公开(公告)号：US20250116674A1

公开(公告)日：2025-04-10

申请号：US18730454

申请日：2023-02-09

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CHU DE ST ETIENNE ,  COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA) ,  UNIVERSITÉ GRENOBLE ALPES ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： Nadia ALFAIDY-BENHAROUGA ,  Mohamed BENHAROUGA ,  Céline CHAULEUR ,  Tiphaine BARJAT

IPC: G01N33/68

Abstract: In the present invention, thanks to a prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient, inventors investigated the concentrations of protein biomarkers in the plasma of high risk pregnant women during the second and third trimesters to predict spontaneous preterm birth. Inventors demonstrated that PROK1 (Prokineticin 1) also called EG-VEGF (Endocrine Gland-derived Vascular Endothelial Growth Factor), is secreted by the placenta and exhibits increased serum levels in patients with sPTB, before 37 weeks of gestation, compared with uncomplicated pregnant women. More precisely, Women with spontaneous preterm birth exhibited higher concentrations of serum PROK1/EG-VEGF than uncomplicated patients at 20 weeks, 24 weeks, 28 weeks and 32 weeks. Accordingly, serum PROK1/EG-VEGF concentrations could be considered as biomarker of spontaneous preterm birth in high-risk pregnant women.

公开(公告)号：US12070273B2

公开(公告)日：2024-08-27

申请号：US16936885

申请日：2020-07-23

Applicant: THALES ,  ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DE METHODES ET PROCESSUS INDUSTRIELS—ARMINES ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE SAINT-ETIENNE

Inventor： Aymeric Pionteck ,  Baptiste Pierrat ,  Sébastien Gorges ,  Jean-Noël Albertini ,  Stéphane Avril

IPC: G01N33/48 ,  A61B34/10 ,  A61B90/00 ,  G01N33/50

CPC classification number: A61B34/10 ,  A61B90/37 ,  A61B90/39 ,  A61B2034/102 ,  A61B2034/107 ,  A61B2090/367 ,  A61B2090/376 ,  A61B2090/3966

Abstract: A device for medical imaging by X-ray is provided. More specifically, it relates to the simulation of the deployment of an endoprosthesis in order to assist the surgeon in an endovascular surgical procedure. The invention makes use of a single 2D image in order to determine certain characteristics of a simplified model of the endoprosthesis: 2D positions, and deployment value of the stents; to determine the inherent rotation of at least one stent; then to determine the deployment of a model representing the structure of the stents, initialized on the basis of the preceding steps, in a 3D model of a vascular structure.

公开(公告)号：US12005523B2

公开(公告)日：2024-06-11

申请号：US17257134

申请日：2019-07-12

Applicant: Universite Jean Monnet Saint Etienne ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： Florent Pigeon ,  Anthony Abou Saleh ,  Jean-Philippe Colombier-Cinquantin ,  Florence Garrelie

IPC: B23K26/00 ,  B23K26/0622 ,  B23K26/08 ,  B23K26/352 ,  B23K103/00

CPC classification number: B23K26/3584 ,  B23K26/0006 ,  B23K26/0624 ,  B23K26/08 ,  B23K2103/52

Abstract: The invention relates to a process for nanostructuring the surface of a solid material in order to form a regular pattern of nanostructures on said surface, comprising:

irradiating the surface by a plurality of pulse trains (20) of a femtosecond laser beam:

each pulse train (20) comprises at least two pulses (21, 22),
each pulse has a peak fluence, and a sum of the peak fluences of the pulses of a pulse train is between 10% and 70% of a threshold fluence corresponding to a material ablation threshold for one pulse for said material,
two consecutive pulses of a pulse train are separated by a peak-to-peak duration ΔT between 500 fs and 150 ps,
two consecutive pulse trains are separated by a duration greater than 10 ΔT,


obtaining a regular pattern of nanostructures on said portion of surface, having a spatial periodicity lower than 130 nm.

公开(公告)号：US11945965B2

公开(公告)日：2024-04-02

申请号：US16971059

申请日：2019-02-27

Applicant: ELKEM SILICONES France SAS ,  Institut National des Sciences Appliquées LYON ,  Universite Claude Bernard Lyon 1 ,  Centre national de la recherche scientifique ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： François Ganachaud ,  Daniel Portinha De Almeida ,  Etienne Fleury ,  Gabriel Duaux ,  Aymeric Genest ,  Emmanuel Pouget

IPC: C09D183/08 ,  B05D1/00 ,  B33Y70/00 ,  C08K3/36 ,  C08L83/08

CPC classification number: C09D183/08 ,  B05D1/00 ,  B33Y70/00 ,  C08K3/36 ,  C08L83/08

Abstract: Silicone material obtained by a reaction between:—at least one organopolysiloxane (A) that has a molar mass of less than 70,000 g/mol, preferably less than 50,000 g/mol, and contains siloxyl units I.1 and I.2; and—at least one organic compound (B) carrying at least two carboxylic acid groups and having no unsaturation.








