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公开(公告)号：US20150203454A1
公开(公告)日：2015-07-23
申请号：US14420859
申请日：2013-08-07
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Jackie Y. Ying , Lihong Liu , Hong Wu
IPC: C07D233/61 , A01N43/50
CPC classification number: C07D233/61 , A01N43/50 , A61K31/787
Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。
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公开(公告)号：US20150057470A1
公开(公告)日：2015-02-26
申请号：US14390757
申请日：2013-04-05
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Guangshun Yi , Yugen Zhang
IPC: C07C29/132
CPC classification number: C07C29/132 , C07C31/18 , C07C31/26
Abstract: A method for synthesizing a sugar alcohol comprising the step of hydrolyzing a polysaccharide in the presence of hydrogen ions (H+), an alcoholic reducing agent and a hydrogen transfer catalyst to form the sugar alcohol.
Abstract translation: 一种合成糖醇的方法，包括在氢离子（H +），醇还原剂和氢转移催化剂存在下水解多糖以形成糖醇的步骤。
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公开(公告)号：US20240049716A1
公开(公告)日：2024-02-15
申请号：US17425969
申请日：2020-01-21
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yugen Zhang , Jinquan Wang
IPC: A01N59/16 , C09D5/14 , C09D7/62 , A01N25/12 , A61K33/06 , A61K33/32 , A61K33/30 , A61K33/26 , A61K9/50 , A01P1/00
CPC classification number: A01N59/16 , C09D5/14 , C09D7/62 , A01N25/12 , A61K33/06 , A61K33/32 , A61K33/30 , A61K33/26 , A61K9/5015 , A01P1/00 , C08K9/04
Abstract: There is provided a composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex. There is also provided a method of preparing the composite comprising an inorganic metal or alloy core at least partially covered by a protection layer comprising a carboxylate salt, a metal oxide, a metal oxide salt or a metal-amino acid complex, comprising the step of mixing a metal or alloy with an acid, at elevated temperature for a time duration, optionally in the presence of a solvent. There is also provided use of a composite as an antimicrobial agent, and uses of a composite in the treatment or prophylaxis of microbial infection. There is also provided a method of inhibiting microbial activity or treating a microbial infection or disease comprising administering an antimicrobial composition comprising said composite as disclosed herein to a subject or applying the antimicrobial composition on a surface.
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公开(公告)号：US20220022457A1
公开(公告)日：2022-01-27
申请号：US17276866
申请日：2019-09-20
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yugen Zhang , Yuan Yuan
IPC: A01N43/90 , A01N43/653 , C07D519/00
Abstract: The present disclosure relates to compositions comprising an oligomer of Formula (I): having imidazolium and diammonium substituents; and an anti-fungal compound comprising at least one triazole group. The composition as described herein may be used as an anti-fungal composition for therapeutic and non-therapeutic applications.
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公开(公告)号：US20210400956A1
公开(公告)日：2021-12-30
申请号：US17281312
申请日：2019-09-24
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yugen Zhang , Siti Nurhanna Binte Riduan
Abstract: There is provided a core-shell composite comprising a core which comprises zinc metal and a shell that at least partially encapsulates the core, wherein the shell comprises a salt of the zinc metal as a cation with a sulphur-containing anion. There is also provided a method of forming a core-shell composite comprising the step of heating a mixture of zinc metal particle with elemental sulphur to form the core-shell composite, wherein the zinc metal particle forms the core of the core-shell composite, and wherein the shell of the said core-shell composite at least partially encapsulates the core and comprises a salt of the zinc metal as a cation with a sulphur-containing anion. There is also provided a method of killing or inhibiting the growth of a microbe, comprising the step of subjecting the microbe to the as-disclosed core-shell composite. There is also provided an anti-microbial coating on a substrate surface or an additive in a composition or a formulation comprising the as-disclosed core-shell composite.
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Patent Agency Ranking
公开(公告)号：US10927100B2
公开(公告)日：2021-02-23
申请号：US16617562
申请日：2018-06-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yugen Zhang , Yuan Yuan , Shu Wen Diane Lim
IPC: C07D403/12 , A61P31/04 , A01N43/50 , C08G73/06
Abstract: The present invention relates to an oligomer of formula (I) where the various groups are as defined in the specification. The present invention also relates to an oligomer or a polymer of formula (II) where the various groups are as defined in the specification. The present invention also relates to the methods for their preparation, antimicrobial composition, antimicrobial gel containing these oligomers and/or polymers of Formula (I) and (II), and uses of these oligomers and/or polymers in the treatment of a microbial infection or disease.
