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    System for associating a function to an entity capable of communicating data across an interface
    8.
    发明授权
    System for associating a function to an entity capable of communicating data across an interface 失效
    用于将功能与能够通过接口通信数据的实体相关联的系统

    公开(公告)号：US06820166B2

    公开(公告)日：2004-11-16

    申请号：US09757314

    申请日：2001-01-09

    申请人： Masayuki Kitagawa

    发明人： Masayuki Kitagawa

    IPC分类号： G06F1300

    CPC分类号： G06F13/4068

    摘要： The present invention relates to a method and system for selecting one of the two functions. The system in accordance with one embodiment of the invention includes a first entity that has a host function and a device function, and a second entity that has at least one of the two functions. The system further includes a detector and a selecting mechanism. The detector detects the second entity when the first entity is connected to the second entity. The selecting mechanism responds to an output of the detector and selects one out of the host and device functions of the first entity.

    摘要翻译： 本发明涉及一种用于选择两个功能之一的方法和系统。 根据本发明的一个实施例的系统包括具有主机功能和设备功能的第一实体以及具有两个功能中的至少一个功能的第二实体。 该系统还包括检测器和选择机构。 当第一实体连接到第二实体时，检测器检测第二实体。 选择机制响应于检测器的输出，并从第一实体的主机和设备功能中选出一个。

    Polymer Conjugate Of Bioactive Substance Having Hydroxy Group
    9.
    发明申请
    Polymer Conjugate Of Bioactive Substance Having Hydroxy Group 有权
    具有羟基的生物活性物质的共轭物

    公开(公告)号：US20120116051A1

    公开(公告)日：2012-05-10

    申请号：US13319175

    申请日：2010-05-12

    申请人： Masayuki Kitagawa ,  Chieko Seno ,  Keiko Ebara ,  Kazutoshi Takashio

    发明人： Masayuki Kitagawa ,  Chieko Seno ,  Keiko Ebara ,  Kazutoshi Takashio

    IPC分类号： C08H1/00 ,  A61P9/10 ,  A61P17/14 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C08G69/10 ,  A61K31/167 ,  A61K31/19 ,  A61K31/195 ,  A61K31/337 ,  A61K31/365 ,  A61K31/4745 ,  A61K31/52 ,  A61K31/573 ,  A61K31/704 ,  A61K31/7052 ,  A61K31/7068 ,  A61K47/60 ,  A61K47/645 ,  C08G69/40 ,  C08G69/48

    摘要： A polymer conjugate of a physiologically active substance, which enables drug release independent of a biological enzyme and can be expected to have a high therapeutic effect, is demanded.Provided is a polymer conjugate of a physiologically active substance, comprising a block copolymer of a polyethylene glycol moiety and a polymer having two or more carboxy groups, in which a substituent represented by general formula (I) or general formula (II) is linked to at least one of the side-chain carboxy groups of the block copolymer via an amide bond [in the formula, R8 and R9 each independently are hydrogen atom or (C1-C6)alkyl which may have a substituent, R10 is hydrogen atom, (C1-C40)alkyl which may have a substituent, (C1-C40) aralkyl group which may have a substituent, an aromatic group which may have a substituent, an amino acid residue having a protected carboxy group, or a sugar residue which may have a substituent, CX—CY represents CH—CH or C═C (double bond), and A represents a residue obtained by removing, from a physiologically active substance having one or more hydroxy groups, one of the one or more hydroxy groups].

    摘要翻译： 需要生物活性物质的聚合物缀合物，其使药物释放与生物酶无关并且可以预期具有高治疗效果。 提供了一种生理活性物质的聚合物缀合物，其包含聚乙二醇部分和具有两个或更多个羧基的聚合物的嵌段共聚物，其中由通式（I）或通式（II）表示的取代基与 嵌段共聚物中的至少一个侧链羧基通过酰胺键[在式中，R8和R9各自独立地为氢原子或可具有取代基的（C1-C6）烷基，R10为氢原子（ 可以具有取代基的C 1 -C 40的烷基，可以具有取代基的（C 1〜C 40）芳烷基，可以具有取代基的芳香族基，具有被保护的羧基的氨基酸残基， 取代基，CX-CY表示CH-CH或C = C（双键），A表示通过从具有一个或多个羟基的生理活性物质除去一个或多个羟基之一而获得的残基]。

    POLYMER CONJUGATE OF TAXANE
    10.
    发明申请
    POLYMER CONJUGATE OF TAXANE 有权
    TAXANE的聚合物

    公开(公告)号：US20100234537A1

    公开(公告)日：2010-09-16

    申请号：US12225230

    申请日：2007-03-22

    申请人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Takeshi Onda

    发明人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Takeshi Onda

    IPC分类号： C08G69/48

    CPC分类号： C08G65/33324 ,  A61K31/337 ,  A61K47/60 ,  A61K47/645 ,  C08G65/329 ,  C08G69/10 ,  C08G69/40 ,  C08G69/48 ,  C08L2203/02

    摘要： [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility.[Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.

    摘要翻译： [问题]为了提供能够以不依赖生物酶的方式释放药物的新型紫杉烷衍生物，预期具有有效的治疗功效，并且具有水溶性。 解决问题的手段公开了紫杉烷的聚合物缀合物，其包含具有聚乙二醇部分和两个或多个琥珀酸单酰胺部分的聚合物和紫杉烷，其中聚合物中的羧酸酯基团和 紫杉烷通过酯键相互结合。