A61N2005/1008

摘要： A transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device comprises an integral pump for pressurizing and circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge is provided including a reservoir from which fluid is drawn by the pump and into which fluid is returned after being circulated through the fluid path. The pump may be a peristaltic pump and the fluid cartridge may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge may be of a radiation-blocking material, such as quartz. Further, the treatment cartridge may have a memory for storing and indicating selected information about the treating element.

摘要翻译： 一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中所述转运装置包括用于通过由所述输送装置和相关导管限定的流体路径加压和循环流体的整体泵。 提供了可拆卸的流体盒，其包括储存器，流体由泵从该容器中被抽出，并且在通过流体路径循环之后流体返回到储存器中。 泵可以是蠕动泵，并且流体盒可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。 流体拾取器的长度尺寸使得入口总是浸没在流体中，而与传送装置的取向无关。 还可以设置具有形成流体路径的一部分的内腔的可移除处理盒，并且用于处理盒的存储套筒可以是诸如石英的辐射阻挡材料。 此外，治疗盒可以具有用于存储和指示关于治疗元件的选定信息的存储器。

公开(公告)号：US07066873B2

公开(公告)日：2006-06-27

申请号：US10694097

申请日：2003-10-27

申请人： James D. Hughett ,  Robert Michael Webster ,  Douglas Layland Armstrong ,  Byron Lee Boylston ,  Gregg T. Juett ,  Richard A. Hillstead ,  Jack C. Griffis, III ,  Andrew L. Lerohl ,  Mark Dehdashtian ,  Marvin A. Guiles

发明人： James D. Hughett ,  Robert Michael Webster ,  Douglas Layland Armstrong ,  Byron Lee Boylston ,  Gregg T. Juett ,  Richard A. Hillstead ,  Jack C. Griffis, III ,  Andrew L. Lerohl ,  Mark Dehdashtian ,  Marvin A. Guiles

IPC分类号： A61M3/00 ,  A61N5/00

CPC分类号： A61N5/1007 ,  A61N2005/1008

摘要： A transfer device usable in a system for intraluminal treatment of a selected site in a body of a patient in which the transfer device comprises an integral pump for pressurizing and circulating fluid through a fluid path defined by the transfer device and associated catheter. A removable fluid cartridge is provided including a reservoir from which fluid is drawn by the pump and into which fluid is returned after being circulated through the fluid path. The pump may be a peristaltic pump and the fluid cartridge may include an elongated fluid pick-up having an inlet through which fluid is introduced into the transfer device. The fluid pick-up is sized in length so that the inlet is always submerged in the fluid regardless of the orientation of the transfer device. A removable treatment cartridge having a lumen forming part of the fluid path may also be provided, and a storage sleeve for the treatment cartridge may be of a radiation-blocking material, such as quartz. Further, the treatment cartridge may have a memory for storing and indicating selected information about the treating element.

摘要翻译： 一种可用于管腔内治疗患者体内的选定部位的系统中的转移装置，其中所述转运装置包括用于通过由所述输送装置和相关导管限定的流体路径加压和循环流体的整体泵。 提供了可拆卸的流体盒，其包括储存器，流体由泵从该容器中被抽出，并且在通过流体路径循环之后流体返回到储存器中。 泵可以是蠕动泵，并且流体盒可以包括具有入口的细长流体拾取器，流体通过入口引入到输送装置中。 流体拾取器的长度尺寸使得入口总是浸没在流体中，而与传送装置的取向无关。 还可以设置具有形成流体路径的一部分的内腔的可移除处理盒，并且用于处理盒的存储套筒可以是诸如石英的辐射阻挡材料。 此外，治疗盒可以具有用于存储和指示关于治疗元件的选定信息的存储器。

公开(公告)号：US06702255B2

公开(公告)日：2004-03-09

申请号：US10036634

申请日：2001-11-08

申请人： Mark Dehdashtian

发明人： Mark Dehdashtian

IPC分类号： F16L2900

CPC分类号： A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/0646 ,  Y10T137/7882

摘要： A hemostasis valve for sealing around elongate medical instruments inserted into the body. The valve has an elastomeric valve body adapted to be received with a rigid introducer housing and seal thereagainst. The valve body has a distal end and a proximal end, and a cavity opening at the proximal end to receive the medical instruments. A pair of duckbill walls extends in the distal direction and converges and meets at a slit opening. The slit opening has an H-shape that effectively seals around multiple sizes of medical instruments, from the smallest catheter to the largest bore catheters. The duckbill walls may be planar or curvilinear, and may be reinforced with one or more ribs extending outward therefrom.

