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    X-ray device having a dilation structure for delivering localized radiation to an interior of a body
    23.
    发明授权
    X-ray device having a dilation structure for delivering localized radiation to an interior of a body 失效
    具有用于将局部辐射传送到身体内部的扩张结构的X射线装置

    公开(公告)号：US6095966A

    公开(公告)日：2000-08-01

    申请号：US27010

    申请日：1998-02-20

    Applicant: Victor I. Chornenky ,  Michael R. Forman ,  Robert A. Ganz

    Inventor： Victor I. Chornenky ,  Michael R. Forman ,  Robert A. Ganz

    IPC: A61N5/10 ,  H01J35/32

    CPC classification number: A61N5/1001 ,  H01J35/32 ,  A61N5/1002 ,  H01J2235/205

    Abstract: Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for use of such a device. The device includes an anode and a cathode, disposed within a vacuum housing. The device further includes a balloon coupled to and circumferentially surrounding the vacuum housing, and a fluid loop for circulating a cooling fluid proximate to the vacuum housing. A method for delivering localized x-ray radiation to an interior passage of a body is also described, including the steps of positioning an x-ray device at the passage to be treated and applying a high voltage to the x-ray producing unit to produce localized x-ray radiation.

    Abstract translation: 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及使用这种装置的方法。 该装置包括设置在真空壳体内的阳极和阴极。 该装置还包括联接到并围绕真空壳体并围绕真空壳体的气囊，以及用于使靠近真空壳体的冷却流体循环的流体回路。 还描述了将局部X射线辐射递送到身体的内部通道的方法，包括以下步骤：将X射线装置定位在待治疗的通道处，并向x射线产生单元施加高电压以产生 局部x射线辐射。

    Device and method for intracavitary cancer treatment
    25.
    发明授权
    Device and method for intracavitary cancer treatment 失效
    腔内癌症治疗的装置和方法

    公开(公告)号：US6036631A

    公开(公告)日：2000-03-14

    申请号：US036942

    申请日：1998-03-09

    Applicant: Jonathan R. McGrath ,  Michael R. Forman

    Inventor： Jonathan R. McGrath ,  Michael R. Forman

    IPC: A61M36/04 ,  A61N5/10 ,  A61N5/00

    CPC classification number: A61N5/1014 ,  A61N2005/1005

    Abstract: A device and method for treatment of cancerous tissue from a body conduit involves insertion into the body conduit of a probe including an energy-emitting element for delivering ionizing energy. The body conduit is dilated to decrease a distance between at least a portion of the body conduit and the cancerous tissue. Ionizing energy is delivered from the energy-emitting element to selectively injure the cancerous tissue, with dilation of the body conduit minimizing the radiation dose delivered to the body conduit for a given radiation dose delivered to the cancerous tissue.

    Abstract translation: 用于治疗来自身体导管的癌组织的装置和方法包括插入到包括用于传递电离能的能量发射元件的探针的体导管中。 身体导管被扩张以减小身体导管的至少一部分与癌组织之间的距离。 电离能量从能量发射元件输送以选择性地损伤癌组织，由于体内导管的扩张使得递送至身体导管的辐射剂量对于递送至癌组织的给定辐射剂量是最小的。

    Miniature x-ray device having cold cathode
    27.
    发明授权
    Miniature x-ray device having cold cathode 失效
    具有冷阴极的微型x射线装置

    公开(公告)号：US5854822A

    公开(公告)日：1998-12-29

    申请号：US900609

    申请日：1997-07-25

    Applicant: Victor I. Chornenky ,  Dale L. Schreiner ,  Michael R. Forman

    Inventor： Victor I. Chornenky ,  Dale L. Schreiner ,  Michael R. Forman

    IPC: H01J35/06 ,  A61N5/10 ,  H01J35/20 ,  H01J35/32

    CPC classification number: A61N5/1001 ,  H01J35/32 ,  A61N5/1002

    Abstract: Generally, the present invention provides a device for insertion into a body and delivery of x-ray radiation, and a method for fabricating such a device. The device includes a connector, the vacuum housing, an anode and a cathode having a granular surface and being composed of a material that allows it to act as a getter. The cathode may also contain diamond material in one embodiment.

    Abstract translation: 通常，本发明提供了一种用于插入身体和X射线辐射的输送的装置，以及用于制造这种装置的方法。 该装置包括连接器，真空壳体，具有颗粒表面的阳极和阴极，并且由允许其用作吸气剂的材料组成。 在一个实施方案中，阴极还可以含有金刚石材料。

    Laser ablation of angioplasty catheters and balloons
    29.
    发明授权
    Laser ablation of angioplasty catheters and balloons 失效
    血管成形术导管和气囊的激光消融

    公开(公告)号：US5733301A

    公开(公告)日：1998-03-31

    申请号：US582371

    申请日：1996-01-11

    Applicant: Michael R. Forman

    Inventor： Michael R. Forman

    IPC: A61M25/00 ,  A61M29/02 ,  A61M29/00

    CPC classification number: A61M25/1029 ,  A61M25/104 ,  A61M2025/1031

    Abstract: A dilatation balloon is fabricated according to a process that yields high hoop strength and uniformity in balloon wall thickness. A length of tubing is axially elongated and radially expanded in a form to provide the requisite biaxial orientation and strength. Then, an excimer laser is used to remove the polymeric material by photo-chemical ablation, virtually without thermal effects. Dilatation balloon walls are thinned primarily along tapered sections between proximal and distal balloon stems and a medial working section of the balloon. Material removal, particularly near the balloon stems, enables tighter wrapping of the balloon for a reduced delivery profile, and reduces rigidity near the stems for better maneuverability of the catheter in tortuous passageways. The balloon tapered sections are reduced to a wall thickness substantially equal to that of the medial section. Alternatively, an array of grooves is formed in each tapered section.

    Abstract translation: 根据产生高气球强度和球囊壁厚度均匀性的方法制造扩张球囊。 一段长度的管材是轴向伸长的并以一种形式径向扩张以提供必要的双轴取向和强度。 然后，准分子激光器被用于通过光化学消融去除聚合物材料，实际上没有热效应。 扩张气球壁主要在近端和远端气囊杆之间的锥形部分和气囊的内侧工作部分之间变薄。 特别是气囊杆附近的材料去除使得球囊能够更紧密地包裹以减少输送轮廓，并且降低杆附近的刚度，从而更好地操纵导管在曲折通道中的机动性。 气囊锥形部分被还原成基本上等于中间部分的壁厚。 或者，在每个锥形部分中形成有一组凹槽。

    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
    30.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel 失效
    含有聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法，该水凝胶与至少一种其它不同的聚合物水凝胶

    公开(公告)号：US5576072A

    公开(公告)日：1996-11-19

    申请号：US382459

    申请日：1995-02-01

    Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC: A61L29/04 ,  A61L29/08 ,  B05D7/00 ,  B05D7/02 ,  C08G18/10 ,  C08G18/48 ,  C08G18/75 ,  C09D175/04 ,  B05D3/00 ,  B29C71/02 ,  C04B41/00 ,  H05H1/00

    CPC classification number: B05D7/54 ,  A61L29/049 ,  A61L29/085 ,  B05D7/02 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/755 ,  C08G18/758 ,  C09D175/04 ,  C08G2210/00 ,  Y10T428/31551

    Abstract: A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    Abstract translation: 制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

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