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公开(公告)号：US20190302093A1
公开(公告)日：2019-10-03
申请号：US16443699
申请日：2019-06-17
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei CHANG , Chiung-Han WANG
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a receiving mechanism to receive a carrier. The carrier includes a holding area that carries or has been exposed to the biological specimen. The device includes a camera module arranged to capture imagery of the holding area. The camera module includes an focusing motor operable to adjust a focal point of the camera. The device also includes a processor that is configured to utilize the camera module to determine, based on operations of the focusing motor, a volumetric property of the holding area and perform a set of analytic processes on at least a portion of the captured imagery of the holding area to determine one or more properties of the biological specimen.
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公开(公告)号：US20180348114A1
公开(公告)日：2018-12-06
申请号：US16101336
申请日：2018-08-10
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Hsuan-Yu Huang , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi
IPC: G01N15/14 , G02B21/34 , G06T7/00 , G02B21/24 , G01N33/487
CPC classification number: G01N15/1475 , A61B10/0058 , G01N15/1434 , G01N33/48728 , G01N2015/1006 , G01N2015/144 , G01N2015/1486 , G01N2015/1497 , G02B21/244 , G02B21/34 , G06T7/0012 , G06T2207/10056 , G06T2207/30241
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.
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公开(公告)号：US09664611B2
公开(公告)日：2017-05-30
申请号：US14711732
申请日：2015-05-13
Applicant: Bonraybio Co., Ltd.
Inventor： Hui-Ching Lu , Cheng-Teng Hsu
IPC: G01N21/03 , G01N33/487 , G01N21/80
CPC classification number: G01N21/0303 , G01N21/80 , G01N33/48778 , G01N2021/0389
Abstract: A testing equipment with a magnifying function includes a carrier, a cover and a magnifying part. The carrier has a specimen holding area formed on the top of the carrier. The cover is stacked on the specimen holding area of the carrier. The magnifying part disposed on the cover. The location of the magnifying part is corresponding to the location of the specimen holding area. The testing equipment of the present application has a simplified and cheap structure for a simple specimen testing.
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公开(公告)号：US12153039B2
公开(公告)日：2024-11-26
申请号：US18300322
申请日：2023-04-13
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Li-Sheng Chang , Hsiu-Chin Lee
IPC: G01N33/483 , C12N5/076 , G01N21/64
Abstract: Disclosed herein are methods for the detection of the presence of sperm DNA fragmentation in a semen sample. The methods include embedding of sperm cells of the semen sample in a gel, denaturing DNA of the sperm cells, and lysing the nuclear proteins of the sperm cells. The present method includes an ionic surfactant sodium dodycyl sulfate (SDS) and a chaotropic agent urea in the lysis solution for releasing DNA from protamine of chromosome, which significantly reduces the time required for lysis. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.
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公开(公告)号：US20230251241A1
公开(公告)日：2023-08-10
申请号：US18300322
申请日：2023-04-13
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Li-Sheng Chang , Hsiu-Chin Lee
IPC: G01N33/483 , C12N5/076
CPC classification number: G01N33/4833 , C12N5/061 , G01N2021/6439
Abstract: Disclosed herein are methods for the detection of the presence of sperm DNA fragmentation in a semen sample. The methods include embedding of sperm cells of the semen sample in a gel, denaturing DNA of the sperm cells, and lysing the nuclear proteins of the sperm cells. The present method includes an ionic surfactant sodium dodycyl sulfate (SDS) and a chaotropic agent urea in the lysis solution for releasing DNA from protamine of chromosome, which significantly reduces the time required for lysis. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.
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Patent Agency Ranking
公开(公告)号：US20220163507A1
公开(公告)日：2022-05-26
申请号：US17648901
申请日：2022-01-25
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
Abstract: Disclosed are verification techniques that can be implemented by a device that conducts biological tests to verify that the specimen holding area carries a valid biological specimen. In certain embodiments, the testing device includes a receiving mechanism to receive a carrier, and the carrier includes a holding area that is to carry or to be exposed to a biological specimen. The device can also include a camera module arranged to capture imagery of the carrier, and a processor. In some examples, the processor can capture the imagery of the carrier and identify a visual cue on the carrier. Then, the processor can verify, based on a manner of how the visual cue is displayed in the captured imagery, whether the holding area carries a valid biological specimen.
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公开(公告)号：US20220148224A1
公开(公告)日：2022-05-12
申请号：US17648887
申请日：2022-01-25
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
Abstract: Disclosed are calibration techniques that can be implemented by a device that conducts biological tests. In certain embodiments, the device for testing a biological specimen includes a receiving mechanism to receive a carrier, a camera module arranged to capture imagery of the carrier, and a processor. Some examples of the processor can detect a calibration mode trigger. In calibration mode, the processor can divide the captured imagery into segments and selectively perform one or more calibration procedures for each segment. Then, the processor records a calibration result for each segment.
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公开(公告)号：US10928378B2
公开(公告)日：2021-02-23
申请号：US17034433
申请日：2020-09-28
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei Chang , Chiung-Han Wang
Abstract: Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device may include a camera arranged to capture a plurality of images, including a first image and a second image, of the holding area. The device may include a positioning mechanism operable to adjust a relative location of the carrier to the camera. A processor in the device may utilize the camera module to: identify an edge of the first image; cause the positioning mechanism to adjust the relative location of the carrier to the camera in a manner such that, when the camera takes the second image, an edge of the second image aligns with the identified edge of the first image; and perform a set of analytic processes on a combined image from the first and second images.
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公开(公告)号：US20210010996A1
公开(公告)日：2021-01-14
申请号：US17034566
申请日：2020-09-28
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi , Chia-Wei CHANG , Chiung-Han WANG
Abstract: Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device includes a camera to capture a plurality of images of the holding area. A processor in the device may utilize the camera module to: adaptively select, based on the plurality of images of the holding area, an analytical algorithm suitable for a motion property that is characteristic of the biological specimen being tested; and perform a set of analytic processes that corresponds to the selected analytic algorithm on the captured imagery to generate an analytic result associated with the biological specimen.
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公开(公告)号：US10281386B2
公开(公告)日：2019-05-07
申请号：US15966479
申请日：2018-04-30
Applicant: Bonraybio Co., Ltd.
Inventor： Cheng-Teng Hsu , Hsuan-Yu Huang , Chih-Pin Chang , Kuang-Li Huang , Yu-Chiao Chi
Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.
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