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公开(公告)号：US06799075B1
公开(公告)日：2004-09-28
申请号：US08701764
申请日：1996-08-22
IPC分类号： A61B1818
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： A catheter for emitting radiation is disclosed, comprising a catheter shaft and an x-ray unit attached to the distal end of the catheter shaft. The x-ray unit comprises an anode and a cathode coupled to an insulator to define a vacuum chamber. The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4 mm and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.
摘要翻译： 公开了一种用于发射辐射的导管，包括导管轴和附接到导管轴的远端的x射线单元。 x射线单元包括阳极和阴极，其耦合到绝缘体以限定真空室。 阴极优选为例如涂覆有碳化钛的石墨或石墨的场致发射阴极。 阳极优选为钨，绝缘体优选为热解氮化硼。 X射线单元优选地通过同轴电缆耦合到电压源。 阳极优选为重金属，例如钨。 阴极也可以是铁电材料。 x射线单元的直径可以小于约4毫米，长度小于约15毫米。 还公开了导管的使用方法。 本发明的导管可用于照射血管成形术程序的部位以防止再狭窄。 它也可以用于治疗身体的任何血管，腔或腔中的其他病症。
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2.发明授权公开(公告)号：US07338487B2
公开(公告)日：2008-03-04
申请号：US10010911
申请日：2001-11-20
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译： 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。 该器件包括具有薄的金刚石膜作为阴极的阴极结构。 该装置还包括真空壳体和阳极。 描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。
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公开(公告)号：US06503224B1
公开(公告)日：2003-01-07
申请号：US09631750
申请日：2000-08-04
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61B2017/00685 , A61M1/101 , A61M1/1018 , A61M1/1036 , A61M1/122 , A61M1/125 , A61M1/127 , A61M25/00 , A61M29/02 , A61M2025/1095
摘要： A balloon catheter having a perfusion lumen communicating with a blood vessel, and a magnetically driven impeller disposed in the perfusion lumen to increase blood flow through the catheter and the arteries.
摘要翻译： 具有与血管连通的灌注腔的气囊导管和设置在灌注腔内的磁驱动叶轮以增加通过导管和动脉的血流。
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4.发明授权Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated polymer and metal substrate materials, and coated medical devices 有权用于制备光滑，坚固粘附的亲水性聚氨酯水凝胶涂层，涂覆聚合物和金属基底材料以及涂覆的医疗装置的方法公开(公告)号：US06265016B1
公开(公告)日：2001-07-24
申请号：US09531925
申请日：2000-03-21
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： B05D302
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08G2230/00 , C08J7/04 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678 , A61L31/145 , A61L29/145 , C08L75/04 , C08G18/307 , C08G18/3225
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译： 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。
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5.发明授权Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated metal substrate materials, and coated medical devices 失效用于制备光滑，坚固粘附，亲水性聚氨酯水凝胶涂层，涂覆金属基材和涂覆医疗装置的方法
公开(公告)号：US6030656A
公开(公告)日：2000-02-29
申请号：US126375
申请日：1998-03-24
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译： 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。
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6.发明授权Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia 失效组合电离辐射和放射增敏剂递送装置和抑制增生的方法公开(公告)号：US07018371B2
公开(公告)日：2006-03-28
申请号：US09851372
申请日：2001-05-07
申请人： Michael R. Forman
发明人： Michael R. Forman
CPC分类号： A61K51/1282 , A61M25/002 , A61M25/10 , A61M25/1011 , A61M2025/105 , A61M2025/1052 , A61M2025/1097 , A61N5/1001 , A61N2005/1003 , A61N2005/1004
摘要： The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and radiosensitizer delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, banier, coating, infusion lumen, stent, graft, or reservoir for releasing an radiosensitizer to the body lumen.
摘要翻译： 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供与电离辐射组合的受控放射增敏剂递送至患者脉管系统内的选定位置，以减少和/或抑制再狭窄和增生率与增加的功效。 在一个实施方案中，用于抑制增生的组合辐射和放射增敏剂递送导管包括具有近端和远端的导管主体，可耦合到导管体的用于对体腔施加辐射剂量的电离辐射源，以及多孔材料， 基质，膜，放射线，涂层，输液腔，支架，移植物或储器，用于将放射增敏剂释放到体腔。
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7.发明授权Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia 失效组合x射线辐射和药物递送装置和抑制增生的方法公开(公告)号：US06537195B2
公开(公告)日：2003-03-25
申请号：US09850721
申请日：2001-05-07
申请人： Michael R. Forman
发明人： Michael R. Forman
IPC分类号： A61N500
CPC分类号： A61N5/1001 , A61K51/1282 , A61M25/1011 , A61M2025/105 , A61M2025/1052 , A61N2005/1003 , A61N2005/1004
摘要： The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled drug delivery in combination with x-ray radiation delivery to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and agent delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an agent to the body lumen.
摘要翻译： 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供了将x射线辐射递送到患者脉管系统内的选定位置的受控药物递送，以减少和/或抑制再狭窄和增生的发生率。 在一个实施方案中，用于抑制增生的组合辐射剂和药剂输送导管包括具有近端和远端的导管主体，可与导管主体耦合的X射线管，用于向体腔施加辐射剂量，以及多孔材料 ，基质，膜，屏障，涂层，输液腔，支架，移植物或储存器，用于将药剂释放到体腔。
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8.发明授权公开(公告)号：US06377846B1
公开(公告)日：2002-04-23
申请号：US08806244
申请日：1997-02-21
IPC分类号： A61N130
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32 , H01J2235/205
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译： 通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。 该器件包括具有薄的金刚石膜作为阴极的阴极结构。 该装置还包括真空壳体和阳极。 描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。
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9.发明授权Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated metal substrate materials, and coated medical devices 失效滑溜，强力粘附亲水性聚氨酯水凝胶涂层，涂层金属基材和涂层医疗器械
公开(公告)号：US6040058A
公开(公告)日：2000-03-21
申请号：US126374
申请日：1998-08-27
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译： 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶的涂层，使得涂料组合物坚韧地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。
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公开(公告)号：US5776100A
公开(公告)日：1998-07-07
申请号：US719999
申请日：1996-09-25
申请人： Michael R. Forman
发明人： Michael R. Forman
CPC分类号： A61M25/09 , A61M2025/09008 , A61M2025/091 , A61M2025/09175
摘要： An infusion guide wire of superelastic nickel titanium is disclosed comprising a lumen extending longitudinally through the wire and a distal portion with a smaller outer diameter than a proximal portion. One or more intermediate portions of intermediate outer diameters can be provided, as well. An occlusion balloon can be attached to the distal portion, and inflated through the lumen. Alternatively, or in conjunction with the occlusion balloon, drugs or other agents can be delivered through the lumen.
摘要翻译： 公开了一种超弹性镍钛的输液引导线，其包括纵向延伸穿过线的内腔和具有比近侧部分更小的外径的远侧部分。 也可以设置中间外径的一个或多个中间部分。 闭塞气囊可以附着到远端部分，并且通过内腔充气。 或者，或者与闭塞气囊一起，药物或其它药剂可以通过管腔输送。
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