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公开(公告)号：US09309574B1
公开(公告)日：2016-04-12
申请号：US08385231
申请日：1995-02-08
申请人： Robert C. Gallo , Flossie Wong-Staal , Mikulas Popovic , Beatrice H. Hahn , George M. Shaw , Amanda G. Fisher
发明人： Robert C. Gallo , Flossie Wong-Staal , Mikulas Popovic , Beatrice H. Hahn , George M. Shaw , Amanda G. Fisher
CPC分类号： C12Q1/703 , C12N15/63 , C12Q1/6834 , C12Q1/6876
摘要： Disclosed is the molecular cloning of HTLV-III, the adult leukemia and acquired immune deficiency syndrome (AIDS) virus. Clone BH10 contains a 9.0 Kb viral insert constituting the entire HTLV-III genome. Clones BH8 and BH5 contain viral inserts of 5.5 Kb and 3.5 Kb, respectively. These clones are suitable for the development of diagnostic and therapeutic measures for AIDS, as well as use as probes for the detection of AIDS. By scientific convention, HTLV-III, referred to herein also as HIV, has been renamed as HIV-1.
摘要翻译： 公开了HTLV-III的分子克隆，成人白血病和获得性免疫缺陷综合征（AIDS）病毒。 克隆BH10含有构成整个HTLV-III基因组的9.0Kb病毒插入物。 克隆BH8和BH5分别含有5.5Kb和3.5Kb的病毒插入物。 这些克隆适合于开发艾滋病的诊断和治疗措施，以及用作艾滋病检测的探针。 根据科学惯例，HTLV-III在本文中也称为HIV，已被更名为HIV-1。
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2.发明授权Acquired immune deficiency syndrome (AIDS) viral envelope protein and method of testing for AIDS 失效获得性免疫缺陷综合征（AIDS）病毒包膜蛋白和艾滋病检测方法
公开(公告)号：US6077935A
公开(公告)日：2000-06-20
申请号：US811896
申请日：1991-12-20
IPC分类号： G01N33/569 , A61K38/00 , A61K39/21 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/16 , C07K14/705 , C07K16/00 , C12N1/20 , C12N15/09 , C12P21/00 , C12P21/02 , C12Q1/70 , C12R1/125 , C12R1/19 , G01N33/577 , C07K1/00 , C07K17/00
CPC分类号： C07K14/005 , C12Q1/703 , A61K38/00 , C12N2740/16122
摘要： An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
摘要翻译： 公开了获得性免疫缺陷综合征（AIDS）病原体的包膜蛋白及其制备方法。 将工程化后的病毒DNA转移到宿主细胞中，生成包膜蛋白的表达载体。 公开了一种使用AIDS包膜蛋白测试人血液中存在抗艾滋病病毒抗体的方法。
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3.发明授权
公开(公告)号：US5869233A
公开(公告)日：1999-02-09
申请号：US456352
申请日：1995-06-01
CPC分类号： C07K14/005 , C12Q1/703 , A61K38/00 , C12N2740/16122 , Y10S435/975
摘要： An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
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4.发明授权
公开(公告)号：US5773210A
公开(公告)日：1998-06-30
申请号：US132406
申请日：1993-10-06
CPC分类号： C07K14/005 , C12Q1/703 , A61K38/00 , C12N2740/16122 , Y10S435/975
摘要： An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human blood for the presence of antibodies to the AIDS virus using the AIDS envelope protein is disclosed.
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公开(公告)号：US07815916B1
公开(公告)日：2010-10-19
申请号：US08464316
申请日：1995-06-05
CPC分类号： C12Q1/702 , A61K38/00 , C07K14/005 , C07K16/1054 , C07K16/1063 , C07K2319/00 , C12N2740/14022 , C12N2740/16122 , C12Q1/703
摘要： The determination of the nucleotide sequence of HTLV-III DNA; identification, isolation and expression of HTLV-III sequences which encode immunoreactive polypeptides by recombinant DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HTLV-III.