Y
a

⁢

Z
b
1

⁢

SiO


4
-

(

a
+
b

)


2






(

I
⁢
.1

)







Z
c
2

⁢

SiO


4
-
c

2






(

I
⁢
.2

)

公开(公告)号：US20230416454A1

公开(公告)日：2023-12-28

申请号：US18265120

申请日：2021-11-29

Applicant: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN ,  Centre National De La Recherche Scientifique (CNRS) ,  Universite Claude Bernard-Lyon1 ,  Universite Jean Monnet Saint Etienne ,  INSA Lyon

Inventor： MARC SUTTER ,  CHRISTOPHE LE CLERC ,  MELISSA POLONI ,  MARION COLELLA ,  FRANCOISE FENOUILLOT-RIMLINGER ,  JULIEN BERNARD

IPC: C08G63/672 ,  C08G63/85

CPC classification number: C08G63/672 ,  C08G63/85 ,  C08G2250/00

Abstract: A polyester comprises ethylene 2,5 furandicarboxylate units and diethylene glycol units, the polyester having a melting temperature Tf of greater than or equal to 225° C., an intrinsic viscosity of greater than or equal to 0.65 dL/g, and in which the amount of diethylene glycol unit, denoted DEG, is less than 4 mol % and the quantity of ester functions in chain end situations is less than 100 meq/kg. A process for producing the polyester is disclosed.

公开(公告)号：US20230314426A1

公开(公告)日：2023-10-05

申请号：US18044008

申请日：2021-09-14

Applicant: UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  HOSPICES CIVILS DE LYON ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE ,  INSERM (Institut National de la Sante et de la Recherche Medicale)

Inventor： Le Duy DO ,  Jerome HONNORAT ,  Anne-Laurie PINTO ,  Christian Peter MORITZ ,  Jean-Christophe ANTOINE ,  Jean-Philippe CAMDESSANCHE ,  Sergio MUNIZ-CASTRILLO

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N2800/28 ,  G01N2800/52

Abstract: The invention relates to a process for identifying patients affected by an autoimmune neurological disease, comprising a step of detection of at least one type of anti-Argonaute autoantibodies (AGO-Abs) in a biological sample of an individual susceptible to be affected by said disease, wherein positive detection of said at least one type of AGO-Abs means that said individual is affected by said autoimmune neurological disease.

公开(公告)号：US11717445B2

公开(公告)日：2023-08-08

申请号：US17554049

申请日：2021-12-17

Applicant: KERANOVA ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： Fabrizio Romano ,  Aurelien Bernard ,  Cyril Mauclair ,  Emmanuel Baubeau

IPC: A61F9/008

CPC classification number: A61F9/00827 ,  A61F9/0084 ,  A61F9/00825 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00897

Abstract: The present invention relates to apparatus for cutting out a human or animal tissue, such as a cornea, or a lens, said apparatus including a treatment device for producing a pattern consisting of at least two impact points in a focusing plane from a L.A.S.E.R. beam generated by a femtosecond laser (1), the treatment device being positioned downstream from said femtosecond laser, remarkable in that the treatment device comprises an optical focusing system (5) for focusing the L.A.S.E.R. beam in a cutting-out plane, and a control unit (6) able to control the displacement of the optical focusing system along an optical path of the L.A.S.E.R. beam for displacing the focusing plane in at least three respective cutting-out planes so as to form a stack of surfaces for cutting out the tissue.

公开(公告)号：US20230234891A1

公开(公告)日：2023-07-27

申请号：US18007637

申请日：2021-06-02

Applicant: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEEN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE CLAUDE BERNARD LYON I ,  UNIVERSITE JEAN MONNET SAINT-ETIENNE

Inventor： Thomas PERIE ,  Eric LINTINGRE ,  Marie Camille AUSCHER ,  Zoé BUNIAZET ,  Claire DELAROA ,  Philippe CASSAGNAU ,  René FULCHIRON

IPC: C04B35/634 ,  C04B35/638 ,  C04B35/64

CPC classification number: C04B35/63496 ,  C04B35/6344 ,  C04B35/63408 ,  C04B35/638 ,  C04B35/64 ,  C04B2235/6022

Abstract: A binder for an injection moulding composition, the binder includes, in percentage by mass and for a total of 100%: 35% to 60% of a component (a), or polymer base, made of a polymer or a mixture of polymers, each of the polymer being non-amphiphilic and having a mass average molar mass greater than or equal to 5,000 g/mol, 30% to 55% of a component (b), or wax, made of a polymer or a mixture of polymers, each of the polymer being non-amphiphilic and having a mass average molar mass less than 5,000 g/mol, and less than 10% of an amphiphilic component (c), or surfactant, and less than 10% of other components (d). The polymer base comprising 2% to 15% of a styrene-ethylene-butylene-styrene copolymer (SEBS), in percentage by mass based on the mass of the binder.

公开(公告)号：US20220326239A1

公开(公告)日：2022-10-13

申请号：US17610764

申请日：2020-05-14

Applicant: UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE ,  BIOSPEEDIA

Inventor： Bruno POZZETTO ,  Evelyne BEGAUD ,  Yves GERMANI ,  Cyrille HADDAR ,  Anne CARRICAJO

IPC: G01N33/569 ,  C12Q1/14 ,  G01N33/543

Abstract: The present invention relates to a method for diagnosing in vitro a pneumococcal infection (Streptococcus pneumoniae), comprising at least two steps of detecting a pneumococcal antigen: (i) on a sample of secretions from the airways of a patient, and (ii) on the same sample after dilution.

公开(公告)号：US20210178096A1

公开(公告)日：2021-06-17

申请号：US16074337

申请日：2017-02-02

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： Marc THEVENET ,  Patricia VIRET

IPC: A61M16/00 ,  A61G11/00 ,  A61M16/20 ,  A61M21/00

Abstract: The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.