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公开(公告)号：US20160279193A1
公开(公告)日：2016-09-29
申请号：US15034917
申请日：2014-11-06
Inventor： Marit Otterlei
Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.
Abstract translation: 在某些方面，本发明的试剂和组合物可以用作单一试剂。 在本发明的其它方面，本发明的药剂和组合物可以与一种或多种另外的活性剂如激酶抑制剂结合使用。
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公开(公告)号：US20250013471A1
公开(公告)日：2025-01-09
申请号：US18694318
申请日：2022-09-23
Inventor： Magnus Jahre , Björn Gottschall , Lieven Eeckhout
Abstract: Profiling circuitry for a processor includes state-determining circuitry that is configured to access information stored by the processor for committing inflight instructions in program order, and to use this information to determine a commit state of the processor. The profiling circuitry also has sampling circuitry which is configured, when the processor is in a first commit state, to output sample data to a sample register or a memory that identifies one or more instructions that are next to be committed by the processor, and, when the processor is in a second commit state, to output sample data to the sample register or memory that identifies an instruction that was last committed by the processor.
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公开(公告)号：US20250009659A1
公开(公告)日：2025-01-09
申请号：US18709728
申请日：2022-11-10
Applicant: UNIVERSITE DE RENNES , Centre National de la Recherche Scientifique , École Nationale Supérieure de Chimie de Rennes , Institut National des Sciences Appliquées de Rennes , Norwegian University of Science and Technology
Inventor： Thierry BENVEGNU , Thomas VIVES , Matthieu HICGUET , Sébastien SIMON , Johan SJÖBLOM
IPC: A61K9/127 , C07C69/608 , C07C219/10 , C07D249/04 , C08G65/00
Abstract: The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.
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公开(公告)号：US12108963B2
公开(公告)日：2024-10-08
申请号：US17186460
申请日：2021-02-26
Inventor： Per Magnus Haram
CPC classification number: A61B17/32002 , A61B2017/00477 , A61B2017/320032
Abstract: A surgical cutting tool for keyhole surgery comprises: a handle 2 at a proximal end of the tool; an elongate member 4 extending from the handle to a distal end of the tool; and a saw 6 at the distal end of the tool, the saw being supported by the elongate member 4. The elongate member 4 has a length allowing for insertion of the saw 6 into the body by a distance of at least 150 mm. The tool is arranged for insertion of the saw 6 into the body during keyhole surgery; and the saw 6 is able to cut bone when pressed against the bone.
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公开(公告)号：US20230347314A1
公开(公告)日：2023-11-02
申请号：US18026683
申请日：2021-09-16
Inventor： Jon Otto FOSSUM , Josef BREU , Kristoffer HUNVIK , Patrick LOCH
CPC classification number: B01J20/12 , B01J20/3285 , B01D2253/11 , B01D2256/245 , B01D2257/504
Abstract: A smectite or vermiculite clay mineral in the form of a powder and having a plurality of layers wherein each layer comprises one octahedral type sheet sandwiched between two tetrahedral type sheets; wherein at least every other layer of said clay mineral comprises a hydroxide species comprising a cation selected from the group consisting of Ni, Mg, Fe, Mn or Zn.
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Patent Agency Ranking
公开(公告)号：US20230249136A1
公开(公告)日：2023-08-10
申请号：US18009916
申请日：2021-06-09
Inventor： Linfeng LEI , Arne LINDBRÅTHEN , Xuezhong HE
IPC: B01D71/02 , D01F2/02 , D01D5/24 , D01F9/16 , D01D5/06 , B01D53/22 , B01D69/02 , B01D69/08 , B01D67/00
CPC classification number: B01D71/021 , D01F2/02 , D01D5/24 , D01F9/16 , D01D5/06 , B01D53/228 , B01D69/02 , B01D69/08 , B01D67/0067 , D10B2201/22 , D10B2505/04 , B01D2053/224 , B01D2323/081 , B01D2325/0231 , B01D2325/0233 , B01D2325/20 , B01D2256/16 , B01D2257/504
Abstract: The present invention relates to a process for the production of asymmetric cellulose hollow fibres and the use of such fibres in the production of asymmetric carbon hollow fibre membranes (CHFMs). In particular, the present invention provides a facile and scalable process for the preparation of asymmetric CHFMs by direct pyrolysis of polymeric precursors without the need for complex pre-pyrolysis treatment steps to prevent pore collapse. The present invention also relates to the use of asymmetric CHFMs prepared according to said process in the separation of hydrogen gas from a mixed gas source, especially in the separation of hydrogen from CO2 in the steam-methane reforming reaction.
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公开(公告)号：US11450528B2
公开(公告)日：2022-09-20
申请号：US16456591
申请日：2019-06-28
Inventor： Dong Chul Kim , Ida Marie Høiaas , Mazid Munshi , Bjørn Ove Fimland , Helge Weman , Dingding Ren , Dasa Dheeraj
IPC: H01L21/02
Abstract: A process for growing nanowires or nanopyramids comprising: (I) providing a graphitic substrate and depositing AlGaN, InGaN, AlN or AlGa(In)N on said graphitic substrate at an elevated temperature to form a buffer layer or nanoscale nucleation islands of said compounds; (II) growing a plurality of semiconducting group III-V nanowires or nanopyramids, preferably III-nitride nanowires or nanopyramids, on the said buffer layer or nucleation islands on the graphitic substrate, preferably via MOVPE or MBE.
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公开(公告)号：US20220262978A1
公开(公告)日：2022-08-18
申请号：US17627290
申请日：2020-07-16
Inventor： Mazid MUNSHI , Helge WEMAN , Dasa L. DHEERAJ , Bjorn-Ove M. FIMLAND , Leidulv VIGEN , David BARRIET
IPC: H01L33/08 , H01L31/0304 , H01L31/0352 , H01L31/0392 , H01L31/18 , H01L33/00 , H01L33/06 , H01L33/12 , H01L33/24 , H01L33/32
Abstract: A composition of matter comprising: a graphene layer carried directly on a sapphire, Si, SiC, Ga2O3 or group III-V semiconductor substrate; wherein a plurality of holes are present through said graphene layer; and wherein a plurality of nanowires or nanopyramids are grown from said substrate in said holes, said nanowires or nanopyramids comprising at least one semiconducting group III-V compound.
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公开(公告)号：US20220151586A1
公开(公告)日：2022-05-19
申请号：US16967813
申请日：2019-02-07
Inventor： Hans Torp , Siri Ann Nyrnes , Sigrid Dannheim Vik , Ragnhild Støen
Abstract: The invention provides a method for monitoring or predicting the onset or progression of a disease or pathological condition and/or a response to treatment in an infant vertebrate animal subject, wherein said method uses unfocused ultrasound pulses to determine a characteristic of blood flow within the brain of the subject and said characteristic or the profile of said characteristic over time is indicative or predictive of the disease or pathological condition or response to treatment, or variation in said characteristic or the profile of said characteristic over time is indicative or predictive of the disease or pathological condition, or indicative or predictive of a change in the disease or pathological condition or response to treatment.
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公开(公告)号：US11246907B2
公开(公告)日：2022-02-15
申请号：US16683188
申请日：2019-11-13
Inventor： Marit Otterlei
Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein the agent comprises:
(i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein:
X1 is a basic amino acid;
X2 is an aromatic amino acid;
X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P);
X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and
X5 is a basic amino acid or Proline (P); or
(ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i).
In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.
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