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21.发明公开公开(公告)号：US20230242872A1
公开(公告)日：2023-08-03
申请号：US18114022
申请日：2023-02-24
Applicant: The Board of Trustees of the Leland Stanford Junior University , Worcester Polytechnic Institute
Inventor： Utkan Demirci , Erkan Tüzel , James Leonard Kingsley , Thiruppathiraja Chinnasamy
CPC classification number: C12N5/0612 , B01L3/502746 , B01L3/502761 , C12M47/04
Abstract: A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber.
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公开(公告)号：US20230192548A1
公开(公告)日：2023-06-22
申请号：US18110484
申请日：2023-02-16
Applicant: Worcester Polytechnic Institute
Inventor： Shuai Wang , Nima Rahbar , Suzanne F. Scariata
CPC classification number: C04B24/14 , C04B41/63 , C12N11/14 , C12N9/88 , C12Y402/01001 , E01C7/147 , E01C7/35 , C04B2111/72
Abstract: Methods for repair of cracks and niches in concrete using carbonic anhydrase embedded in a gelatin, hydrogel, or other aqueous matrix are provided. A durable corrosion resistant concrete mix containing carbonic anhydrase is provided, as are methods of making and using the durable corrosion resistant concrete. Corrosion resistance and durability derive from decreased porosity compared to concrete without the enzyme, conferring decreased access of deleterious materials such as chloride ions to interior portions of the concrete.
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公开(公告)号：US20230175774A1
公开(公告)日：2023-06-08
申请号：US18103794
申请日：2023-01-31
Applicant: Worcester Polytechnic Institute
Inventor： Jamal S. Yagoobi , Mengqiao Yang , Mehrnoosh F. Dardashti
CPC classification number: F26B3/12 , F26B25/002 , F26B2200/18
Abstract: An atomizing spray dryer employs one or more stages defined by ultrasonic transducers in close proximity to a liquid feed opening forming a path of an atomization flow for producing uniform droplets from a close tolerance with the transducer. The atomization flow exits a gap between the transducer and an outer edge of the opening, such that the passed liquid is responsive to an oscillation of the transducer for forming the droplets. A conical or other suitably shaped transducer engages a substantially round liquid feed opening. Subsequent stages may include a circular, ring, or other suitable shape aligned to receive the atomization flow from a circumference of the conical base, or may also take any suitable shape, preferably to receive droplets directed by the first stage.
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公开(公告)号：US20230132688A1
公开(公告)日：2023-05-04
申请号：US17975437
申请日：2022-10-27
Applicant: Worcester Polytechnic Institute
Inventor： Jamal S. Yagoobi
Abstract: A combined electrohydrodynamic (EHD) and dielectrophoretic (DEP) cooling approach for a processor or similar electronics in a zero gravity environment is beneficial in space exploration. An EHD pumping mechanism is defined by an array of alternating, polarized electrodes surrounding a heat sink coupled to the processor for heat exchange, such as a thermally conductive layer or coating. The array may be circular, rectangular, or any suitable geometry, generally guided by a shape of the heat sink/processor. Cooling fluid is drawn or pumped towards the heat sink by EHD electrodes, and a dielectrophoretic (DEP) electrode disposed above the center of the heat sink extracts the generated vapor bubbles away from the heated surface with a diverging electrical field. One configuration calls for a radial arrangement of EHD electrodes drawing the cooling fluid towards a centrally located heat sink.
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公开(公告)号：US20230098674A1
公开(公告)日：2023-03-30
申请号：US17695215
申请日：2022-03-15
Inventor： Eben Alsberg , Anna D. Dikina , Marsha W. Rolle , Hannah A. Strobel
IPC: A61L27/38 , A61K35/42 , A61L27/58 , A61K35/32 , A61K35/44 , A61L27/54 , A61K35/28 , C12N5/071 , C12N5/077
Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.
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Patent Agency Ranking
公开(公告)号：US20230044374A1
公开(公告)日：2023-02-09
申请号：US17964555
申请日：2022-10-12
Applicant: Worcester Polytechnic Institute , Ascend Elements, Inc.
Inventor： Yan Wang , Diran Apelian , Haiyang Zou
Abstract: Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution.
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公开(公告)号：US20220380430A1
公开(公告)日：2022-12-01
申请号：US17749555
申请日：2022-05-20
Applicant: Worcester Polytechnic Institute
Inventor： Jagan Srinivasan , Douglas Reilly , Elizabeth DiLoreto
IPC: C07K14/575 , A61K31/7105 , C12N15/70 , G01N33/68 , A61K35/74
Abstract: Kits and methods for rescuing at least one neuropeptide in a subject are described herein, including identifying at least one neuropeptide and recombining a nucleic acid sequence of the neuropeptide to obtain a recombinant nucleic acid neuropeptide; cloning the recombinant nucleic acid neuropeptide into a plasmid to obtain a recombinant neuropeptide plasmid and transforming the recombinant neuropeptide plasmid into a bacterial cell to obtain a transformed neuropeptide bacterial feed; and feeding the bacterial feed to the subject thereby rescuing the neuropeptide in the subject.
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公开(公告)号：US11502345B2
公开(公告)日：2022-11-15
申请号：US17572079
申请日：2022-01-10
Applicant: Worcester Polytechnic Institute
Inventor： Yan Wang , Diran Apelian , Haiyang Zou
Abstract: Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution.
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公开(公告)号：US11485964B2
公开(公告)日：2022-11-01
申请号：US16931967
申请日：2020-07-17
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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公开(公告)号：US11436714B2
公开(公告)日：2022-09-06
申请号：US16999560
申请日：2020-08-21
Inventor： Jacob Whitehill , Anand Ramakrishnan , Erin Ottmar , Jennifer LoCasale-Crouch
IPC: G06K9/62 , G06T7/00 , G10L25/63 , G10L25/30 , G10L25/57 , G06N3/08 , G06N3/04 , G09B19/00 , G06V20/40 , G06V40/16
Abstract: Embodiments of the innovation relate to an emotional quality estimation device comprising a controller having a memory and a processor, the controller configured to execute a training engine with labelled training data to train a neural network and generate a classroom analysis machine, the labelled training data including historical video data and an associated classroom quality score table; receive a classroom observation video from a classroom environment; execute the classroom analysis machine relative to the classroom observation video from the classroom environment to generate an emotional quality score relating to the emotional quality of the classroom environment; and output the emotional quality score for the classroom environment.
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