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公开(公告)号：US10881447B2
公开(公告)日：2021-01-05
申请号：US15827875
申请日：2017-11-30
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl Schoenbach , Richard Heller
Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
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公开(公告)号：US10786303B2
公开(公告)日：2020-09-29
申请号：US15885930
申请日：2018-02-01
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US10363093B2
公开(公告)日：2019-07-30
申请号：US15169154
申请日：2016-05-31
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
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公开(公告)号：US20190054294A1
公开(公告)日：2019-02-21
申请号：US16104089
申请日：2018-08-16
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. PAKHOMOV , Olga N. PAKHOMOVA , Shu XIAO
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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公开(公告)号：US20180296837A1
公开(公告)日：2018-10-18
申请号：US16014822
申请日：2018-06-21
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Shu XIAO , Andrei PAKHOMOV , Karl H. SCHOENBACH
CPC classification number: A61N1/36014 , A61N1/40 , A61N2/006 , A61N5/02
Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
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Patent Agency Ranking
公开(公告)号：US20180154142A1
公开(公告)日：2018-06-07
申请号：US15831845
申请日：2017-12-05
Applicant: Old Dominion University Research Foundation
Inventor： Siqi Guo , Stephen J. Beebe , Richard Heller
CPC classification number: A61N1/36002 , A61B18/1206 , A61B18/1477 , A61B2018/00291 , A61B2018/00333 , A61B2018/00577 , A61B2018/00613 , A61B2018/00636 , A61K45/00 , A61N1/05 , A61N1/326 , A61P35/00
Abstract: Disclosed herein are methods and devices for stimulating an immune response to a disease in a subject, which involves passing sub-microsecond long pulses of electric fields having an amplitude between 5 kV/cm and 68 kV/cm through an abnormal growth of a subject sufficient to suppress myeloid-derived suppressor cell (MDSC) or regulatory T cell (Treg) production, increase adenosine triphosphate (ATP) or high mobility group box 1 (HMGB1) production, or stimulate dendritic cell activation in the subject.
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公开(公告)号：US20170319843A1
公开(公告)日：2017-11-09
申请号：US15654625
申请日：2017-07-19
Inventor： Stephen J. BEEBE , Karl H. SCHOENBACH
Abstract: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
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公开(公告)号：US20160106335A1
公开(公告)日：2016-04-21
申请号：US14885023
申请日：2015-10-16
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl H. Schoenbach , Shu Xiao
IPC: A61B5/05
CPC classification number: A61B5/0507 , A61B5/05 , A61B6/03 , A61B2576/00
Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
Abstract translation: 提供成像和记录系统。 该系统包括用于照射生物组织的大功率聚焦天线。 该系统还包括用于为天线供电的电源。 该系统还包括数据采集模块，用于记录由大功率聚焦天线照射的组织的介电特性。 系统使用超短电脉冲照射组织。
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公开(公告)号：US20150201991A1
公开(公告)日：2015-07-23
申请号：US14604400
申请日：2015-01-23
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
CPC classification number: A61B18/1492 , A61B18/1477 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00613
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
Abstract translation: 公开了一种用于进行心肌组织消融的装置和方法。 该装置包括施加纳秒脉冲电场的多个消融电极配置。 所述方法涉及治疗心律失常的治疗方法，例如心房颤动和瘢痕相关室性心动过速等。 受影响的心肌组织被消融，产生通过施加到穿透电极，内端电极或内表面电极的纳秒脉冲电场使能的多个损伤。 进行不同的电生理测试以评估纳秒脉冲电场消融在心脏内特定的所需组织位置的应用。 测试结果显示了克服当前消融治疗的局限性的潜力，从而为患者和医生提供了心律失常治疗的优势。
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公开(公告)号：US08649631B2
公开(公告)日：2014-02-11
申请号：US13758849
申请日：2013-02-04
Applicant: Old Dominion University Research Foundation
Inventor： Mohammed Nazrul Islam , K. Vijayan Asari , Mohammad A. Karim
CPC classification number: G06K9/6256 , G06K9/209 , G06K9/746 , G06K9/748
Abstract: Disclosed is a distortion invariant system, method and computer readable medium for detecting the presence of one or more predefined targets in an input image. The input image and a synthetic discriminant function (SDF) reference image are correlated in a shift phase-encoded fringe-adjusted joint transform correlation (SPFJTC) correlator yielding a correlation output. A peak-to-clutter ratio (PCR) is determined for the correlation output and compared to a threshold value. A predefined target is present in the input image when the PCR is greater than or equal to the threshold value.
Abstract translation: 公开了一种用于检测输入图像中一个或多个预定义目标的存在的失真不变系统，方法和计算机可读介质。 输入图像和合成判别函数（SDF）参考图像在产生相关输出的相移编码条纹调整关联变换相关（SPFJTC）相关器中相关。 确定相关输出的峰 - 杂波比（PCR），并将其与阈值进行比较。 当PCR大于或等于阈值时，输入图像中存在预定义的目标。
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