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21.发明申请FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET 有权鳄梨和针头复合物（注射成型）作为抗真菌药物目标公开(公告)号：US20160002239A1
公开(公告)日：2016-01-07
申请号：US14770708
申请日：2014-02-27
Inventor： Fadel Alexis SAMATEY , Vladimir A MESHCHERYAKOV , Hideyuki MATSUNAMI , Akio KITAO
IPC: C07D473/08 , C07D239/49 , C12Q1/02
CPC classification number: C07D473/08 , A61K31/505 , A61K31/522 , C07D239/49 , C12Q1/025 , C12Q1/18 , G01N2333/255 , G01N2500/04 , Y02A50/406 , Y02A50/473 , Y02A50/475
Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
Abstract translation: 本发明涉及一种使用针型III分泌系统筛选通过强毒细菌分泌毒素至宿主细胞质的化合物的方法。 通过筛选与来自鼠伤寒沙门氏菌或其旁系同源物的膜蛋白FlhB的细胞质结构域的环区相互作用的化合物来选择本发明的化合物。 还提供了包括本发明化合物的组合物，该化合物的用途和治疗由毒性细菌引起的疾病的方法。
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公开(公告)号：US20240352310A1
公开(公告)日：2024-10-24
申请号：US18688184
申请日：2022-08-29
Inventor： Ayumu KARIMATA , Julia KHUSNUTDINOVA
CPC classification number: C09K11/06 , C09K11/02 , C09K2211/1011
Abstract: Triboluminescent materials that produce light emission in response to mechanical action attract significant interest due to their wide range of potential utilization for mechanoresponsive sensors, light emitting devices and stimuli-induced glowing fibers, dyes, particles, paste, and films, etc. Here, we would like to disclose a general method of generating triboluminescent polymer materials blended with wide range of luminophores that emit light in response to mechanical action emitting light in a wide range of spectrum. The light generation is achieved via a non-destructive method even in the absence of direct contact with the polymer (e.g. through the layer of another polymer). Biocompatible luminophores can be easily utilized. Light emission is also observed under dry air.
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公开(公告)号：US12116383B2
公开(公告)日：2024-10-15
申请号：US17841241
申请日：2022-06-15
Inventor： Fujie Tanaka , Sherida Johnson
Abstract: The present invention provides a novel process for preparing an oligosaccharide C-glycoside derivative of formula I, comprising reacting a compound of formula II with compound of formula III in the presence of at least one primary or secondary amine and at least one additive [in the formulae, the substituents are as defined herein], and novel oligosaccharide C-glycoside derivatives that can be prepared using the process.
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公开(公告)号：US11867597B2
公开(公告)日：2024-01-09
申请号：US17677298
申请日：2022-02-22
Inventor： Nikhil Bhalla , Amy Shen Fried , Kang-Yu Chu
IPC: G01N21/75 , G01N33/543 , C03C17/09 , G01N21/552 , G01N21/41
CPC classification number: G01N33/54373 , C03C17/09 , G01N21/554 , C03C2217/255 , C03C2218/151 , C03C2218/33 , G01N21/41
Abstract: A method for making a plasmonic mushroom array includes: forming a plurality of metal nano-islands each having nanometer-range dimensions on a surface of a glass substrate; and subjecting to the glass substrate having the plurality of metal nano-islands formed thereon to reactive ion etching such that the plurality of metal nano-islands are converted to a plurality of mushroom-shaped structures each having a metal cap supported by a pillar made of a material of the glass substrate and each having dimensions smaller than the dimensions of the nano-islands, the plurality of mushroom-shaped structures being arranged in a substantially regular pattern with intervals smaller than average intervals between the nano-islands, thereby forming the plurality of nano-scale mushroom-shaped structures on the glass substrate that can exhibit localized surface plasmon resonance.
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25.发明公开公开(公告)号：US20230231118A1
公开(公告)日：2023-07-20
申请号：US18011357
申请日：2021-09-07
Inventor： Panagiotis GRAMMATIKOPOULOS , Marta HARO , Junlei ZHAO , Emilio Jose JUAREZ-PEREZ
IPC: H01M4/38 , H01M4/134 , H01M4/04 , H01M4/1395
CPC classification number: H01M4/386 , H01M4/134 , H01M4/0471 , H01M4/1395 , H01M4/0423 , H01M2004/027
Abstract: A composite nanoarchitecture unit is disclosed. The unit comprises a columnar film grown on top of another layer where the columns touch each other at the top forming arches having optimized characteristics. This nanoarchitecture unit, called nano-vault, achieves high mechanical stability for films under strong and variable stress action.
