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公开(公告)号：US09931472B2
公开(公告)日：2018-04-03
申请号：US14395133
申请日：2013-04-17
Applicant: UNIVERSITEIT ANTWERPEN , VOXDALE BVBA
Inventor： Pierre Van Damme , Vanessa Vankerckhoven , Stijn Verwulgen , Ruben Camerlynck , Wouter Coemans , Linda Scheelen , Koen Catharina Lodewijk Beyers , Bart Verleije , Wim Boudewijns
CPC classification number: A61M5/31501 , A61M5/2425 , A61M5/2466 , A61M5/3232 , A61M5/326 , A61M5/3271 , A61M5/3272 , A61M5/3293 , A61M5/345 , A61M5/425 , A61M5/46 , A61M2005/31508 , A61M2005/3151
Abstract: An intradermal injection device comprises a housing, a foot with an opening for passage of a needle; a reservoir movably mounted in the housing, and having a hollow space for holding a fluid; a hollow needle movably mounted in the housing and having a first end for penetrating the subject's skin and a second end for penetrating the reservoir, a plunger movably mounted in the housing for moving the needle through the opening for penetrating the subject's skin, and for pressing the fluid out of the reservoir. The reservoir is frictionally mounted inside the housing by first friction means, and the plunger is frictionally mounted to the reservoir by second friction means. The force to overcome the second friction is larger than the force to overcome the first friction.
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公开(公告)号：US09486541B2
公开(公告)日：2016-11-08
申请号：US13932727
申请日：2013-07-01
Applicant: Mayo Foundation for Medical Education and Research , VIB VZW , Universiteit Antwerpen , The University of British Columbia , The University of Manchester
Inventor： Michael L. Hutton , Matthew Charles Baker , Jennifer Mae Gass , Rosa Rademakers , Jason Eriksen , Stuart M. Pickering-Brown , Ian Reid Alexander Mackenzie , Howard Feldman , Samir Kumar-Singh , Christine Van Broeckhoven , Marc Cruts , Ashley Diane Cannon
IPC: A61K48/00 , C07K14/435 , C12Q1/68
CPC classification number: A61K48/005 , C07K14/435 , C12Q1/6809 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
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公开(公告)号：US09373180B2
公开(公告)日：2016-06-21
申请号：US14355286
申请日：2012-10-30
Applicant: UNIVERSITEIT ANTWERPEN , CWI
Inventor： Kees Joost Batenburg , Jan Sijbers
CPC classification number: G06T11/005 , A61B6/508 , A61B6/583 , G06T2211/424 , G06T2211/436
Abstract: A method for determining a projection angle for use in tomographic imaging comprises obtaining projection data including at least one projection view from at least one projection angle. The at least one projection view is generated by scanning a test object with a tomographic imaging device. Each projection view comprises at least one observation value obtained at least one detection location, providing a plurality of candidate projection angles, for each candidate projection angle, calculating a function value indicative of an amount of information that may be gained by adding to the projection data a further projection view generated by scanning of the test object with the tomographic imaging device from the candidate projection angle, and selecting a candidate projection angle from the plurality of candidate projection angles taking into account the function values. A corresponding system and computer program product also is provided.
Abstract translation: 用于确定用于断层摄影成像的投影角度的方法包括从至少一个投影角度获得包括至少一个投影视图的投影数据。 所述至少一个投影视图是通过用断层图像成像装置扫描测试对象而产生的。 每个投影视图包括至少一个观察值，其至少一个检测位置获得，为每个候选投影角度提供多个候选投影角度，计算指示可以通过添加到投影数据获得的信息量的函数值 通过从候选投影角度用断层图像成像装置扫描测试对象而产生的另一投影视图，并且考虑到功能值，从多个候选投影角度中选择候选投影角度。 还提供了相应的系统和计算机程序产品。
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公开(公告)号：US09346814B2
公开(公告)日：2016-05-24
申请号：US14372798
申请日：2013-01-17
Applicant: UNIVERSITEIT ANTWERPEN , Fox Chase Cancer Center
Inventor： Koen Jansen , Ingrid De Meester , Leen Heirbaut , Jonathan D Cheng , Jurgen Joossens , Koen Augustyns , Pieter Van Der Veken
IPC: C07D401/12 , C07D487/04 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D487/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.
Abstract translation: 本发明涉及对FAP（成纤维细胞活化蛋白）具有高选择性和特异性的新型抑制剂。 所述抑制剂可用作人和/或兽医药物，特别是用于治疗和/或预防FAP相关疾病，例如但不限于增殖性疾病。
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公开(公告)号：US20160114048A1
公开(公告)日：2016-04-28
申请号：US14891065
申请日：2014-05-14
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Arnout Everaert , Annick Ludwig , Dave Van Den Plas , Wim Weyenberg
CPC classification number: A61K47/38 , A61K9/0048 , A61K31/352 , A61K38/38 , A61K38/47 , A61K47/26 , C12Y302/01017
Abstract: The present invention relates to a drug release formulation, in particular a sustained release formulation for ophthalmic applications and a method of preparing same. The method is based on the hydration of a given solid polymeric matrix material under mild conditions, allowing versatility with respect to the drug to be formulated. Both said solid polymeric matrix material as well the API hydrated formulation is an object of the present invention. The thus obtained material is particularly suitable for prolonged and sustained delivery of medication to the eye. Thus in a further aspect, the present invention provides the use of said solid polymeric matrix material as well the API hydrated formulation, in ophthalmic applications.
