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公开(公告)号：US09688756B2
公开(公告)日：2017-06-27
申请号：US14367183
申请日：2012-12-17
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Seog Joon Han , Susie M Harris , Randal R Ketchem , Ji Lu , Mark L Michaels , Marc W Retter , Mei-Mei Tsai
CPC classification number: C07K16/28 , C07K16/00 , C07K2317/30 , C07K2317/524 , C07K2317/526 , C07K2317/72 , C07K2317/90 , C07K2317/94 , G01N33/6857 , G01N2333/705
Abstract: Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides.
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公开(公告)号：US20160264644A1
公开(公告)日：2016-09-15
申请号：US15171944
申请日：2016-06-02
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC: C07K14/71
CPC classification number: C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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公开(公告)号：US20160168223A1
公开(公告)日：2016-06-16
申请号：US15004281
申请日：2016-01-22
Applicant: Amgen Inc.
Inventor： Edward John Belouski , Murielle Marie Ellison , Agnes Eva Hamburger , Randy Ira Hecht , Yue-Sheng Li , Mark Leo Michaels , Jeonghoon Sun , Jing Xu
IPC: C07K14/50
CPC classification number: C07K14/50 , A61K38/00 , A61K38/1825 , A61K2039/505 , C07K16/18 , C07K2319/30
Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
Abstract translation: 本发明提供编码FGF21突变体多肽，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的核酸分子，以及使用此类核酸，多肽或药物组合物治疗代谢紊乱的方法。
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公开(公告)号：US20130288983A1
公开(公告)日：2013-10-31
申请号：US13932421
申请日：2013-07-01
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Huiquan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
IPC: C07K14/705 , A61K31/655 , A61K38/17 , A61K31/513
CPC classification number: C07K14/705 , A61K31/513 , A61K31/655 , A61K38/177 , A61K38/179 , A61K38/193 , A61K38/2013 , A61K38/212 , A61K38/45 , A61K38/50 , C07K14/71 , C12Y305/01001 , A61K2300/00
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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公开(公告)号：US11072640B2
公开(公告)日：2021-07-27
申请号：US15996232
申请日：2018-06-01
Applicant: AMGEN INC.
Inventor： Edward John Belouski , Murielle Marie Ellison , Agnes Eva Hamburger , Randy Ira Hecht , Yue-Sheng Li , Mark Leo Michaels , Jeonghoon Sun , Jing Xu
Abstract: The invention provides methods for treating non-alcoholic steatohepatitis (NASH) using FGF21 mutant polypeptides.
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Patent Agency Ranking
公开(公告)号：US10407487B2
公开(公告)日：2019-09-10
申请号：US15714726
申请日：2017-09-25
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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27.发明申请公开(公告)号：US20190085054A1
公开(公告)日：2019-03-21
申请号：US16209239
申请日：2018-12-04
Applicant: AMGEN INC.
Inventor： Jeonghoon Sun , Jason Charles O'Neill , Randal R. Ketchem , Randy Ira Hecht , Edward J. Belouski , Mark Leo Michaels
Abstract: There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
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28.发明授权公开(公告)号：US09610327B2
公开(公告)日：2017-04-04
申请号：US14366978
申请日：2012-12-19
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Huiquan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC: A61K35/00 , A61K38/00 , A61K38/17 , A61K45/06 , A61K31/513 , C07K14/71 , A61K31/655 , A61K31/7088 , A61K31/4164 , A61K31/7072 , A61K39/395
CPC classification number: A61K38/179 , A61K31/4164 , A61K31/513 , A61K31/655 , A61K31/7072 , A61K31/7088 , A61K39/395 , A61K45/06 , C07K14/71 , A61K2300/00
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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公开(公告)号：US09447165B2
公开(公告)日：2016-09-20
申请号：US14204460
申请日：2014-03-11
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC: C07K14/71
CPC classification number: C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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公开(公告)号：US09382309B2
公开(公告)日：2016-07-05
申请号：US14204460
申请日：2014-03-11
Applicant: Amgen Inc.
Inventor： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC: C07K14/71
Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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