公开(公告)号：US20100035875A1

公开(公告)日：2010-02-11

申请号：US12488406

申请日：2009-06-19

Applicant: Bing-Yan ZHU ,  Michael SIU ,  Steven R. MAGNUSON ,  Richard PASTOR ,  He HAIYING ,  Xiao YISONG ,  Zheng JIFU ,  Xu XING ,  Zhao JUNPING ,  Wendy LIU

Inventor： Bing-Yan ZHU ,  Michael SIU ,  Steven R. MAGNUSON ,  Richard PASTOR ,  He HAIYING ,  Xiao YISONG ,  Zheng JIFU ,  Xu XING ,  Zhao JUNPING ,  Wendy LIU

IPC: A61K31/437 ,  C07D471/04 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  A61P9/00 ,  A61P37/00 ,  A61P29/00 ,  A61P19/00 ,  A61P25/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Abstract translation: 其中R 1，R 2，R 3，R 4和R 5在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作JAK激酶抑制剂。 公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及治疗或减轻对患者中JAK激酶活性的抑制作用的疾病或病症的严重程度的方法。

公开(公告)号：US20090298806A1

公开(公告)日：2009-12-03

申请号：US12348879

申请日：2009-01-05

Applicant: Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang ,  Robert M. Scarborough

Inventor： Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang ,  Robert M. Scarborough

IPC: A61K31/422 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K31/454 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61K31/541 ,  A61K31/553 ,  A61P9/00

CPC classification number: C07D413/14 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

Abstract translation: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。

公开(公告)号：US20080269210A1

公开(公告)日：2008-10-30

申请号：US11951189

申请日：2007-12-05

Applicant: Georgette Castanedo ,  Jennafer Dotson ,  Richard Goldsmith ,  Janet Gunzner ,  Tim Heffron ,  Simon Mathieu ,  Alan Olivero ,  Daniel P. Sutherlin ,  Shumei Wang ,  Bing-Yan Zhu ,  Steven Staben ,  Vickie Tsui ,  Tracy Bayliss ,  Irina Chuckowree ,  Adrian Folkes ,  Nan Chi Wan

Inventor： Georgette Castanedo ,  Jennafer Dotson ,  Richard Goldsmith ,  Janet Gunzner ,  Tim Heffron ,  Simon Mathieu ,  Alan Olivero ,  Daniel P. Sutherlin ,  Shumei Wang ,  Bing-Yan Zhu ,  Steven Staben ,  Vickie Tsui ,  Tracy Bayliss ,  Irina Chuckowree ,  Adrian Folkes ,  Nan Chi Wan

IPC: A61K31/5377 ,  C07D495/04 ,  C07D413/14 ,  A61P35/00 ,  A61K31/519

CPC classification number: C07D491/048 ,  C07D495/04

Abstract: Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 式Ia-d的化合物，其中X是S或O，mor是吗啉基团，R 3是单环杂芳基，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的 其盐可用于调节脂质激酶（包括PI3K）的活性，以及​​用于治疗由脂质激酶介导的癌症等疾病。 公开了使用式Ia-d化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种疾病的方法。

公开(公告)号：US20080123214A1

公开(公告)日：2008-05-29

申请号：US11605741

申请日：2006-11-28

Applicant: Li-Yan Zhu ,  Chao-Hui Yang ,  Yen Fu ,  Ellis T. Cha

Inventor： Li-Yan Zhu ,  Chao-Hui Yang ,  Yen Fu ,  Ellis T. Cha

IPC: G11B21/02

CPC classification number: G11B5/581 ,  G11B5/6029 ,  G11B5/6035

Abstract: In a system and method for a non-contact measurement of the fly height of a slider above a magnetic data storage medium using electrostatic force, a slider with a read/write head flies over a magnetic data storage medium. A series of distinct voltages are applied between the slider and the magnetic data storage medium, and corresponding read-back signals are recorded. Using the recorded read-back signals, coefficients for an empirical curve-fit equation are calculated. The coefficients are normalized and converted into a fly height measurement.

