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公开(公告)号：US20100222420A1
公开(公告)日：2010-09-02
申请号：US12778739
申请日：2010-05-12
申请人： Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人： Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号： A61K31/7088 , C12N5/02
CPC分类号： A61K31/35
摘要： The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
摘要翻译： 本发明涉及癌症的治疗靶点。 特别地，本发明涉及靶向前列腺癌中EZH2表达的小分子和核酸。
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公开(公告)号：US20090239221A1
公开(公告)日：2009-09-24
申请号：US12272865
申请日：2008-11-18
申请人： Arul M. Chinnaiyan , Bo Han , Chandan Kumar
发明人： Arul M. Chinnaiyan , Bo Han , Chandan Kumar
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178
摘要： Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
摘要翻译： 描述了雄激素调节基因或持家基因和ETS家族成员基因在前列腺癌中的复发性基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
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公开(公告)号：US20090075833A1
公开(公告)日：2009-03-19
申请号：US12016498
申请日：2008-01-18
申请人： Arul M. Chinnaiyan , Jindan Yu , Rohit Mehra
发明人： Arul M. Chinnaiyan , Jindan Yu , Rohit Mehra
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及用于癌症的ADRB2标志物。
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公开(公告)号：US20090075284A1
公开(公告)日：2009-03-19
申请号：US12192539
申请日：2008-08-15
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
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公开(公告)号：US20090047269A1
公开(公告)日：2009-02-19
申请号：US12192681
申请日：2008-08-15
申请人： Arul M. Chinnaiyan , Arun Sreekumar
发明人： Arul M. Chinnaiyan , Arun Sreekumar
CPC分类号： C12N5/0693 , C12N15/113 , C12N2500/33 , G01N33/57434 , G01N33/6815 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer and methods of inhibiting the growth of a cell by altering the level of such metabolites.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物和通过改变这些代谢物的水平来抑制细胞生长的方法。
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公开(公告)号：US20080280771A1
公开(公告)日：2008-11-13
申请号：US11820377
申请日：2007-06-19
CPC分类号： C07K1/047 , B01J2219/00596 , B01J2219/00605 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , C07K1/1077 , C40B50/14 , G01N33/54386 , G01N33/6842
摘要： The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of the phosphorylation status of protein samples, including the generation and analysis of protein microarrays.
摘要翻译： 本发明涉及用于蛋白质分离和分析的自动化方法，系统和装置。 特别地，本发明提供了用于蛋白质样品的磷酸化状态的分离，鉴定和表征的自动化系统，包括蛋白质微阵列的产生和分析。
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公开(公告)号：US09938582B2
公开(公告)日：2018-04-10
申请号：US12882533
申请日：2010-09-15
申请人： Arul M. Chinnaiyan , Xiaosong Wang
发明人： Arul M. Chinnaiyan , Xiaosong Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , G01N2800/7028
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for prostate cancer.
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公开(公告)号：US20130261022A1
公开(公告)日：2013-10-03
申请号：US13796988
申请日：2013-03-12
IPC分类号： G01N33/493
CPC分类号： G01N33/493 , G01N33/57415 , G01N33/57434 , G01N2800/60
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer).
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在癌症中差异存在的代谢物和代谢物组（例如前列腺或乳腺癌）。
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公开(公告)号：US08524682B2
公开(公告)日：2013-09-03
申请号：US12778739
申请日：2010-05-12
申请人： Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
发明人： Arul M. Chinnaiyan , Sooryanarayana Lnu , Qi Cao
IPC分类号： C12N15/11
CPC分类号： A61K31/35
摘要： The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
摘要翻译： 本发明涉及癌症的治疗靶点。 特别地，本发明涉及靶向前列腺癌中EZH2表达的小分子和核酸。
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公开(公告)号：US20110104680A1
公开(公告)日：2011-05-05
申请号：US12893801
申请日：2010-09-29
申请人： Arul M. Chinnaiyan , Xiaosong Wang
发明人： Arul M. Chinnaiyan , Xiaosong Wang
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , Y10T436/143333
摘要： The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for lung cancer.
摘要翻译： 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及作为诊断标志物和肺癌临床靶标的复发性基因融合体。
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