公开(公告)号：US10039287B2

公开(公告)日：2018-08-07

申请号：US15022759

申请日：2014-09-18

Applicant: UNIVERSITY OF MANITOBA

Inventor： Steve Whyard

IPC: C07H21/04 ,  A01N63/00 ,  C12N15/113 ,  A01K67/033

Abstract: Provided herein are modified insects having decreased expression of a testis-specific coding region compared to a control insect. In one embodiment, the modified insect includes the characteristic of reduced fertility, reduced fecundity, or a combination thereof, when compared to the control insect. Optionally and preferably, the competiveness of the modified insect is not significantly reduced compared to the control insect. Also included herein are methods for making a modified insect, and methods for using the modified insects, including making populations of modified insects and use of the modified insects in sterile insect technique for biological control.

公开(公告)号：US20180115256A1

公开(公告)日：2018-04-26

申请号：US15794553

申请日：2017-10-26

Applicant: University of Manitoba

Inventor： Ngai Man Ho ,  King Man Siu

IPC: H02M7/797 ,  H02M1/42

CPC classification number: H02M7/797 ,  H02M1/4225 ,  H02M7/217 ,  H02M2001/123 ,  Y02B70/126

Abstract: A bidirectional bridgeless buck-boost power converter circuit is provided that can function as both a voltage source inverter (VSI) circuit to transform direct current (DC) voltage to alternating current (AC) voltage and as a power factor corrector (PFC) circuit to transform AC voltage to DC voltage. The disclosed converter fully utilizes inductors to form a CL filter and buck-boost converter energy storage element. Thus, low inductance chokes are used in the converter, which leads to a higher power density and is more cost-effective. Further, the bridgeless configuration minimizes conduction losses of semiconductors, and coupled with the use of low inductance chokes this improves system efficiency.

公开(公告)号：US20170322246A1

公开(公告)日：2017-11-09

申请号：US15526566

申请日：2015-11-13

Applicant: University Of Manitoba

Inventor： Mana Yazdani ,  Behzad Kordi ,  Douglas J. Thomson

IPC: G01R29/08 ,  G01R15/26 ,  G01D5/14 ,  G01N27/24 ,  G01R19/25

CPC classification number: G01R29/0814 ,  G01D5/14 ,  G01N27/24 ,  G01R15/26 ,  G01R19/2513 ,  G01R29/0878

Abstract: A new passive wireless electric field sensor is disclosed. This sensor does not require direct attachment to a source of power which makes it passive. It is composed of a resonator loaded with varactors. The sensor is interrogated by a remotely located device transmitting and receiving the pulses of sine wave in the resonance frequency range of the sensor. Therefore, the sensor can be mounted in the vicinity of high voltage apparatus and interrogated from a safe distance.

公开(公告)号：US20170299643A1

公开(公告)日：2017-10-19

申请号：US15487125

申请日：2017-04-13

Applicant: University of Manitoba

Inventor： Vladimir Okhmatovski ,  Farhad Seikh Hosseini

IPC: G01R29/08

CPC classification number: G01R29/08

Abstract: A method for calculating electric field having contributions of an incident electric field from a source and an electric field emitted from another object distinct from the source but in a path of the incident electric field, which is often termed a “scatterer”. This method is formed by a new single-source integral equation which represents the electric field inside the scatterer as a superposition of spherical waves emanating from its boundary. Calculation of electric field using this method is particularly but not exclusively suited for applications such as fault detection in simulations of power systems, remote sensing of stratified structures such as ice, and circuit design concerning chips in electronic packages on circuit boards.

公开(公告)号：US20170251931A1

公开(公告)日：2017-09-07

申请号：US15450261

申请日：2017-03-06

Applicant: University of Manitoba

Inventor： Ammu Prakash ,  Sherif S. Sherif

IPC: A61B5/02 ,  G06T7/00 ,  G06T1/20 ,  G06T7/40 ,  G06K9/62 ,  G06T7/168 ,  A61B5/00 ,  G06T7/11

CPC classification number: A61B5/02007 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B5/6876 ,  A61B5/7264 ,  A61B2576/00 ,  G06K9/00147 ,  G06K9/622 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/168 ,  G06T7/40 ,  G06T2200/28 ,  G06T2207/10101 ,  G06T2207/30024 ,  G06T2207/30101

Abstract: Detection of intravascular plaque in OCT images is carried out by obtaining images of vascular tissue from a vascular component by OCT either in a static mode of a single image or in a dynamic mode where the images are obtained by scanning. The method acts by dividing the OCT image into different regular regions, calculating different texture features for each of the above regions with a reduced set of less than a full set of the 26 Haralick textural features, using a clustering algorithm to segment the image defined by its texture features calculated above into different regions and transforming the segmented image back from its representation using texture features to its space-domain representation. The method uses three or four texture features where the reduced sets can be f1, f 2, and f14 (ASM at 0°, Inertia at 0° and ASM at 90°).

公开(公告)号：US20170240970A1

公开(公告)日：2017-08-24

申请号：US15514654

申请日：2015-10-09

Applicant: University of Manitoba

Inventor： Richard Keijzer

IPC: C12Q1/68 ,  C12N15/113

CPC classification number: C12Q1/6883 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm, causing abdominal viscera to herniate into the thorax. A common genetic cause for CDH and the associated abnormal lung development has not been identified. We have found that human fetal hypoplastic CDH lungs have a specific microRNA miR-200/miR-10a signature, which changes in response to fetal therapy.

