公开(公告)号：US20120232648A1

公开(公告)日：2012-09-13

申请号：US13441764

申请日：2012-04-06

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F2/16 ,  A61F2/14

CPC classification number: B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20120203160A1

公开(公告)日：2012-08-09

申请号：US13501599

申请日：2010-10-12

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F9/007

CPC classification number: A61F9/00781 ,  A61K9/0051 ,  A61L2400/16 ,  A61L2430/16 ,  C08L2201/12

Abstract: The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.

Abstract translation: 本发明提供适于驻留在施莱姆氏管中以减少眼睛眼内压的眼部植入物及其使用方法。 在一些实施例中，眼部植入物包括适于和构造成在Schlemm管中以弯曲体积延伸的细杆。 细杆包括多个波形段，使得足够数量的波形段延伸到小梁网的内壁和Schlemm管的外壁，从而保持施莱姆管的开放。

公开(公告)号：US20120116504A1

公开(公告)日：2012-05-10

申请号：US13257196

申请日：2010-03-16

Applicant: Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

Inventor： Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

IPC: A61F2/14

CPC classification number: A61F9/00772 ,  A61F9/0017 ,  A61F2210/0014 ,  A61L27/04 ,  A61L27/14 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  A61M25/00 ,  A61M25/01 ,  A61M25/04 ,  A61M31/002

Abstract: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.

Abstract translation: 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。

公开(公告)号：US20090248141A1

公开(公告)日：2009-10-01

申请号：US12295594

申请日：2007-03-30

Applicant: Robin Shandas ,  Christopher M. Yakacki ,  Kenneth Gall ,  Alex E. Eckstein ,  Michael Lyons ,  Devatha P. Nair

Inventor： Robin Shandas ,  Christopher M. Yakacki ,  Kenneth Gall ,  Alex E. Eckstein ,  Michael Lyons ,  Devatha P. Nair

IPC: A61F2/92 ,  A61M29/00 ,  A61M29/04 ,  B29C35/02

CPC classification number: A61B17/12022 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/12163 ,  A61B17/1219 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61F2/844 ,  A61F2/88 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61L31/048 ,  A61L31/14 ,  A61L2400/16 ,  C08L33/04

Abstract: Medical devices for in vivo medical applications are disclosed. The medical devices are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These medical devices may be used in surgical procedures and in both vascular and non-vascular applications. These SMP medical devices have a post-implantation memory shape that is substantially identical to or slightly larger than the insertion site to adapt to vessel growth or size changes. SMP medical devices may be formed as stents or occlusion devices (i.e., plugs) having a number of different structural features. The SMP medical devices may be formed from a first monomer and a second cross-linking monomer, wherein the weight percentages of the first and second monomers are selected by performing an iterative function to reach a predetermined glass transition temperature (Tg) and a predetermined rubbery modulus to optimize post-implantation memory shape properties of the devices.

Abstract translation: 公开了用于体内医疗应用的医疗装置。 医疗器械由能够在生理温度下呈现记忆形状的形状记忆聚合物（SMP）材料构成。 这些医疗装置可用于外科手术和血管和非血管应用。 这些SMP医疗装置具有植入后记忆形状，其基本上与插入位点相同或略大，以适应血管生长或尺寸变化。 SMP医疗装置可以形成为具有多个不同结构特征的支架或闭塞装置（即插头）。 SMP医疗装置可以由第一单体和第二交联单体形成，其中第一和第二单体的重量百分比通过执行迭代函数来选择以达到预定的玻璃化转变温度（Tg）和预定的橡胶状 模数以优化植入后记忆形状特性的器件。