Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
Abstract:
A time domain signal analysis method is provided. The signal analysis method includes the following steps. A signal to be analyzed is received. The signal to be analyzed is iteratively sifted by using Empirical Mode Decomposition (EMD) to extract at least one intrinsic function (IMF). A normalized Hilbert transform is performed on the IMF. The transformed IMF includes phase information. The transformed IMF is processed by means of phase processing to obtain the processed IMF including angular frequency information. The foregoing signal analysis method could be utilized in an ultrasound imaging system to identify image information of ultrasound images.
Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
Abstract:
A method of forming contact openings in a semiconductor device including providing a semiconducting substrate; forming an etch stop layer on said semiconducting substrate; forming a dielectric layer on said etch stop layer; forming a bottom anti-reflective coating (BARC) on said dielectric layer; forming and patterning a mask on said BARC layer; and, forming at least a first contact opening exposing said etch stop layer by a first etching process.
Abstract:
A derailleur system for bicycle is constructed to include an annular plate holding at least two gears, a bracket assembly rotated to a center hole of the annular plate to hold a transmission shaft, a driven gear wheel set pivoted to the transmission shaft and having a driven gear wheel meshed with one of the gears, a control device connected to a derailleur cable of the bicycle, and a driven member for selectively controlling the engagement between the driven gear wheels of the driven gear wheel set with the transmission shaft subject to the position of the control device.
Abstract:
A method to provide low dielectric constant voids between adjacent conducting lines in a semiconductor device. Narrowly spaced metal lines are formed on the substrate surface. A dielectric layer is deposited overlying the metal lines and the substrate surface. A high water content, water saturated, environment is created for the spin-on-glass process. A pseudo-water condition exists on the surface of the dielectric layer prior to the deposition of the spin-on-glass layer. The spin-on-glass layer is deposited overlying the dielectric layer. Voids form in the spin-on-glass layer between the narrowly spaced metal lines. The spin-on-glass layer is baked. The integrated circuit device is completed.
Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
Abstract:
Two new TLR2 agonists, VP1 and VP3, which are structural proteins of FMDV. Residues of VP3 responsible for TLR2 activation are identified. In vivo experiments showed that VP3-4xM2e is active as a vaccine adjuvant.
Abstract:
A semiconductor device includes a semiconducting substrate having CMOS transistors thereon. A composite etch stop layer including a lowermost silicon oxynitride portion and an uppermost silicon nitride portion is disposed on the semiconducting substrate including the CMOS transistors. At least one dielectric layer is on the composite etch stop layer. A first contact opening extends to a first level through the composite etch stop layer thickness and a second contact opening extends to a second level deeper than the first level through the composite etch stop layer.
Abstract:
A quick connector includes a main member, a housing, a sliding member and an elastic member. The main member has a chamber therein, two bores, a check valve and an elastic device urging the check valve sealing the bore. The housing has a big end, a small end and a sloping section. The big end is connected to the bore of the main member. The sliding member has an elongated bore, first and second ring portions, a plurality of apertures, and balls received in the apertures. The sliding member is inserted into the housing via the small end with the first ring portion out of the housing, the second ring portion in the housing and the sloping section of the housing between the first ring portion and the second ring portion. The elastic member urges the sliding member distal to the main member initially.