摘要翻译： 测定HTLV-III DNA的核苷酸序列; 公开了通过重组DNA方法编码免疫反应性多肽的HTLV-III序列的鉴定，分离和表达以及病毒RNA的产生。 这些多肽可用于免疫测定以检测HTLV-III。
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公开(公告)号：US6018027A
公开(公告)日：2000-01-25
申请号：US854
申请日：1997-12-30
申请人： Syed Zaki Salahuddin , Dharam V Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
发明人： Syed Zaki Salahuddin , Dharam V Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
IPC分类号： C07K14/03 , C12N7/00 , C12N7/02 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , C12N7/00 , C12Q1/701 , C12Q1/702 , C12Q1/703 , C12Q1/705 , G01N33/56983 , C12N2710/16521 , C12N2710/16522 , C12N2710/16551 , C12N2710/16622
摘要： A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
摘要翻译： 已经分离出新的人B淋巴细胞病毒，也被称为人疱疹病毒-6。 已经制备了DNA，分子克隆，抗原性病毒蛋白和对新病毒具有特异性的抗体。 已描述了新病毒及其衍生产品的各种用途。
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7.再颁专利公开(公告)号：USRE38824E1
公开(公告)日：2005-10-11
申请号：US10087882
申请日：2002-03-01
申请人： Syed Z. Salahuddin , Dharam V. Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
发明人： Syed Z. Salahuddin , Dharam V. Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
CPC分类号： C07K14/005 , C12N7/00 , C12N2710/16521 , C12N2710/16522 , C12N2710/16551
摘要： A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
摘要翻译： 已经分离出新的人B淋巴细胞病毒，也被称为人疱疹病毒-6。 已经制备了DNA，分子克隆，抗原性病毒蛋白和对新病毒具有特异性的抗体。 已描述了新病毒及其衍生产品的各种用途。
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公开(公告)号：US6054283A
公开(公告)日：2000-04-25
申请号：US774118
申请日：1996-12-23
申请人： Syed Zaki Salahuddin , Dharam V. Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
发明人： Syed Zaki Salahuddin , Dharam V. Ablashi , Steven F. Josephs , Carl W. Saxinger , Flossie Wong-Staal , Robert C. Gallo
CPC分类号： C07K14/005 , C12N7/00 , C12Q1/701 , C12Q1/702 , C12Q1/703 , C12Q1/705 , G01N33/56983 , C12N2710/16521 , C12N2710/16522 , C12N2710/16551 , C12N2710/16622
摘要： A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
摘要翻译： 已经分离出新的人B淋巴细胞病毒，也被称为人疱疹病毒-6。 已经制备了DNA，分子克隆，抗原性病毒蛋白和对新病毒具有特异性的抗体。 已描述了新病毒及其衍生产品的各种用途。
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公开(公告)号：US09328391B1
公开(公告)日：2016-05-03
申请号：US06693866
申请日：1985-01-23
CPC分类号： C12Q1/703 , A61K38/00 , C07K14/005 , C07K16/1054 , C07K16/1063 , C07K2319/40 , C07K2319/61 , C07K2319/80 , C12N2740/14022 , C12N2740/16122 , C12N2740/16222 , C12Q1/6813
摘要： The determination of the nucleotide sequence of HIV-1 DNA; identification, isolation and expression of HIV-1 DNA sequences which encode immunoreactive polypeptides by recombinant DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HIV-1.
摘要翻译： HIV-1 DNA核苷酸序列的测定; 公开了通过重组DNA方法编码免疫反应性多肽的HIV-1 DNA序列的鉴定，分离和表达以及病毒RNA的产生。 这样的多肽可用于免疫测定以检测HIV-1。
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公开(公告)号：US06858712B1
公开(公告)日：2005-02-22
申请号：US08463209
申请日：1995-06-05
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12N5/24 , C12P21/08 , C12Q1/70 , C07H21/02 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/702 , A61K38/00 , C07K14/005 , C07K16/1054 , C07K16/1063 , C07K2319/00 , C12N2740/14022 , C12N2740/16122 , C12Q1/703
摘要： The determination of the nucleotide sequence of HTLV-III DNA; identification, isolation and expression of HTLV-III sequences which encode immunoreactive polypeptides by recombinant DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HTLV-III.
摘要翻译： 测定HTLV-III DNA的核苷酸序列; 公开了通过重组DNA方法编码免疫反应性多肽的HTLV-III序列的鉴定，分离和表达以及病毒RNA的产生。 这些多肽可用于免疫测定以检测HTLV-III。
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