公开(公告)号：US20240091300A1

公开(公告)日：2024-03-21

申请号：US18506582

申请日：2023-11-10

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Gong CHEN ,  Gang-Yi WU ,  Lei ZHANG ,  Jiu-Chao YIN ,  Hana YEH ,  Ning-Xin MA ,  Grace LEE

IPC: A61K38/05 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  C12N5/0793

CPC classification number: A61K38/05 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  C12N5/0619 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/08

Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

公开(公告)号：US11897479B2

公开(公告)日：2024-02-13

申请号：US17441787

申请日：2020-03-26

Applicant: The Penn State Research Foundation

Inventor： Craig E. Beal ,  Sean N. Brennan

IPC: B60W40/068 ,  B60W40/101 ,  B60W40/13

CPC classification number: B60W40/068 ,  B60W40/101 ,  B60W40/13 ,  B60W2040/1384 ,  B60W2420/10 ,  B60W2510/202 ,  B60W2520/28 ,  B60W2540/18 ,  B60W2552/40

Abstract: A device for estimating a friction coefficient between a road surface and an automotive tire through determination of a steering torque during a steering maneuver of a slow-rolling or stationary vehicle includes a computer configured for constructing a brush model for a description of the steering torque across a contact patch between the tire and road surface. The steering torque is a torque acting on a steering axis required to overcome resistance to tire twisting on the road surface at a wheel velocity and a steering rate. The steering torque depends on a tire brush vertical load distribution and relative motion of tire brushes and the road surface. The device further includes sensors for measuring the wheel velocity and the steering rate and mechanism for measurements or estimation of the steering torque. The friction coefficient is estimated based on the measurements or estimation of the steering torque and the brush model.

公开(公告)号：US20240025886A1

公开(公告)日：2024-01-25

申请号：US18037751

申请日：2021-11-18

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  THE PENN STATE RESEARCH FOUNDATION

Inventor： Vladimir SPIEGELMAN ,  Vikash SINGH ,  Arun SHARMA ,  Amandeep SINGH ,  Joel YISRAELI ,  Nadav WALLIS ,  Froma OBERMAN

IPC: C07D405/14 ,  C07D413/14 ,  C07D405/12 ,  C07D403/10 ,  C07D405/10 ,  A61P35/00

CPC classification number: C07D405/14 ,  C07D413/14 ,  C07D405/12 ,  C07D403/10 ,  C07D405/10 ,  A61P35/00

Abstract: The present invention is directed to compounds and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a disorder associated with binding of IGF2BP1 to an RNA in a subject in need thereof are also provided.

公开(公告)号：US20240024216A1

公开(公告)日：2024-01-25

申请号：US18270914

申请日：2022-01-05

Applicant: The Penn State Research Foundation

Inventor： John Elfar ,  Jagadeeshaprasad Mashanipalya Guddadarangaiah ,  Prem Kumar Govindappa

IPC: A61K8/49 ,  A61K31/4409 ,  A61Q7/00

CPC classification number: A61K8/4926 ,  A61K31/4409 ,  A61Q7/00

Abstract: This document provides methods and materials for treating hair loss. For example, compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP can be administered to a mammal having hair loss to treat the hair loss (e.g., to promote hair growth). Further more, a method for increasing hair regeneration, wherein said method comprises administering a composition comprising 4-AP or one or more derivatives of 4-AP to a mammal identified as being in need of increased hair regeneration.

公开(公告)号：US20230404989A1

公开(公告)日：2023-12-21

申请号：US18036837

申请日：2021-11-12

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Fadia KAMAL

IPC: A61K31/4525 ,  A61K38/29 ,  A61P19/02

CPC classification number: A61K31/4525 ,  A61K38/29 ,  A61P19/02

Abstract: The present disclosure is directed to compositions and methods for the treatment of inflammation, particularly methods using compositions containing paroxetine or a pharmaceutically acceptable salt or derivative thereof.

公开(公告)号：US20230357869A1

公开(公告)日：2023-11-09

申请号：US18311427

申请日：2023-05-03

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： YINONG YANG ,  MATTHEW S. WHEATLEY ,  QIN WANG

IPC: C12Q1/6895 ,  C12N15/11 ,  C12N9/22

CPC classification number: C12Q1/6895 ,  C12N15/11 ,  C12N9/22 ,  C12N2310/20

Abstract: The embodiments disclosed herein utilize type V CRISPR/Cas effector proteins to provide robust diagnostic assays with attomolar sensitivity. Embodiments disclosed herein can detect DNA targets from bacterial plant pathogens and can differentiate targets from non-targets based on single base pair differences. Such embodiments are useful in multiple scenarios involving bacterial plant pathogens such as Candidatus Liberibacter asiaticus and Candidatus Phytoplasma trifolii responsible for citrus greening and potato purple top, respectively.