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公开(公告)号：US20180050328A1
公开(公告)日：2018-02-22
申请号：US15555189
申请日：2016-04-15
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Jinquan Wang
CPC classification number: B01J31/06 , B01D53/83 , B01D53/8671 , B01D2255/70 , B01D2257/504 , B01J35/1023 , B01J35/1028 , B01J35/1057 , B01J35/1061 , B01J37/00 , B01J2231/48 , B01J2531/002 , C07D233/16 , C07D317/38 , C08G61/02 , C08G83/006 , C08G2101/00 , C08G2261/132 , C08G2261/135 , C08G2261/143 , C08G2261/149 , C08G2261/45 , C08G2261/516 , C08G2261/72 , C08J9/36 , C08J2205/042 , C08J2365/00
Abstract: The present disclosure describes a process for making a hyperporous material for capture and conversion of carbon dioxide. The process comprises the steps a first self-polymerisation of benzyl halides via Friedel-Crafts reaction. In the second step the obtained hypercrosslinked polymer is further coupled with an amine or heterocyclic compound having at least one nitrogen ring atom. The invention also relates to the material obtained to the process and its use in catalytic reactions, for instance the conversion of epoxides to carbonates. Salt-modified porous hypercrosslinked polymers obtained according to the invention show a high BET surface (BET surface area up to 926 m2/g) combined with strong CO2 capture capacities (14.5 wt %). The nitrogen compound functionalized hypercrosslinked polymer catalyst shows improved conversion rates compared to known functionalized polystyrene materials and an excellent recyclability. A new type of imidazolium salt modified polymers shows especially high capture and conversion abilities. Carbonates can be produced in high yields according to the inventive used of the obtained polymers.
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公开(公告)号：US20180002267A1
公开(公告)日：2018-01-04
申请号：US15541925
申请日：2016-04-15
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Xiukai Li
CPC classification number: C07C51/25 , B01J23/002 , B01J23/22 , B01J23/28 , B01J23/30 , B01J37/0009 , B01J37/0063 , B01J37/08 , B01J2523/00 , B01J2523/55 , B01J2523/68 , B01J2523/69 , C07C29/60 , C07C51/235 , C07C57/04 , C07C33/03
Abstract: There is provided a method for synthesizing an alkenoic acid, in particular acrylic acid comprising the step of oxidizing an alkenyl alcohol in the presence of a metal oxide catalyst to form the alkenoic acid. The invention further provides a step of deoxydehydrating a polyol, including glycerol to obtain said alkenyl alcohol including an allyl alcohol.
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公开(公告)号：US09493424B2
公开(公告)日：2016-11-15
申请号：US14420859
申请日：2013-08-07
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Jackie Y. Ying , Lihong Liu , Hong Wu
IPC: A61K31/787 , C07D233/61 , A01N43/50
CPC classification number: C07D233/61 , A01N43/50 , A61K31/787
Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.
Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。
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公开(公告)号：US20160122450A1
公开(公告)日：2016-05-05
申请号：US14890052
申请日：2014-05-06
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Siew Ping Teong , Guangshun Yi
IPC: C08F114/14 , C07D307/50
CPC classification number: C08F114/14 , C07D307/46 , C07D307/50 , C08F8/30 , C08F8/32 , C08F8/44 , C08F112/14
Abstract: The present invention provides a polymer comprising an aliphatic backbone having a plurality of aromatic rings bonded thereon, said plurality of aromatic rings comprising a first aromatic ring type that has an alkyl halide group substitution on the aromatic ring and a second aromatic ring type that has an optionally substituted ammonium halide group substitution on the aromatic ring. The present invention also provides a method for making an optionally substituted furan, the method comprising the step of subjecting a sugar to a dehydration reaction in the presence of a catalyst comprising said polymer.
Abstract translation: 本发明提供一种包含脂肪族主链的聚合物，所述脂族主链具有多个键合在其上的芳环，所述多个芳环包含在芳香环上具有烷基卤基取代的第一芳香环型和具有芳香环的第二芳环型 在芳香环上任选取代的卤化铵基取代基。 本发明还提供了制备任选取代的呋喃的方法，所述方法包括在含有所述聚合物的催化剂存在下使糖进行脱水反应的步骤。
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