公开(公告)号：US20240001358A1

公开(公告)日：2024-01-04

申请号：US17585914

申请日：2022-01-27

Applicant: Ortho-Clinical Diagnostics, Inc. ,  The Research Foundation for the State University of New York ,  University of Rochester

Inventor： Raymond F. Jakubowicz ,  Harold Warren ,  Benjamin Miller ,  Michael Bryan ,  Daniel Steiner ,  John Cognetti ,  Nathaniel Cady ,  Minhaz Abedin ,  Natalya Tokranova

IPC: B01L3/00 ,  G02B6/42 ,  G02B6/293

CPC classification number: B01L3/502715 ,  G02B6/4215 ,  G02B6/29305 ,  G02B6/4262 ,  B01L2300/0654 ,  B01L2300/0816

Abstract: An apparatus, methods, and a system for a photonic biosensor are disclosed. The photonic biosensor includes a substrate having a sample addition zone in fluid communication with a wicking zone and a sample detection zone. The substrate also includes an optical input port configured to optically couple to a light source and an optical output port configured to optically couple to a light detector. The photonic biosensor also includes a photonic integrated circuit (“PIC”) connected to the substrate. The PIC includes a first grating coupler aligned with the optical input port, a second grating coupler aligned with the optical output port, at least one waveguide between the first grating coupler and the second grating coupler, and at least one detection element disposed within the at least one waveguide.

公开(公告)号：US11860100B2

公开(公告)日：2024-01-02

申请号：US16964831

申请日：2019-01-25

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Stavros G. Demos ,  Chi Huang

IPC: G01N21/64 ,  G01N1/30

CPC classification number: G01N21/6458 ,  G01N1/30 ,  G01N2001/302

Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

公开(公告)号：US11845143B2

公开(公告)日：2023-12-19

申请号：US16629199

申请日：2018-07-06

Applicant: University of Rochester

Inventor： Daniel R. Brooks ,  Jonathan D. Ellis

IPC: B23K26/082 ,  B23K26/0622 ,  B23K26/06 ,  G02B13/00 ,  G02B26/10 ,  G02B27/00

CPC classification number: B23K26/082 ,  B23K26/0624 ,  B23K26/0648 ,  G02B13/0005 ,  G02B13/0095 ,  G02B26/101 ,  G02B26/105 ,  G02B27/0031

Abstract: A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification.

公开(公告)号：US11808774B2

公开(公告)日：2023-11-07

申请号：US17157932

申请日：2021-01-25

Applicant: Georgetown University ,  University of Rochester

Inventor： Howard J. Federoff ,  Massimo S. Fiandaca ,  Amrita K. Cheema ,  Mark E. Mapstone

IPC: G01N33/92 ,  G01N33/68

CPC classification number: G01N33/92 ,  G01N33/6896 ,  G01N2405/04 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/60

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

公开(公告)号：US11789207B2

公开(公告)日：2023-10-17

申请号：US17016768

申请日：2020-09-10

Applicant: University of Rochester

Inventor： Jaime Cardenas ,  Juniyali Nauriyal

IPC: G02B6/30

CPC classification number: G02B6/305

Abstract: A device for attaching at least one optical fiber to a chip includes at least one nanowaveguide disposed on a substrate of a chip to be attached to an at least one off-chip fiber respectively. At least one oxide taper mode converter is disposed around a nanowaveguide end and in optical communication with and modally coupled to each of the at least one nanowaveguide respectively, and adapted such that each corresponding fiber of at least one off-chip fiber corresponds to a cleaved fiber end each cleaved fiber end to be fused to each oxide taper mode converter respectively to optically couple and mode match each cleaved fiber end to each of the nanowaveguide ends of each of the at least one nanowaveguide via the oxide taper mode converter by a modal coupling. A method for attaching at least one optical fiber to a chip is also described.

