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21.发明申请公开(公告)号：US20200238047A1
公开(公告)日：2020-07-30
申请号：US16635953
申请日：2018-08-01
Inventor： Chang Mo HWANG , Young Hak KIM , Gi Byoung NAM , Jae Soon CHOI , Gi Seok JEONG , So Yeon JIN
Abstract: According to the present invention, it is possible to provide a catheter capable of measuring the magnitude and direction of an external force applied to the front end of the catheter with a precise sensitivity by using information regarding the amount of change in the amount of light received by the optical fiber inside the catheter body.
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公开(公告)号：US10683553B2
公开(公告)日：2020-06-16
申请号：US15742408
申请日：2016-07-06
Applicant: THE ASAN FOUNDATION
Inventor： Dong Hoon Jin , Seung Woo Hong , Jai Hee Moon , Jae Sik Shin , Seung Mi Kim , Dae Hee Lee , Eun Young Lee , Jung Shin Lee , Bong Choel Kim
IPC: C12Q1/68 , C12Q1/6886
Abstract: The present invention relates to a method for determining sensitivity to a simultaneous inhibitor against poly ADP ribose polymerase (PARP) and Tankyrase. According to the present invention, a colorectal treatment effect can be maximized by sorting patients having sensitivity to the simultaneous inhibitor against PARP and Tankyrase.
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公开(公告)号：US20200038063A1
公开(公告)日：2020-02-06
申请号：US16597046
申请日：2019-10-09
Inventor： Jae Soon CHOI , Young Jin MOON , Jong Woo CHOI , Woo Shik JEONG , Ho Yul LEE
Abstract: The present disclosure relates to an apparatus for closed reduction of a bone fracture. The apparatus includes at least: a pulling adaptor including: a handle configured to be gripped by an operator; an insertion rod that is extended from the handle in a longitudinal direction of the handle, and configured to be inserted into the bone fracture which is depressed in at least one area thereof; and a pulling lug that is bent and extended from an end of the insertion rod such that a longitudinal direction of the pulling lug is perpendicular to a longitudinal direction of the insertion rod or such that the pulling lug is inclined with respect to the insertion rod, the pulling lug being configured to be inserted into the at least one depressed area of the bone fracture, in order to pull the bone fracture.
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公开(公告)号：US20190281797A1
公开(公告)日：2019-09-19
申请号：US16315687
申请日：2017-06-30
Inventor： Chang Woo LEE , Heoun Jeong GO , Su Hyeon KIM , Seo Yoon BAE
IPC: A01K67/027 , C12N15/85 , A61K31/7105 , A61P17/06
Abstract: Provided are a psoriasis-induced transgenic animal model overexpressing the Pellino homolog 1 (Peli1) gene according to doxycycline administration, and a use thereof. The transgenic animal model of the present disclosure exhibited similarity to phenotypes shown in patients with psoriasis, due to overexpression of the Pellino homolog 1 (Peli1) gene according to doxycycline administration. It is anticipated that the transgenic animal model may be usefully used in clinical studies, such as screening for a candidate drug for the treatment of psoriasis. Additionally, it is anticipated that a peptide derived from the Peli1 FHA domain targeting the FHA binding motif that inhibits normal substrate binding between a substrate protein and the Peli1 protein may be usefully used in the development of new drugs for psoriasis-associated diseases. Moreover, by confirming an expression level of the Peli1 protein, it is anticipated to be usefully used in evaluating the severity of patients with psoriasis.
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25.发明申请公开(公告)号：US20190269460A1
公开(公告)日：2019-09-05
申请号：US16414422
申请日：2019-05-16
Inventor： Namkug KIM , Guk Bae KIM , Beom Seok KO , Sang Wook LEE , Sei Hyun AHN , Byung Ho SON , Jong Won LEE
Abstract: The present invention relates to a customized surgical guide device and a customized surgical guide generating method and program. A customized surgical guide generating method comprises the steps of: acquiring body surface data and treatment area data from medical image data by a computer; a first shape data generating step, wherein the first shape data is data which corresponds to the shape of the body part cover; a target point setting step of setting one or more target points; setting individual first points on the body surface accessible to the target point with a medical tool; setting a guide tube length on the basis of a distance from the first point to the target point; and generating final shape data in which one or more guide tubes are combined to the first shape data by applying the guide tube length to the first point.