公开(公告)号：US07369370B2

公开(公告)日：2008-05-06

申请号：US11716947

申请日：2007-03-12

Applicant: Li-Yan Zhu

Inventor： Li-Yan Zhu

IPC: G11B5/127

CPC classification number: G11B5/3912 ,  B82Y10/00 ,  B82Y25/00 ,  G11B5/40 ,  G11B5/4806 ,  G11B2005/3996

Abstract: A method for preventing electrostatic discharge (ESD) damage in the head-suspension assembly (HSA) construction process. The method includes the use of a novel GMR magnetic recording head on a conductive slider substrate, the GMR head being electrically connected to the substrate and its conducting leads having balanced resistances between the leads and the substrate. By establishing an electrical connection between the GMR head and the slider substrate, the entire HSA can be grounded during its construction. By also grounding any nearby conducting elements that could inadvertently contact the HSA or its parts, no accumulated tribocharges can discharge through the sensitive GMR sensor element.

Abstract translation: 一种用于防止头悬挂组件（HSA）施工过程中的静电放电（ESD）损坏的方法。 该方法包括在导电滑块基板上使用新颖的GMR磁记录头，该GMR磁头电连接至该基板及其导线，该引线在引线与该基板之间具有平衡的电阻。 通过在GMR头和滑块基板之间建立电连接，整个HSA可在其施工期间接地。 通过将任何可能无意中接触HSA或其部件的导电元件接地，也不会通过敏感的GMR传感器元件放电累积的摩托车充电。

公开(公告)号：US07342750B2

公开(公告)日：2008-03-11

申请号：US10870082

申请日：2004-06-16

Applicant: Chao-Hui Yang ,  Yen Fu ,  Li-Yan Zhu ,  Manny Hernandez ,  Ellis T. Cha ,  Yong Luo

Inventor： Chao-Hui Yang ,  Yen Fu ,  Li-Yan Zhu ,  Manny Hernandez ,  Ellis T. Cha ,  Yong Luo

IPC: G11B5/48

CPC classification number: G11B5/486 ,  G11B5/484 ,  H05K1/0228 ,  H05K1/056 ,  H05K3/4685 ,  H05K2201/09554 ,  H05K2201/0969 ,  H05K2201/097

Abstract: An externally wireless laminated suspension for a hard disk drive are disclosed. In one embodiment, the externally wireless laminated suspension has an insulating layer to electrically isolate a first and second electrical trace from a conductive support layer. The second electrical trace crosses over the first electrical trace. The first electrical trace may be made of a first part on one side of the second electrical trace and a second part on the opposite side of the electrical trace. A conductive island area may be patterned into the support layer. The conductive island area may electrically couple the first part of the first electrical trace to the second part. The number of crossover points that the first electrical trace has may equal the number of crossover points that the second electrical trace has.

Abstract translation: 公开了一种用于硬盘驱动器的外部无线层叠悬架。 在一个实施例中，外部无线层叠悬架具有绝缘层，以将第一和第二电迹线与导电支撑层电隔离。 第二电迹线穿过第一电迹线。 第一电迹线可以由第二电迹线的一侧上的第一部分和在电迹线的相对侧上的第二部分制成。 导电岛区域可以被图案化成支撑层。 导电岛区域可以将第一电迹线的第一部分电耦合到第二部分。 第一电迹线具有的交叉点的数量可以等于第二电迹线具有的交叉点的数量。

公开(公告)号：US07314874B2

公开(公告)日：2008-01-01

申请号：US10942733

申请日：2004-09-15

Applicant: Bing-Yan Zhu ,  Penglie Zhang ,  Wenrong Huang ,  Robert M. Scarborough, deceased

Inventor： Bing-Yan Zhu ,  Penglie Zhang ,  Wenrong Huang ,  Robert M. Scarborough, deceased