公开(公告)号：US11782192B2

公开(公告)日：2023-10-10

申请号：US17166294

申请日：2021-02-03

Applicant: University of Rochester

Inventor： David H. Lippman ,  Greg R. Schmidt

IPC: G02B3/08 ,  G02B3/00 ,  B29D11/00 ,  G02B27/00 ,  G02B1/04

CPC classification number: G02B3/0087 ,  B29D11/00355 ,  G02B1/041 ,  G02B27/0062

Abstract: A GRIN optic having an optical axis (z-direction) and a GRIN profile varying in the x and y-directions, the profile having one or more discontinuities extending in the x-y direction. The discontinuities may form a non-closed shape or have a non-smooth rectilinear shape. The GRIN optic may have plane-parallel surfaces. A method of designing a GRIN optic which includes mapping discretized elements in the light output specification to array elements of a linear GRIN array elements, identifying for each array element, a base refractive index n0, a gradient magnitude α, and a gradient direction θG capable of directing a beamlet from the light source to a corresponding location in the light output specification, and constructing a piecewise-continuous freeform GRIN profile of the GRIN optic by integrating the discrete linear GRIN array elements into a continuous refractive index profile.

公开(公告)号：US11776428B1

公开(公告)日：2023-10-03

申请号：US16234420

申请日：2018-12-27

Applicant: University of Rochester

Inventor： Jonathan Stone ,  Ahmed E. Ghazi

IPC: G09B23/30 ,  G09B23/34

CPC classification number: G09B23/303 ,  G09B23/34

Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.

公开(公告)号：US20230293642A9

公开(公告)日：2023-09-21

申请号：US17719580

申请日：2022-04-13

Applicant: University of Miami ,  University of Rochester ,  UCL Business LTD

Inventor： Stephan L. ZUCHNER ,  Adriana REBELO ,  Andrea CORTESE ,  Rong Grace ZHAI ,  David N. HERRMANN

IPC: A61K38/44 ,  A61P25/28 ,  A61K31/198 ,  A61K31/352 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/426 ,  A61K31/428 ,  A61K31/473 ,  A61K31/499 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7105 ,  A61K38/46 ,  A61K48/00 ,  C12N9/04 ,  C12N15/113 ,  C12N15/86 ,  C12Q1/6883 ,  G01N33/66

CPC classification number: A61K38/443 ,  A61P25/28 ,  A61K31/198 ,  A61K31/352 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/426 ,  A61K31/428 ,  A61K31/473 ,  A61K31/499 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7105 ,  A61K38/465 ,  A61K48/005 ,  C12N9/0006 ,  C12N15/1137 ,  C12N15/86 ,  C12Q1/6883 ,  C12Y101/01014 ,  G01N33/66 ,  C12N2310/11 ,  C12N2750/14143 ,  C12Q2600/156

Abstract: The present disclosure relates to methods of detecting and treating inherited neuropathy.

公开(公告)号：US20230293594A1

公开(公告)日：2023-09-21

申请号：US18135543

申请日：2023-04-17

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. GOLDMAN ,  Maiken NEDERGAARD

IPC: A61K35/30 ,  A61P25/18 ,  A61K31/495 ,  C12N5/0735 ,  C12N5/074

CPC classification number: A61K35/30 ,  A61K31/495 ,  A61P25/18 ,  C12N5/0606 ,  C12N5/0696 ,  A61K9/0019

Abstract: The present disclosure is directed to a method of treating a neuropsychiatric disorder. This method involves selecting a subject having the neuropsychiatric disorder and administering to the selected subject a preparation of glial progenitor cells at a dosage effective to treat the neuropsychiatric disorder in the subject. Another aspect of the disclosure is directed to a method of treating a neuropsychiatric disorder that includes selecting a subject having the neuropsychiatric disorder and administering, to the selected subject, a potassium (K+) channel activator at a dosage effective to restore normal brain interstitial glial K+ levels in the selected subject and treat the neuropsychiatric disorder is also disclosed.

公开(公告)号：US20230292719A1

公开(公告)日：2023-09-21

申请号：US18045148

申请日：2022-10-08

Applicant: UNIVERSITY OF ROCHESTER ,  UNIVERSITY OF COPENHAGEN

Inventor： Steven A. GOLDMAN ,  Ricardo de Costa Barbedo VIEIRA

IPC: A01K67/027

CPC classification number: A01K67/0271 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0318

Abstract: A chimeric non-human mammal disease model, wherein (1) at least 30% of all the glial cells in the corpus callosum of the chimeric non-human mammal are human glial cells, and/or (2) at least 5% of all of the glial cells in the white matter of the brain and/or brain stem of the chimeric non-human mammal are human glial cells, and wherein the human glial cells comprise a combination of a first group of human glial cells tagged with a first label and a second group of human glial cells tagged with a second label that is distinguishable from the first label.