公开(公告)号：US11761919B2

公开(公告)日：2023-09-19

申请号：US16510742

申请日：2019-07-12

Applicant: University of Utah Research Foundation ,  The Penn State Research Foundation

Inventor： Benjamin R. Bunes ,  Leonard Cardillo ,  Douglas Later ,  Ling Zang ,  Douglas H. Werner ,  Ronald Jenkins ,  Micah D. Gregory

IPC: G01N27/12 ,  G01R23/02 ,  C07D471/06 ,  G01N33/00

CPC classification number: G01N27/122 ,  C07D471/06 ,  G01N27/127 ,  G01N33/0057 ,  G01R23/02

Abstract: A system for low power chemical sensing can include a voltage shift unit which receives a voltage signal from a chemical sensor unit. The voltage signal can be determined by a concentration of an analyte. The voltage shift unit can transform the voltage signal to an input voltage signal, and send the input voltage signal to a plurality of frequency selective surface (FSS) units of an FSS array. The FSS array can communicate a radio frequency (RF) signal in an Institute of Electrical and Electronics Engineers (IEEE) S band with a resonant frequency based on the input voltage to provide the concentration of the analyte.

公开(公告)号：US20230272348A1

公开(公告)日：2023-08-31

申请号：US18012024

申请日：2021-06-22

Applicant: The Penn State Research Foundation

Inventor： Xiaojun Lian ,  Lauren Nicole Randolph ,  Yuqian Jiang

IPC: C12N5/071 ,  C12N15/90

CPC classification number: C12N5/0692 ,  C12N15/907 ,  C12N2506/45 ,  C12N2501/727 ,  C12N2501/165

Abstract: The present invention relates to a method of producing an enriched preparation of hemogenic endothelial progenitor cells. This method involves providing a population of pluripotent stem cells and inducing expression of a SOXF transcription factor in the pluripotent stem cells of the population. The method further involves culturing the population of pluripotent stem cells expressing the SOXF transcription factor, whereby the enriched preparation of hemogenic endothelial progenitor cells is produced as a result of said culturing. The present invention also relates to a method of producing an enriched preparation of hematopoietic progenitor cells and methods of treating a subject having a condition mediated by a loss or dysfunction of hematopoietic stem cells or by a loss of immune cells.

公开(公告)号：US11739164B2

公开(公告)日：2023-08-29

申请号：US16463158

申请日：2017-12-14

Applicant: The Penn State Research Foundation

Inventor： Melik Demirel ,  Mert Vural ,  Mauricio Terrones ,  Yu Lei ,  Ibrahim Tarik Ozbolat

IPC: C07K17/14 ,  B41M5/00 ,  C07K1/04 ,  B82Y15/00 ,  B82Y40/00

CPC classification number: C07K17/14 ,  B41M5/0011 ,  C07K1/042 ,  B82Y15/00 ,  B82Y40/00 ,  Y10S977/705 ,  Y10S977/712 ,  Y10S977/725 ,  Y10S977/727 ,  Y10S977/828

Abstract: Provided are compositions that include at least one two-dimensional layer of an inorganic compound and at least one layer of an organic compound in the form of one or more polypeptides. Methods of making and using the materials are provided. The organic layer contains one or more polypeptides, each of which have alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more beta-sheets. The amorphous subsequences form a network of hydrogen bonds. A method includes i) combining one or more polypeptides with an inorganic material and an organic solvent, and ii) depositing one or more polypeptides, the inorganic material and the organic solvent onto a substrate. These steps can be repeated to provide a composite material that is a multilayer composite material. The composite materials can be used in a wide array of textile, electronic, semi-conducting, and other applications.

公开(公告)号：US20230236016A1

公开(公告)日：2023-07-27

申请号：US18011996

申请日：2021-07-20

Applicant: The Penn State Research Foundation

Inventor： Nelson Daniel Troncoso Aldas ,  Vijaykrishnan Narayanan

IPC: G01C21/20 ,  G06V20/50 ,  G06T7/73 ,  G06F3/01 ,  G06F3/16 ,  G06F3/04817 ,  G06F3/0484 ,  H04M1/72403

CPC classification number: G01C21/20 ,  G06V20/50 ,  G06T7/73 ,  G06F3/016 ,  G06F3/167 ,  G06F3/04817 ,  G06F3/0484 ,  H04M1/72403 ,  G06T2207/30244 ,  G06T2200/24 ,  G06T2207/20092

Abstract: A system, device, application stored on non-transitory memory, and method can be configured to help a user of a device locate and pick up objects around them. Embodiments can be configured to help vision-impaired users find, locate, and pickup objects near them. Embodiments can be configured so that such functionality is provided locally via a single device so the device is able to provide assistance and hand guidance without a connection to the internet, a network, or another device (e.g. a remote server, a cloud based server, a server connectable to the device via an application programming interface, API, etc.).