摘要:
Oxetanocin derivatives represented by formula: ##STR1## wherein X represents H or ##STR2## or a pharmacologically acceptable salt thereof exhibit an anti-viral activity. Anti-viral compositions comprising the oxetanocin derivatives or their pharmacologically acceptable salts as the effective ingredient are also provided.
摘要:
A communication module according to the present invention includes a substrate, a laser element and a light receiving element provided on a front surface of the substrate and separating from each other, a transparent resin package collectively sealing the laser element and the light receiving element, and a diffusion unit provided to be opposed to a light emitting surface of the laser element at a prescribed distance for diffusing a laser beam emitted by the laser element, while the distance T between the laser element and the light receiving element satisfies the following formula (1): T≧t1·tan θ+(t1+t2)·tan θ′ . . . (1) (in the formula (1), t1 represents the distance between the light emitting surface of the laser element and the diffusion unit, θ represents the maximum angle of emission of the laser element, t2 represents the difference between the height from the front surface of the substrate up to the light emitting surface and the height up to alight receiving surface of the light receiving element, and θ′ represents the maximum diffusion angle of the diffusion unit.)
摘要:
A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin and linked via an ester bond is provided.
摘要:
Enzymes in the body vary among different species, and also vary among individuals of the same species. Thus, it has been demanded to develop a novel steroid-containing pharmaceutical preparation which can release a drug in a manner independent of the enzymes present in the body, and which is expected to have an efficacious therapeutic effect.Disclosed is a high-molecular weight conjugate of a steroid, comprising a structure in which a carboxylic acid group of a polymer having a polyethylene glycol moiety and a succinic acid monoamide moiety having two or more succinic acid monoamide units is ester-bonded to a hydroxy group in the steroid.
摘要:
[PROBLEMS] A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded.[MEANS FOR SOLVING PROBLEMS] A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin and linked via an ester bond is provided.
摘要:
It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.
摘要:
A peripheral device and method are provided for reliably updating and checking firmware or other coded information stored within a nonvolatile memory of the device. The device comprises a microcontroller and a memory with a fixed part and an updateable part. Both the fixed part and the updateable part store firmware. When firmware in the updateable part is updated (such as by using a USB connection with a host PC), a first error detection code is generated and stored in the updateable part. As part of an initialization procedure, the firmware stored in the fixed part generates a second error detection code based on the updated firmware stored in the updateable part and compares the second error detection code to the first error detection code stored in the updateable part. If the error detection codes indicate that the firmware stored in the updateable part is valid, the microcontroller uses the firmware stored in the updateable part to operate the device; otherwise, the microcontroller uses firmware stored in the fixed part to operate the device.
摘要:
A device controller for controlling the operation of the drive device. The controller includes a microprocessor, a volatile memory, and a non-volatile memory. The non-volatile memory stores an uncompressed decompression program and a compressed device operating program. The microprocessor automatically decompresses the device operating program by executing the decompression program and stores the decompressed device operating program into the volatile memory when the drive is powered up or reset. The microprocessor then executes the device operating program stored in the volatile memory which has a faster data access rate than the non-volatile memory. As the device operating program is stored in a compressed form, the size of the non-volatile memory is minimized. The present invention may also reduce the size of a non-volatile memory for storing data used in a device controller.
摘要:
It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.