摘要翻译： 一种用于密封插入体内的细长医疗器械周围的止血阀。 阀具有弹性体阀体，其适于被容纳有刚性导引器壳体并在其上密封。 阀体具有远端和近端，以及在近端处的腔体，用于接纳医疗器械。 一对鸭嘴壁在远端方向延伸并在狭缝开口处会聚并相遇。 狭缝开口具有H形，其可有效地密封多个尺寸的医疗器械，从最小的导管到最大的孔导管。 鸭嘴壁可以是平面的或曲线的，并且可以用从其向外延伸的一个或多个肋来加强。

公开(公告)号：US06379372B1

公开(公告)日：2002-04-30

申请号：US09694736

申请日：2000-10-23

申请人： Mark Dehdashtian ,  Weiyun Yu ,  Geoffrey H. White ,  Maria Lillian Saravia

发明人： Mark Dehdashtian ,  Weiyun Yu ,  Geoffrey H. White ,  Maria Lillian Saravia

IPC分类号： A61M2900

CPC分类号： A61F2/958 ,  A61M39/06 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/0646 ,  A61M2039/0653 ,  A61M2039/0686

摘要： A system for delivering and implanting a radially expandable endoluminal prosthesis within a body lumen (e.g., blood vessel). The system comprises a) an introducer/dilator assembly, and b) a delivery catheter/loader assembly. The introducer/dilator assembly comprises an elongate tubular introducer sheath which may be provided with a valving assembly mounted on the proximal end thereof. Such valving assembly may incorporate i) a hemostatic valve, ii) a first sealing valve and iii) a second sealing valve, positioned in series, to prevent leakage of body fluid out of the proximal end of the introducer and to permit two or more elongate members (e.g., catheters, guidewires) having differing outer diameters to be inserted through the introducer without leakage of body fluid therefrom. A dilator, which has regionalized differences in stiffness, is initially deployable within the lumen of the introducer to facilitate advancement of the introducer to its desired location within the body. Thereafter, the dilator may be removed from the introducer sheath and the delivery catheter/loader assembly may be attached to the introducer, such that the delivery catheter having the prosthesis mounted thereon may advanced through the introducer, to a desired location within the body. Thereafter, the radial expandable endoluminal prosthesis mounted on the delivery catheter is deployed and implanted by an expansion device (e.g., balloon) formed on the delivery catheter. The delivery catheter may incorporate one or more outflow apertures at specific location(s) to facilitate injection of radiographic contrast medium in a manner which will check for leakage around the endoluminal prosthesis, after the endoluminal prosthesis has been radially expanded and implanted.

摘要翻译： 用于在体腔（例如，血管）内输送和植入径向可膨胀的腔内假体的系统。 该系统包括a）导引器/扩张器组件，以及b）输送导管/装载器组件。 导引器/扩张器组件包括细长的管状导引器护套，其可以设置有安装在其近端上的阀组件。 这种阀门组件可以包括i）止血阀，ii）第一密封阀和iii）串联定位的第二密封阀，以防止体液从引导器的近端泄漏出来并且允许两个或更多细长 具有不同外径的构件（例如，导管，导丝）插入穿过导引器而不会从其体内流体泄漏。 具有区域性的刚度差异的扩张器最初可部署在导引器的内腔内，以便于将导引器推进到其体内所需的位置。 此后，扩张器可以从引导器护套中移除，并且输送导管/装载器组件可以附接到导引器，使得具有安装在其上的假体的输送导管可以通过导引器前进到身体内的期望位置。 此后，安装在输送导管上的径向可膨胀的腔内假体通过形成在输送导管上的膨胀装置（例如气囊）展开和植入。 递送导管可以在特定位置包括一个或多个流出孔，以便于在腔内假体已被径向扩张和植入之后以一种将检查腔内假体周围的渗漏的方式注射射线照相造影剂。