IPC: C07D401/02 ,  A61K31/44

CPC classification number: A61K31/44 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/48 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/616 ,  A61K45/06 ,  A61K2201/094 ,  C07C237/42 ,  C07C255/60 ,  C07C257/18 ,  C07C259/18 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D249/08 ,  C07D295/125 ,  C07D333/38 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

Abstract: Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。

公开(公告)号：US07287313B2

公开(公告)日：2007-10-30

申请号：US11172297

申请日：2005-06-30

Applicant: Yimin Guo ,  Li-Yan Zhu

Inventor： Yimin Guo ,  Li-Yan Zhu

IPC: G11B5/127 ,  H04R31/00

CPC classification number: B82Y25/00 ,  B82Y10/00 ,  G11B5/3163 ,  G11B5/3169 ,  G11B5/3173 ,  G11B5/3903 ,  G11B5/3932 ,  G11B2005/0008 ,  G11B2005/3996 ,  H01F10/3268 ,  Y10T29/49021 ,  Y10T29/49034 ,  Y10T29/49036 ,  Y10T29/49037 ,  Y10T29/49041 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/4905 ,  Y10T29/49052

Abstract: A method is provided for preserving the transverse biasing of a GMR (or MR) read head during back-end processing. In a first preferred embodiment, the method comprises magnetizing the longitudinal biasing layers of the read head in a transverse direction, so that the resulting field at the position of the transverse biasing layer places it in a minimum of potential energy which stabilizes its direction. The field of the longitudinal biasing layer is then reset to the longitudinal direction in a manner which maintains the transverse biasing direction. In a second embodiment, a novel fixture for mounting the read head during processing includes a magnetic portion which stabilizes the transverse bias of the read head. The two methods may be used singly or in combination.

Abstract translation: 提供了一种用于在后端处理期间保持GMR（或MR）读取头的横向偏置的方法。 在第一优选实施例中，该方法包括在横向上磁化读头的纵向偏置层，使得在横向偏置层的位置处的所得场将其置于稳定其方向的最小势能中。 然后纵向偏置层的场以保持横向偏压方向的方式复位到纵向方向。 在第二实施例中，用于在处理期间安装读取头的新型夹具包括稳定读取头的横向偏压的磁性部分。 这两种方法可以单独使用或组合使用。

公开(公告)号：US20070233533A1

公开(公告)日：2007-10-04

申请号：US11617751

申请日：2006-12-29

Applicant: Yun-Feng Xie ,  Chun-Yan Zhu

Inventor： Yun-Feng Xie ,  Chun-Yan Zhu

IPC: G06F9/44

CPC classification number: G06Q10/06 ,  G06Q10/06315 ,  G06Q30/0201

Abstract: A system for creating a work order is provided, the system comprising an information downloading module, a work order selecting module and a work order creating module. The information downloading module downloads basic work order information. The work order selecting module selects a work order according to the basic work order information, and generates a selection result. The work order creating module creates a work order according to the selection result, and applies a created work order to a corresponding work field. A method for creating a work order is also provided.

Abstract translation: 提供了一种用于创建工单的系统，该系统包括信息下载模块，工单选择模块和工单创建模块。 信息下载模块下载基本工单信息。 工单选择模块根据基本工单信息选择工单，生成选择结果。 工单创建模块根据选择结果创建工单，并将创建的工单发送到相应的工作字段。 还提供了创建工单的方法。

公开(公告)号：US20070185092A1

公开(公告)日：2007-08-09

申请号：US11620615

申请日：2007-01-05

Applicant: Bing-Yan Zhu ,  Shawn Bauer ,  Zhaozhong Jia ,  Yonghong Song ,  Gary Probst ,  Yanchen Zhang ,  Robert Scarborough

Inventor： Bing-Yan Zhu ,  Shawn Bauer ,  Zhaozhong Jia ,  Yonghong Song ,  Gary Probst ,  Yanchen Zhang ,  Robert Scarborough

IPC: A61K31/551 ,  A61K31/502 ,  A61K31/513 ,  A61K31/497 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  C07D409/14

CPC classification number: C07D409/14 ,  C07D333/38 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

Abstract translation: 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。