Patent search ap:"SORBONNE UNIVERSITÉ" Page 3

21.

发明申请
USE OF A TRANSITION METAL SULPHIDE COMPOUND IN A POSITIVE ELECTRODE FOR SOLID STATE BATTERIES 有权

公开(公告)号：US20220376251A1

公开(公告)日：2022-11-24

申请号：US17765922

申请日：2020-10-01

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLÈGE DE FRANCE , SORBONNE UNIVERSITÉ

Inventor： Jean-Marie TARASCON , Florencia MARCHINI

IPC: H01M4/58 , H01M10/0525 , H01M4/505 , H01M4/525

Abstract: The present invention generally relates to the use of a transition metal sulphide compound in a positive electrode for solid state batteries, to a transition metal sulphide compound, to a device or a material incorporating said compound, such as a composite material, an electrode, an electrochemical energy storage cell or a device such as an all-solid-state battery. It further relates to a method to manufacture and/or to use such a compound, material or device and to a process to manufacture said compound, material and/or device.

22.

发明授权
Compounds for the prevention and treatment of glucose intolerance related conditions and obesity 有权

公开(公告)号：US11491117B2

公开(公告)日：2022-11-08

申请号：US16652947

申请日：2018-10-04

Applicant: SORBONNE UNIVERSITÉ , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS , KYOTO UNIVERSITY

Inventor： Dominique Gauguier , Fumihiko Matsuda , François Brial

IPC: A61K31/05 , A61P3/10 , A61K9/00

Abstract: The disclosure pertains to a compound of formula (I), one of its pharmaceutically acceptable salts, or a composition comprising thereof, for use in the prevention or treatment of glucose intolerance related conditions, insulin deficit related conditions, nonalcoholic fatty liver disease and/or obesity.

23.

发明申请
A METHOD FOR MEASURING THE SPEED OF SOUND IN LIVER WITH A MOVING PROBE AND ASSOCIATED METHODS AND DEVICES 有权

公开(公告)号：US20220346748A1

公开(公告)日：2022-11-03

申请号：US17763268

申请日：2020-09-25

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE PARIS , SORBONNE UNIVERSITÉ , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELES DE LA VILLE DE PARIS

Inventor： Mathieu PERNOT , Thomas DEFFIEUX , Mickael TANTER , Clément PAPADACCI

IPC: A61B8/08 , A61B8/00 , G16H50/20 , G16H20/10 , G01S15/89

Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

24.

发明申请
PNEUMATIC STRUCTURE AND ASSOCIATED PRODUCTION METHOD 有权

公开(公告)号：US20220341479A1

公开(公告)日：2022-10-27

申请号：US17262402

申请日：2019-07-22

Applicant: PARIS SCIENCES ET LETTRES - QUARTIER LATIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITÉ , UNIVERSITÉ DE PARIS

Inventor： Emmanuel SIEFERT , Benoît ROMAN , José BICO , Etienne REYSSAT

IPC: F16F9/04

Abstract: Pneumatic Structure and Associated Production Method
The structure (10) comprises an elastically deformable body (12) defining at least one network of internal cavities (14), each internal cavity (14) having a closed contour in at least one section of the internal cavity (14),
Each internal cavity (14) is able to be pressurized so as to make the elastically deformable body (12) pass from a rest configuration to at least one pressurized configuration,
In each pressurized configuration, the elastically deformable body (12) has a macroscopic metric that is distinct from its macroscopic metric in the rest position,
In each pressurized configuration, the radius of curvature of an outer surface of the elastically deformable body (12), considered regarding each internal cavity (14) adjacent to the outer surface, is greater than twice the size of the internal cavity (14) adjacent to the outer surface.

25.