Abstract translation: 本发明涉及一种药物释放制剂，特别是用于眼科应用的缓释制剂及其制备方法。 该方法基于在温和条件下给定的固体聚合物基质材料的水合，允许配制药物的多功能性。 所述固体聚合物基质材料以及API水合制剂都是本发明的目的。 由此获得的材料特别适合于延长和持续地将药物递送至眼睛。 因此，在另一方面，本发明提供了在眼科应用中所述固体聚合物基质材料以及API水合制剂的用途。
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Patent Agency Ranking
公开(公告)号：US09153412B2
公开(公告)日：2015-10-06
申请号：US14367487
申请日：2012-12-19
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Johan Verbeeck , Gustaaf Van Tendeloo
IPC: H01J37/10 , H01J37/04 , H01J37/26 , G01N23/225
CPC classification number: H01J37/04 , G01N23/2251 , G01N2223/101 , H01J37/26 , H01J37/263 , H01J2237/1504 , H01J2237/24557 , H01J2237/24564 , H01J2237/2614
Abstract: A device is arranged for imparting an orbital angular momentum to a charged particle wave propagating along an axis in a charged particle beam generating apparatus. The device includes a first conductive element comprising a plurality of angularly spaced electrical conductors arranged around the axis, and a second conductive element. The first and second conductive elements are spaced apart along the direction of the axis, and are adapted for transmitting a charged particle wave propagating along the axis. A connecting means is adapted for supplying an electrical potential to the plurality of angularly spaced electrical conductors for inducing an angular gradient of the phase of the charged particle wave when transmitted along the axis, in which the projection along the axis of the electrical potential varies as a function of an angular position with respect to the axis.
Abstract translation: 一种装置被布置用于对带电粒子束产生装置中沿着轴传播的带电粒子波施加轨道角动量。 所述装置包括第一导电元件，所述第一导电元件包括绕所述轴线布置的多个角度间隔的电导体和第二导电元件。 第一和第二导电元件沿着轴线的方向间隔开，并且适于传输沿轴线传播的带电粒子波。 连接装置适于为多个角度间隔的电导体提供电势，用于当沿轴线传输时引起带电粒子波相位的角度梯度，其中沿电位轴的突起变化为 相对于轴的角度位置的函数。
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公开(公告)号：US20140346354A1
公开(公告)日：2014-11-27
申请号：US14367487
申请日：2012-12-19
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Johan Verbeeck , Gustaaf Van Tendeloo
CPC classification number: H01J37/04 , G01N23/2251 , G01N2223/101 , H01J37/26 , H01J37/263 , H01J2237/1504 , H01J2237/24557 , H01J2237/24564 , H01J2237/2614
Abstract: A device is arranged for imparting an orbital angular momentum to a charged particle wave propagating along an axis in a charged particle beam generating apparatus. The device includes a first conductive element comprising a plurality of angularly spaced electrical conductors arranged around the axis, and a second conductive element. The first and second conductive elements are spaced apart along the direction of the axis, and are adapted for transmitting a charged particle wave propagating along the axis. A connecting means is adapted for supplying an electrical potential to the plurality of angularly spaced electrical conductors for inducing an angular gradient of the phase of the charged particle wave when transmitted along the axis, in which the projection along the axis of the electrical potential varies as a function of an angular position with respect to the axis.
Abstract translation: 一种装置被布置用于对带电粒子束产生装置中沿着轴传播的带电粒子波施加轨道角动量。 所述装置包括第一导电元件，所述第一导电元件包括绕所述轴线布置的多个角度间隔的电导体和第二导电元件。 第一和第二导电元件沿着轴线的方向间隔开，并且适于传输沿轴线传播的带电粒子波。 连接装置适于为多个角度间隔的电导体提供电势，用于当沿轴线传输时引起带电粒子波相位的角度梯度，其中沿电位轴的突起变化为 相对于轴的角度位置的函数。
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公开(公告)号：US20250036004A1
公开(公告)日：2025-01-30
申请号：US18697071
申请日：2022-09-30
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Wim WENSELEERS , Jochen CAMPO , Stein VAN BEZOUW , Valentina PIA , Valentina MANICI
Abstract: A second-order nonlinear optical device, includes (i) an active layer and (ii) an electric field generator. The active layer includes a matrix material, and second-order nonlinear optical chromophores dispersed in the matrix material. Each chromophore has a conjugated system having at least a first nitrogen atom connected to a second nitrogen atom via a conjugated path and a positive charge localized on one of the nitrogen atoms. The chromophore is switchable between a first state in which the positive charge is localized on the first nitrogen atom and a second state in which the positive charge is localized on the second nitrogen atom, and under thermal equilibrium both states are populated. The electric field generator is for switching at least some of the chromophores from the first state to the second state or from the second state to the first state, or to reorient at least some of the chromophores.
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公开(公告)号：US20250000185A1
公开(公告)日：2025-01-02
申请号：US18705646
申请日：2022-10-25
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Lore PAUWELS , Stijn VERWULGEN
IPC: A41D13/02
Abstract: An overall includes a pants section having a waist edge, a bib section connected to the pants section at the frontside of the overall, at least a first suspender connected by a first outer end to the bib section and adapted to be positioned over a shoulder such that the bib section is held in place when worn. The waist edge is elongatable along at least a first elongatable portion such that a rear portion of the pants section can be lowered over the buttocks of the wearer when the wearer is sitting while a front portion of the pants section remains in place together with the connected bib section, the at least a first elongatable portion being connected to the bib section.
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公开(公告)号：US20240381897A1
公开(公告)日：2024-11-21
申请号：US18722303
申请日：2022-12-22
Applicant: UNIVERSITEIT ANTWERPEN
Inventor： Siegfried VLAEMINCK , Gudrun DE BOECK , Abbas ALLOUL
Abstract: The invention provides methods of increasing the reproductivity, growth rate and/or pigmentation of an aquatic animal, such as fish by feeding said aquatic animal with a feed composition comprising purple bacteria. The invention further provides feed compositions for use in such methods.
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