利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

60 条记录 (耗时 0.067 秒)

    BIOLOGICALLY ACTIVE POLYPEPTIDES DERIVED FROM A NOVEL EARLY STAGE PREGNANCY FACTOR DESIGNATED MATERNIN (MA)
    22.
    发明申请
    BIOLOGICALLY ACTIVE POLYPEPTIDES DERIVED FROM A NOVEL EARLY STAGE PREGNANCY FACTOR DESIGNATED MATERNIN (MA) 审中-公开
    从一个新的早期阶段产生的生物活性多肽被指定的MATERNIN（MA）

    公开(公告)号：US20120083587A1

    公开(公告)日：2012-04-05

    申请号：US13159285

    申请日：2011-06-13

    申请人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    发明人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    IPC分类号： C07K16/18 ,  C07K16/42 ,  C12N1/21 ,  C12N5/16 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K48/00 ,  C07K14/59 ,  C07K2319/00

    摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.

    摘要翻译： 本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。 治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。 治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。 本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。

    Method for promoting hematopoiesis
    28.
    发明授权
    Method for promoting hematopoiesis 失效
    促进造血的方法

    公开(公告)号：US06596688B1

    公开(公告)日：2003-07-22

    申请号：US09675776

    申请日：2000-09-29

    申请人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    发明人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    IPC分类号： A01N3718

    CPC分类号： C07K14/59

    摘要： The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods of promoting hematopoiesis, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or perparations of human chorionic gonadotropin, such as fractions of humna early pregnancy urine, which fractions have pro-hematopoietic activity. The present invention further relates to pharmaceutical compositions for promoting hematopoiesis.

    摘要翻译： 本发明涉及人绒毛膜促性腺激素β链的一个或多个部分的肽以及使用人绒毛膜促性腺激素促进造血的方法，其使用人绒毛膜促性腺激素的β链，含有一个或多个 人绒毛膜促性腺激素的β-链的部分及其衍生物和类似物。 本发明进一步涉及人绒毛膜促性腺激素的来源和/或起始部分，例如妊娠期尿液的部分，这些部分具有促造血活性。 本发明还涉及用于促进造血作用的药物组合物。

    Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
    29.
    发明授权
    Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin 失效
    通过施用人绒毛膜促性腺激素衍生物治疗和预防HIV感染

    公开(公告)号：US06319504B1

    公开(公告)日：2001-11-20

    申请号：US08709948

    申请日：1996-09-09

    申请人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    发明人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    IPC分类号： A61K3900

    CPC分类号： C07K14/59 ,  A61K38/00 ,  Y10S435/974

    摘要： The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.

    摘要翻译： 本发明涉及β-hCG，特别是具有41-54,45-54,47-53,45-57和45-58位氨基酸序列的β-hCG蛋白及其类似物和衍生物。 本发明还涉及通过施用本发明的治疗化合物治疗和预防HIV感染的方法。 这些治疗化合物包括hCG，β-hCG和β-hCG肽，hCG，β-hCG和β-hCG肽的类似物和衍生物，以及编码hCG，β-hCG和β-hCG肽的核酸。 在优选的实施方案中，将Aβ-hCG肽，特别是氨基酸47-53,45-57或45-58的β-hCG肽施用于受试者，以治疗或预防该受试者的HIV感染。 本发明还提供了用于筛选用于治疗或预防HIV感染的活性的hCG制剂的方法。 还提供药物组合物和治疗剂的施用方法。