发明授权
Selective organic cation transporters inhibitors for the treatment of depressive disorders 有权

公开(公告)号：US11414398B2

公开(公告)日：2022-08-16

申请号：US16630082

申请日：2018-07-13

Applicant: SORBONNE UNIVERSITÉ , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PARIS DESCARTES

Inventor： Sophie Gautron , Nicolas Pietrancosta , Francine Acher , Laetitia Chausset-Boissarie

IPC: C07D401/06

Abstract: Disclosed are organic cation transporters (OCTs) inhibitors of Formula (A), as well as their pharmaceutically acceptable tautomers, salts or solvates. Also disclosed are pharmaceutical compositions including such OCTs inhibitor of Formula (A) and their use for treating and/or preventing mood-related disorders such as depressive disorders.

26.

发明申请
EXPRESSION VECTOR FOR CHOLESTEROL 24-HYDROLASE IN THERAPY OF RETT SYNDROME 有权

公开(公告)号：US20220233654A1

公开(公告)日：2022-07-28

申请号：US17611966

申请日：2020-05-20

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , SORBONNE UNIVERSITÉ , ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIÈRE)

Inventor： Françoise PIGUET , Nathalie CARTIER-LACAVE

IPC: A61K38/46 , A61K48/00 , A61P25/28

Abstract: Rett syndrome (RTT) is a neurodevelopmental disorder that affects girls almost exclusively (about 1 in 10 000 females). It is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. Herein, the inventors demonstrated that delivering a vector expressing a cholesterol 24-hydroxylase (CYP46A1) gene intravenously in a mouse model of RTT is able to prevent/correct the development of motor impairment, in a mild and an aggravated model of the disease both in male and female mice. In addition in males, the inventors demonstrated a prevention of the loss of Purkinje cells and an improvement of astrogliosis and microgliosis in the mild KO MECP2 model. Thus, the present invention relates to a vector for use in the treatment of Rett syndrome or related autism spectrum disorder, which vector comprises cholesterol 24-hydroxylase encoding nucleic acid.

27.

发明申请
METHOD TO DIAGNOSE A CMMRD 有权

公开(公告)号：US20220136066A1

公开(公告)日：2022-05-05

申请号：US17434553

申请日：2020-03-05

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) , SORBONNE UNIVERSITÉ

Inventor： Alex DUVAL , Florence COULET , Erell GUILLERM , Olivier BUHARD

IPC: C12Q1/6886

Abstract: The present invention relates to the diagnostic of CMMRD. In the present work, the inventors aimed to develop a test that could drastically simplify and improve the diagnosis of CMMRD based on DNA sequence analysis of primary blood cells (PBCs) from patients. Using massive parallel sequencing, they explored the possibility that MSI, the main genomic and functional consequence of constitutive MMR-deficiency, was likely to occur in CMMRD PBCs well before any transformation. Thus the present invention relates to a method of diagnosing a CMMRD cancer or a MSI leukemia/lymphoma in a patient in need thereof.

28.

发明授权
Objective, camera and system adapted for optogenetics comprising such objective 有权

公开(公告)号：US11320649B2

公开(公告)日：2022-05-03

申请号：US16622987

申请日：2018-06-28

Applicant: GENSIGHT BIOLOGICS , Sorbonne Université , Centre National de la Recherche Scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Joël Chavas , Guillaume Chenegros , Charlie Galle

IPC: G02B3/00 , G02B27/00 , G02B3/14 , A61F2/16

Abstract: The present invention concerns an objective (10) for imaging an object field of view of 10° onto an imager (12), the objective (10) comprising in order of the propagating direction: —a first lens unit (U1) comprising several lenses, the first lens unit (U1) having a positive first focal length and a first dimension inferior to 15 millimeters, —a bending mirror (M) adapted to bend at a 90° angle, —a liquid lens (LL), and —a second lens unit (U2) comprising several lenses, the second lens unit (U2) having a positive second focal length and a second dimension, the ratio between the first focal length and the second focal length being comprised between 1.0 and 2.0 and the ratio between the first dimension and the second dimension being superior or equal to 2.