摘要:
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要:
A peering relationship among two or more network appliances is established through an exchange of control messages among the network appliances. The peering relationship defines a cluster of peered network appliances, and at each network appliance of the cluster traffic flow state information for all the network appliances of the cluster is maintained. Network traffic associated with traffic flows of the network appliances of the cluster is managed according to the state information for the traffic flows. This managing of the network traffic may include forwarding among the network appliances of the cluster (i.e., to those of the appliances handling the respective flows) at least some of the network traffic associated with one or more of the traffic flows according to the state information for the one or more traffic flows. The traffic flows may be TCP connections or UDP flows.
摘要:
An antenna device has an antenna main body, a fixing member and a bolt. The antenna main body comprises an antenna element, female connectors provided at a first connector, a female screw section, and an engagement claw inserted into an antenna mount hole to make engagement with a lower side face of a roof panel. A fixing member comprises cables, male connectors provided at a second connector, the male connectors being provided to make mechanical engagement with female connectors without an electrical connection, and being connected to the cable, and a male screw section helically fitted to a female screw section, thereby tightening the female connectors, the male connectors, and a roof panel with one another. A bolt may be mounted between the male and female connectors to allow electrical connection therebetween.
摘要:
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要:
A plurality of directional sounders located in a region being monitored can be synchronously and sequentially activated in various patterns to establish an audibly defined exit route from the region. Emitted audio, from a respective sounder, can be different than the audio emitted by other activated sounders to provide a path and direction for evacuation to individuals in the vicinity of the exit route.
摘要:
This invention describes an electronic dictionary that is built and maintained by the user community. It is a single source to translate any word from any language into any other language. The dictionary resides with an online server. User with online connection specifies his/her native language and looks up any correct word, misspelled word, acronym, or phrase of any foreign language. The definitions and related information are also supplied by the user community. A user can also place advertisement. He/she can associate the advertisement with the entries in the dictionary. While the dictionary content is user maintained, the administrator has the full control.
摘要:
Disclosed are methods for chemical analysis, bacterial disinfection, oxidative destruction and/or mineralization of organic compounds comprising using zero-valent iron and/or zero-valent iron-containing bimetallic compounds, preferably in acidic solution and/or in the presence of oxygen.
摘要:
In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.