公开(公告)号：US06375675B2

公开(公告)日：2002-04-23

申请号：US09819454

申请日：2001-03-27

申请人： Mark Dehdashtian ,  Geoffrey H. White ,  Weiyun Yu

发明人： Mark Dehdashtian ,  Geoffrey H. White ,  Weiyun Yu

IPC分类号： A61F206

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/95 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2220/0033 ,  A61F2250/0048 ,  A61F2250/0098

摘要： Methods and apparatus for placing a bifurcated aortic graft, with extensions, into a body lumen. An aortic graft is provided with a unique combination of self-expanding a balloon expandable wires. The aortic graft is bifurcated and includes ipsilateral and contralateral legs. Two extension grafts are provided for frictional engagement with the legs of the aortic graft. For placement of the bifurcated aortic graft with extensions, an introducer assembly including a dilator and a sheath assembly provides access for the introduction of a main catheter and a directional catheter. The main catheter is provided for deployment of the bifurcated aortic graft within the lumen of a vessel. A balloon is provided on the main catheter for expanding the balloon-expandable wires of the aortic graft. The directional catheter, which includes a deflecting spring portion, permits placement of a guidewire through the ipsilateral leg and into the contralateral leg of the aortic graft. In turn, a second introducer sheath and a second catheter assembly are provided contralaterally for introduction of a graft extension. Upon balloon-expansion, the graft extension is frictionally engaged with the contralateral leg of the aortic graft. A third catheter assembly including a second extension graft is provided for introduction of the extension graft and balloon-expansion thereof for frictional engagement with the ipsilateral leg of the graft.

摘要翻译： 将具有延伸部的分叉主动脉移植物放置在体腔中的方法和装置。 主动脉移植物具有自扩张气囊可扩展电线的独特组合。 主动脉移植物分叉，包括同侧和对侧腿。 提供两个延伸移植物用于与主动脉移植物的腿摩擦接合。 为了安置具有延伸部的分叉主动脉移植物，包括扩张器和护套组件的导引器组件提供用于引入主导管和定向导管的通路。 提供主导管用于将分叉的主动脉移植物部署在血管的内腔内。 在主导管上设置有用于扩张主动脉移植物的球囊可扩张线的球囊。 包括偏转弹簧部分的定向导管允许将导丝穿过同侧腿并进入主动脉移植物的对侧腿部。 反过来，第二引导器护套和第二导管组件相对地设置以引入移植物延伸部。 气囊膨胀时，移植物延伸部与主动脉移植物的对侧腿摩擦接合。 提供包括第二延伸移植物的第三导管组件，用于引入延伸移植物和气囊扩张，以与移植物的同侧腿摩擦接合。

公开(公告)号：US06368345B1

公开(公告)日：2002-04-09

申请号：US09204699

申请日：1998-12-03

申请人： Mark Dehdashtian ,  Geoffrey H. White ,  Weiyun Yu

发明人： Mark Dehdashtian ,  Geoffrey H. White ,  Weiyun Yu

IPC分类号： A61F206

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/95 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2220/0033 ,  A61F2250/0048 ,  A61F2250/0098

