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公开(公告)号：US09808449B2
公开(公告)日：2017-11-07
申请号：US14757822
申请日：2015-12-23
Applicant: Biogen MA Inc.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , A61K38/21 , A61K31/225 , A61K39/395 , A61K31/517 , A61K31/695 , A61K31/4545 , C07K16/28 , A61K31/4709 , C07D215/20 , C07D405/12 , C07D211/34 , C07D211/60 , C07D211/62 , C07D401/06 , A61K31/498 , A61K31/55
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号：US20150361029A1
公开(公告)日：2015-12-17
申请号：US14763893
申请日：2014-01-29
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Xiaogao Liu , Bin Ma , Hairuo Peng
IPC: C07C229/14 , C07D207/16 , C07D211/62 , C07C229/50 , C07C229/48 , C07D211/34 , C07F7/08 , A61K45/06 , A61K31/198 , A61K31/397 , A61K31/197 , A61K31/40 , A61K31/445 , A61K31/196 , A61K31/695 , C07D205/04
CPC classification number: C07C229/14 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/695 , A61K45/06 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/26 , C07C2602/44 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07F7/0812 , Y02A50/401
Abstract: Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.
Abstract translation: 式（I）化合物可调节一种或多种S 1 P受体的活性。 鞘氨醇1-磷酸（SIP）是一种溶血磷脂介质，通过刺激内皮细胞分化基因（EDG）受体家族的五个成员即S1P1，S1P2，S1P3，S1P4和S1P5（以前称为EDG1），诱发多种细胞反应 ，EDG5，EDG3，EDG6和EDG8）。 EDG受体是G蛋白偶联受体（GPCR），刺激通过激活异源三聚体G蛋白α（Ga。）亚基和β-gamma（G（）y）二聚体而传播第二信使信号。
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公开(公告)号：US11858926B2
公开(公告)日：2024-01-02
申请号：US17871157
申请日：2022-07-22
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D413/14 , C07D405/14 , C07D471/04 , A61P43/00 , A61P1/16
CPC classification number: C07D417/14 , A61P1/16 , A61P43/00 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07B2200/13
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US10961237B2
公开(公告)日：2021-03-30
申请号：US16534540
申请日：2019-08-07
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D413/14 , C07D405/14 , C07D471/04 , A61P43/00 , A61P1/16
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US10899753B2
公开(公告)日：2021-01-26
申请号：US16410725
申请日：2019-05-13
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Jürgen Schulz , Marta Nevalainen , Michael Dechantsreiter
IPC: C07D413/14 , C07D403/14 , C07D405/14
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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Patent Agency Ranking
公开(公告)号：US10166250B2
公开(公告)日：2019-01-01
申请号：US15783809
申请日：2017-10-13
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D205/04 , A61K31/395 , A61K31/695 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C309/14 , C07C311/51 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D217/24 , C07D257/04 , C07D305/08 , C07D403/06 , C07D417/06 , C07F9/38 , C07F9/40 , A61K31/085 , A61K31/11 , A61K31/18 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C255/54 , C07D215/227 , C07D217/04 , C07D239/74 , C07D277/64 , C07D401/06 , C07F7/08 , A61K31/137 , A61K31/165 , A61K31/185 , A61K31/198 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/401
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US20180028511A1
公开(公告)日：2018-02-01
申请号：US15644352
申请日：2017-07-07
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , A61K31/4545 , A61K31/4709 , A61K31/498 , C07K16/28 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/395 , A61K31/225 , C07D215/20 , C07D405/12 , C07D401/06 , C07D211/62 , C07D211/60 , A61K31/517 , C07D211/34
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号：US20170239280A1
公开(公告)日：2017-08-24
申请号：US15397421
申请日：2017-01-03
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/18 , A61K31/223 , A61K31/222 , A61K31/397 , A61K31/401 , A61K31/445 , A61K31/235 , A61K31/197 , A61K31/198 , A61K31/683 , A61K31/662 , A61K31/277 , A61K31/137 , A61K31/41 , A61K31/165 , A61K31/185 , A61K31/337 , A61K45/06
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US09708353B2
公开(公告)日：2017-07-18
申请号：US14620700
申请日：2015-02-12
Applicant: BIOGEN MA INC.
Inventor： Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07D263/24 , C07F9/6512 , C07C233/47 , C07C229/36 , C07C217/58 , C07D215/20 , C07F9/60 , C07D239/80
CPC classification number: C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US20170174710A1
公开(公告)日：2017-06-22
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D215/38 , C07D451/14 , A61K45/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
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