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Patent Agency Ranking
26.发明授权公开(公告)号：US10392344B2
公开(公告)日：2019-08-27
申请号：US14375412
申请日：2012-12-21
Applicant: THE ASAN FOUNDATION
Inventor： Sang Ju Lee , Seung Jun Oh , Dae Hyuk Moon , Jin Sook Ryu , Jae Seung Kim , Jong Jin Lee
IPC: C07C303/32 , C07B59/00 , C07C217/80 , C07C309/01 , C07D213/64 , C07D233/91 , C07D451/02 , C07H19/06 , C07D403/06 , C07C213/08 , C07D471/04 , C07C253/30 , A61K51/04
Abstract: The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [18F]fluoride in a method for preparing an organic [18F]fluoro compound by reacting an alkyl halide or an alkyl sulfonate with a [18F]fluoride, wherein a [18F]fluoride supported on a quaternary alkyl ammonium polymer support is eluted using a solution containing a metal salt or a quaternary ammonium salt with an adjusted pH, and a base is not additionally used. The present invention enables a labeling reaction without an additional base after precisely reflecting the concentration of a base absolutely necessary for the nucleophilic substitution of a [18F]fluoride or eluting a [18F]fluoride using a [18F]fluoride eluent with an adjusted pH, thereby stably obtaining a [18F]fluoride-labelled compound in a high yield, and is thus useful for production of fluorine-18-labelled radioactive medical supplies.
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公开(公告)号：US20190239730A1
公开(公告)日：2019-08-08
申请号：US16342900
申请日：2017-10-18
Applicant: THE ASAN FOUNDATION
Inventor： Seung-Jae MYUNG , Sang-Yeob KIM , Sang Mun BAE , Eun-Ju DO , Dong-Jun BAE
CPC classification number: A61B1/043 , A61B1/05 , A61B1/0661 , A61B1/31 , G01N21/64
Abstract: There is disclosed a multi-wavelength endoscopic system for imaging an observation site labeled with a plurality of fluorescent materials having different colors. The system includes an imaging unit configured to acquire image data by polarizing incident light reflected from the observation site in a first direction and a second direction perpendicular to the first direction, dividing a spectrum region of the incident light polarized in the first direction and the second direction into a plurality of spectrum channels and measuring the intensity of light for each of the spectrum channel. The system further includes a computing unit configured to store a single fluorescence spectrum extracted from sample image data obtained by single-treating the observation site with each of the fluorescent materials and configured to separate and output the image data obtained in the imaging unit using the single fluorescence spectrum so that each of the fluorescent materials is displayed separately.
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公开(公告)号：US20190203280A1
公开(公告)日：2019-07-04
申请号：US16331148
申请日：2017-09-06
Inventor： Yong SHIN , Yong Sub KIM
IPC: C12Q1/6848 , C12Q1/06 , C12Q1/689 , C12Q1/70 , C12Q1/6853 , C12Q1/6811 , C12Q1/6806 , C12Q1/686 , C07H21/02
CPC classification number: C12Q1/6848 , C07H21/02 , C12Q1/06 , C12Q1/68 , C12Q1/6806 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C12Q1/689 , C12Q1/70 , C12Y207/07006 , Y02A50/59
Abstract: A composition and a method for improving sensitivity and specificity of detection of nucleic acids, use dCas9 and gRNA, which binds to a target nucleic acid sequence, in amplification of nucleic acids including DNAs, RNAs, and the like increases efficiency in amplification of nucleic acids and thereby can ultimately improve sensitivity and specificity of a target diagnosis on the basis of a functional difference between Cas9 and dCas9.
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公开(公告)号：US20190118000A1
公开(公告)日：2019-04-25
申请号：US16213859
申请日：2018-12-07
Applicant: THE ASAN FOUNDATION
Inventor： Jung Won KWAK , Nurihyun JUNG , Byung Chul CHO , Seung Do AHN , Sang Wook LEE , Jae Beom BAE
IPC: A61N5/10
CPC classification number: A61N5/1065 , A61N5/1042 , A61N5/1071 , A61N5/1077 , A61N2005/1087 , A61N2005/1089 , A61N2005/1096
Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.
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30.发明申请公开(公告)号：US20180369610A1
公开(公告)日：2018-12-27
申请号：US16015974
申请日：2018-06-22
Inventor： Jung Won KWAK , Sang Wook LEE , Byung Chul CHO , Seung Do AHN , Won Sik CHOI , Woo Sang AHN , Chi Young JEONG , Seong Soo SHIN , Kyoung Jun YOON
Abstract: Disclosed are a radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, a radiotherapy system including the radiotherapy assistant apparatus, and method for the radiotherapy system. The radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, including at least: a magnetic field generator that generates a magnetic field that has a direction perpendicular to a movement direction of the photon beam, the magnetic field generator is disposed on a movement route along which the photon beam moves toward a target portion of the radiotherapy; and a magnetic field intensity adjuster that adjusts an intensity of the magnetic field generated by the magnetic field generator. The magnetic field generator disperses secondary electrons that have particular energy levels equal to or lower than a preset value.
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