摘要： Methods and apparatus for placing a bifurcated aortic graft, with extensions, into a body lumen. An aortic graft is provided with a unique combination of self-expanding a balloon expandable wires. The aortic graft is bifurcated and includes ipsilateral and contralateral legs. Two extension grafts are provided for frictional engagement with the legs of the aortic graft. For placement of the bifurcated aortic graft with extensions, an introducer assembly including a dilator and a sheath assembly provides access for the introduction of a main catheter and a directional catheter. The main catheter is provided for deployment of the bifurcated aortic graft within the lumen of a vessel. A balloon is provided on the main catheter for expanding the balloon-expandable wires of the aortic graft. The directional catheter, which includes a deflecting spring portion, permits placement of a guidewire through the ipsilateral leg and into the contralateral leg of the aortic graft. In turn, a second introducer sheath and a second catheter assembly are provided contralaterally for introduction of a graft extension. Upon balloon-expansion, the graft extension is frictionally engaged with the contralateral leg of the aortic graft. A third catheter assembly including a second extension graft is provided for introduction of the extension graft and balloon-expansion thereof for frictional engagement with the ipsilateral leg of the graft.

公开(公告)号：US06231563B1

公开(公告)日：2001-05-15

申请号：US09117092

申请日：1999-04-14

申请人： Geoffrey H. White ,  Weiyun Yu ,  Mark Dehdashtian

发明人： Geoffrey H. White ,  Weiyun Yu ,  Mark Dehdashtian

IPC分类号： A61M2500

CPC分类号： A61M25/01 ,  A61M25/09 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/018

摘要： An intraluminal catheter for directing a guidewire and/or catheter in a desired direction within a bodily vessel or cavity. The intraluminal catheter has a first elongate tubular member and a support means which can comprise a second elongate tubular member that can pass over a main support guidewire. The catheter acts as a platform as the guidewire is passed through the first elongate tubular member and is deflected transversely outwardly by an angled surface through an aperture. A second intraluminal catheter has a first elongate tubular member and a support means comprising a second elongate tubular member. The first elongate tubular member has a main portion and an end portion, with the end portion being deflectable relative to the locus of the main portion so as to direct the guidewire passing through the end portion in a desired direction in the bodily vessel.

摘要翻译： 一种用于将导丝和/或导管沿着所需方向引导到体内血管或空腔内的管腔内导管。 管腔内导管具有第一细长管状构件和支撑装置，该支撑装置可包括可穿过主支撑导丝的第二细长管状构件。 当导丝穿过第一细长管状构件时，导管用作平台，并且通过孔径横向向外偏转成角度的表面。 第二腔内导管具有第一细长管状构件和包括第二细长管状构件的支撑装置。 第一细长管状构件具有主体部分和端部部分，其端部相对于主要部分的轨迹是可偏转的，以便引导导线沿着所需方向在身体容器中穿过端部。

公开(公告)号：US6024729A

公开(公告)日：2000-02-15

申请号：US038500

申请日：1998-03-10

申请人： Mark Dehdashtian ,  Gordon E. Atkinson

发明人： Mark Dehdashtian ,  Gordon E. Atkinson

IPC分类号： A61M25/01 ,  A61M25/00 ,  A61M39/06 ,  A61M5/00

CPC分类号： A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M25/0097

摘要： A hemostasis valve assembly adapted for use within a catheter introducer is disclosed. The valve assembly includes first, second and third sealing members wherein the second sealing member comprises a guide wire seal. The guide wire seal includes a plurality of lip members defining two pairs of diametrically opposed slits and an aperture intersecting at least one of the slits. The aperture is adapted to sealing engage a small diameter guide wire for preventing fluid flow out of the catheter introducer through the valve assembly, while the slits allow for the passage of a large diameter elongated member or catheter. Two pairs of diametrically opposed pre-load ribs extend radially towards the aperture for pressing the lip members together in sealing engagement. A substantially spherical inner surface is provided for guiding the guide wire to the aperture.

摘要翻译： 公开了适于在导管导引器内使用的止血阀组件。 阀组件包括第一，第二和第三密封构件，其中第二密封构件包括导丝密封件。 导丝密封件包括限定两对直径相对的狭缝的多个唇形构件和与至少一个狭缝相交的孔。 孔口适于密封接合小直径导丝，以防止流体通过阀组件流出导管导引器，同时狭缝允许大直径细长构件或导管通过。 两对直径相对的预加载肋径向向孔径延伸，用于将密封构件按压密封在一起。 提供基本上球形的内表面以将导丝引导到孔。