Composition and method to alter lean body mass and bone properties in a subject
    26.
    发明授权
    Composition and method to alter lean body mass and bone properties in a subject 有权
    在主体中改变瘦体重和骨骼特性的组合物和方法

    公开(公告)号:US07338656B2

    公开(公告)日:2008-03-04

    申请号:US10281067

    申请日:2002-10-25

    IPC分类号: A61K48/00 A01N63/00

    摘要: A method for decreasing the body fat proportion, increasing lean body mass, increasing bone density, or improving the rate of bone healing, or all, of a subject. Embodiments of the invention include delivering a heterologous nucleic acid sequence encoding GHRH or functional biological equivalent thereof into the cells of the subject and allowing expression of the encoded gene to occur while the modified cells are within the subject.

    摘要翻译: 或减少身体脂肪比例,增加瘦体重,增加骨密度,或改善受试者骨骼愈合或全身的方法。 本发明的实施方案包括将编码GHRH或其功能生物等价物的异源核酸序列递送到受试者的细胞中,并且允许编码基因在修饰的细胞在受试者内时发生。

    Super-active porcine growth hormone releasing hormone analog
    28.
    发明授权
    Super-active porcine growth hormone releasing hormone analog 有权
    超活性猪生长激素释放激素类似物

    公开(公告)号:US06551996B1

    公开(公告)日:2003-04-22

    申请号:US09624268

    申请日:2000-07-24

    IPC分类号: C07K1460

    CPC分类号: C07K14/60 A61K38/00 A61K48/00

    摘要: Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence (SEQ ID NO:1). Also included is (1) a method of treating growth hormone-related deficiencies associated with the growth hormone pathway; (2) a method for treating growth hormone-related deficiencies associated with genetic disease; (3) a method to improve growth performance in an animal; (4) a method of treating an animal having a growth deficiency disease; (5) a method of increasing the efficiency of an animal used for food; and, (6) a method to enhance growth in an animal.

    摘要翻译: 可以利用具有序列(SEQ ID NO:1)的新型GHRH类似物利用重组蛋白质治疗来改善由于生长激素(GR),生长激素释放激素(GHRH)或遗传性疾病的缺陷导致的生长不足。 还包括(1)治疗与生长激素途径相关的生长激素相关缺陷的方法; (2)治疗与遗传性疾病相关的生长激素相关缺陷的方法; (3)改善动物生长性能的方法; (4)治疗具有生长缺陷病的动物的方法; (5)提高用于食物的动物的效率的方法; 和(6)增强动物生长的方法。

    Wide range proportional flow control valve
    30.
    发明授权
    Wide range proportional flow control valve 失效
    宽范围比例流量控制阀

    公开(公告)号:US6109591A

    公开(公告)日:2000-08-29

    申请号:US738016

    申请日:1996-10-25

    IPC分类号: F16K5/12 F16K1/52

    CPC分类号: F16K5/12

    摘要: A continuous flow type proportional flow control valve having a very wide controllable flow range and having a valve seat port design permitting a continuous, stable closed loop control to be achieved. The flow port design cooperates with a simple cylindrical flow passage of a movable valve element and provides the valve with a very wide flow control range and the ability to smoothly control the opening, modulation, and closing of the valve to eliminate undesirable hydraulic shock which is an undesirable characteristic of pulse operated flow control systems. The flow controlling seat has a flow controlling port therein that cooperates with the flow port of the closure to define an effective valve opening that is proportionally variable over a wide range of closure movement. The seat port is provided with an extremely narrow elongate slot section less than 1/50th of the maximum width of the aperture. The seat opening also defines a large final, generally circular orifice section having a radius comparable to the radius of the bore in the ball. Further, the seat opening is defined by a transition between the elongate narrow slot and final circular orifice section in the form of two diverging curves offering an exponential flow characteristic of the form K=N.sup.x.

    摘要翻译: 一种连续流量比例流量控制阀,具有非常宽的可控流量范围,并具有允许实现连续,稳定的闭环控制的阀座端口设计。 流动端口设计与可移动阀元件的简单的圆柱形流动通道协作,并为阀提供非常宽的流量控制范围,并且能够平稳地控制阀的打开,调节和关闭,以消除不期望的液压冲击, 脉冲操作流量控制系统的不良特征。 流量控制座具有其中的流动控制端口,其与封闭件的流动端口配合以限定有效的阀门开口,其在较宽的关闭运动范围内可成比例地变化。 座椅端口设置有小于+ E的非常窄的细长槽部分,其为孔的最大宽度的1/50 + EE th。 座椅开口还限定了具有与球中的孔的半径相当的半径的大的最终的,大致圆形的孔部分​​。 此外,阀座开口由细长窄槽和最终圆孔部分之间的过渡限定,其形式为两个发散曲线,其提供形式为K = Nx的指数流特性。