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Patent Agency Ranking
公开(公告)号：US11677206B2
公开(公告)日：2023-06-13
申请号：US16806874
申请日：2020-03-02
Inventor： Yuimaru Kubo , Jason Robert Ball , Petr Moroshkin , Denis Konstantinov
IPC: H01S1/02
CPC classification number: H01S1/02
Abstract: Embodiments of the microwave amplification system are described. In an embodiment, a microwave amplification system includes a microwave amplifier that contains a paramagnetic material with an impurity. The impurity has a plurality of nuclear spin and electron spin-based energy levels. The system includes an input to receive a pumping signal which is transmitted to the microwave amplifier to cause a population inversion in the impurity and excite it to one of the nuclear spin and electron spin-based energy levels. The system further includes another input to receive an input signal to be amplified by the microwave amplifier, the input signal having a lower power than the pumping signal. Once transmitted to the microwave amplifier, the input signal is amplified by the excited state of the impurity in the microwave amplifier thereby generating an amplified signal.
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公开(公告)号：US11645574B2
公开(公告)日：2023-05-09
申请号：US16130482
申请日：2018-09-13
Inventor： Tomotake Sasaki , Eiji Uchibe , Kenji Doya , Hirokazu Anai , Hitoshi Yanami , Hidenao Iwane
CPC classification number: G06N20/00 , G06N3/006 , H04L41/0816 , H04L41/16 , H04L43/08
Abstract: A non-transitory, computer-readable recording medium stores therein a reinforcement learning program that uses a value function and causes a computer to execute a process comprising: estimating first coefficients of the value function represented in a quadratic form of inputs at times in the past than a present time and outputs at the present time and the times in the past, the first coefficients being estimated based on inputs at the times in the past, the outputs at the present time and the times in the past, and costs or rewards that corresponds to the inputs at the times in the past; and determining second coefficients that defines a control law, based on the value function that uses the estimated first coefficients and determining input values at times after estimation of the first coefficients.
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公开(公告)号：US20210291159A1
公开(公告)日：2021-09-23
申请号：US16614836
申请日：2018-05-18
Inventor： Kazumi Toda-Peters , Amy Shen Fried , Shivani Sathish , Doojin Lee , Casey James Galvin , Kei Funakoshi
Abstract: An integrated system for sampling and processing a liquid suspension, the system comprising: a cartridge member comprising a sampling port on a first end of the cartridge member, a second one-way valve in communication with the sampling port, a stopper at a second end of the cartridge member, and a fluid chamber between the second one-way valve and the stopper; a body member having a first end configured to accept the first end of the cartridge member and a second end opposite the first end of the body member; and a cap unit disposed on the second end of the body member, the cap unit comprising a wash chamber, wherein the cap unit comprises a first one-way valve between the second end of the body member and the wash chamber and a filter between the first one-way valve and the wash chamber or a filter between the second end of the body member and the wash chamber and a first one-way valve between the filter and the wash chamber.
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公开(公告)号：US20210276954A1
公开(公告)日：2021-09-09
申请号：US17212514
申请日：2021-03-25
Inventor： Fujie TANAKA , Feng YIN
IPC: C07D209/54 , C07C201/12 , C07C205/51 , C07D207/16
Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.
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公开(公告)号：US10995119B2
公开(公告)日：2021-05-04
申请号：US16067764
申请日：2017-01-06
Inventor： Toshifumi Akizawa , Tadashi Yamamoto
Abstract: The present invention provides a novel molecule that catalyzes a hydrolysis reaction and is different from enzyme proteins. The catalytic peptide according to the present invention is a catalytic peptide that catalyzes a hydrolysis reaction, including at least one peptide selected from the group consisting of the following peptides (A1) to (A4): (A1) a peptide consisting of Box A and at least one of an upstream region and a downstream region therefrom in a Tob/BTG protein; (A2) a peptide consisting of a partial region of the peptide (A1); (A3) a peptide that consists of an amino acid sequence obtained by deletion, substitution, addition, and/or insertion of one or more amino acids in an amino acid sequence of the peptide (A1) or (A2) and has hydrolysis activity; and (A4) a peptide consisting of an amino acid sequence with a sequence identity of at least 85% to the amino acid sequence of the peptide (A1) or (A2) and having hydrolysis activity.
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