公开(公告)号：US09737586B2

公开(公告)日：2017-08-22

申请号：US14996440

申请日：2016-01-15

Applicant: University of Manitoba

Inventor： Michael P. Czubryt

IPC: A61K38/17 ,  C07H21/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/495

CPC classification number: A61K38/1709 ,  A61K38/17 ,  C07K14/4702 ,  C07K14/495

Abstract: Therapies and compositions for reducing collagen synthesis in mammalian cells and tissues wherein the targets are scleraxis, scleraxis-binding sites, receptor-regulated Smads, and/or binding sites for receptor-regulated Smads whereby synergistic interactions between scleraxis proteins and receptor-regulated Smads are reduced, inhibited, interfered with, stopped, and/or prevented thereby reducing, inhibiting and/or interfering with the activation of collagen 1α2 promoter thereby inhibiting collagen production in mammalian cells and tissues. Alternatively, the therapies and compositions may reduce, inhibit, interfere with, stop, and/or prevent binding of the collagen 1α2 promoter to DNA thereby inhibiting expression of the collagen 1α2 gene in mammalian cells and tissues.

公开(公告)号：US09689828B2

公开(公告)日：2017-06-27

申请号：US14353191

申请日：2012-10-10

Applicant: UNIVERSITY OF MANITOBA

Inventor： Greg E. Bridges ,  Douglas L. Thomson ,  Sharmistha Bhadra ,  Michael Freund

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N27/00 ,  G01N27/30 ,  H04Q9/00 ,  G01N33/18 ,  G01D3/032 ,  G01K7/24

CPC classification number: G01N27/302 ,  G01D3/032 ,  G01K7/24 ,  G01N33/18 ,  H04Q9/00 ,  H04Q2209/40 ,  H04Q2209/47 ,  H04Q2209/75

Abstract: Systems, devices, and/or methods for use in passive wireless transmission of one or more parameters such as, e.g., pH, temperature, etc. are described. The systems, devices, and/or methods may use a passive sensor located proximate a material and an interrogator that may be used to interrogate the passive sensor and to receive a signal from the passive sensor representative of the one or more parameters.

公开(公告)号：US20170027957A1

公开(公告)日：2017-02-02

申请号：US15106778

申请日：2014-12-17

Applicant: UNIVERSITY OF MANITOBA

Inventor： Paul FERNYHOUGH ,  Nigel A. CALCUTT

IPC: A61K31/5513 ,  A61K38/17 ,  A61K31/216 ,  A61K9/00

CPC classification number: A61K31/5513 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K31/216 ,  A61K31/46 ,  A61K31/496 ,  A61K38/1767 ,  A61K45/06 ,  A61K2300/00

Abstract: A composition for therapy of a peripheral neuropathy disorder in a subject in need thereof. The composition comprises an effective amount of an agent selected from a group consisting of pirenzepine, oxybutynin, muscarinic toxin 7, a muscarinic receptor antagonist, and combinations thereof, and a pharmacologically acceptable carrier and/or an excipient. The composition is useful for therapy of peripheral neuropathies exemplified by peripheral neuropathies induced by systemic diseases, peripheral neuropathies induced by metabolic diseases, chemotherapy-induced peripheral neuropathies, compression-induced peripheral neuropathies, peripheral neuropathies induced by exposure to dichloroacetate, immune-mediated peripheral neuropathies, peripheral neuropathies induced by infections, and genetically acquired peripheral neuropathies.

Abstract translation: 用于治疗有需要的受试者的周围神经病变的组合物。 该组合物包含有效量的选自哌仑西平，奥昔布宁，毒蕈碱毒素7，毒蕈碱性受体拮抗剂及其组合的药剂，以及药理学上可接受的载体和/或赋形剂。 该组合物可用于治疗由全身性疾病引起的周围神经病变，由代谢疾病引起的周围神经病变，化疗诱发的周围神经病变，压迫性外周神经病变，由暴露于二氯乙酸诱导的周围神经病变，免疫介导的周围神经病 ，感染引起的周围神经病变，以及遗传性获得性周围神经病变。

公开(公告)号：US20160355560A1

公开(公告)日：2016-12-08

申请号：US15117863

申请日：2015-02-10

Applicant: Jorg STETEFELD ,  UNIVERSITY OF MANITOBA

Inventor： Jorg Stetefeld

IPC: C07K14/475 ,  C07K16/18

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/70503 ,  C07K16/18 ,  C07K2317/34 ,  C07K2319/00

Abstract: Provided herein are fragments of Netrin-1 proteins, fragments of DCC proteins and NEO1 proteins, and antibodies to epitopes located within the fragments of Netrin-1, DCC, and/or NEO1. Also provided herein are methods for using the fragments and antibodies, including methods for inhibiting binding of Netrin-1 to an UNC5 protein, a DCC protein, and/or a NEO1 protein. Other methods provided herein include inducing apoptosis of a cell, and reducing formation of multimers of Netrin-1 proteins, and treating a subject having a cancer or at risk of having a cancer.

Abstract translation: 本文提供了Netrin-1蛋白的片段，DCC蛋白和NEO1蛋白的片段，以及位于Netrin-1，DCC和/或NEO1片段内的表位的抗体。 本文还提供了使用片段和抗体的方法，包括用于抑制Netrin-1与UNC5蛋白，DCC蛋白和/或NEO1蛋白的结合的方法。 本文提供的其它方法包括诱导细胞凋亡，并减少Netrin-1蛋白多聚体的形成，以及治疗患有癌症或有癌症风险的受试者。