公开(公告)号：US20090112278A1

公开(公告)日：2009-04-30

申请号：US12243733

申请日：2008-10-01

申请人： Brett Wingeier ,  Benjamin Pless

发明人： Brett Wingeier ,  Benjamin Pless

IPC分类号： A61N1/00

CPC分类号： A61N1/36025 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4094 ,  A61B5/6864 ,  A61B8/0808 ,  A61B18/02 ,  A61B18/14 ,  A61B90/10 ,  A61B2018/1807 ,  A61B2090/103 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/205 ,  A61N1/303 ,  A61N1/36017 ,  A61N5/0601

摘要： Disclosed are methods, devices, and systems for inducing neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Further disclosed are methods, devices, and systems for identifying where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces are also disclosed, including diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

摘要翻译： 公开了用于通过将颅骨/脑界面以颅骨形成的孔的形式聚焦刺激源，颅骨中天然存在的开窗或经颅通道来诱导神经调节的方法，装置和系统。 还公开了用于识别在哪里定位颅骨/脑界面的方法，装置和系统，可以与界面一起使用的附件以及用于控制通过界面传递的刺激的特征。 还公开了颅骨/脑界面的多种适应症，包括诊断和治疗诸如癫痫，运动障碍，抑郁症，阿尔茨海默病，孤独症，昏迷和疼痛的神经障碍和病症。

公开(公告)号：US20090112277A1

公开(公告)日：2009-04-30

申请号：US11929801

申请日：2007-10-30

申请人： Brett Wingeier ,  Benjamin Pless

发明人： Brett Wingeier ,  Benjamin Pless

IPC分类号： A61N1/05 ,  A61B18/00

CPC分类号： A61N1/0539 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B90/98 ,  A61B2018/1807 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/126 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/20 ,  A61N1/303 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/022 ,  A61N2007/0026

摘要： A method is disclosed for conveying a form of neuromodulation (e.g., electrical, chemical, optical, or thermal) from an external neuromodulation source interiorly of the skull to modulate neural activity. The method involves forming one or more apertures through or partially through the skull to provide an interface for delivering the neuromodulation. A method is disclosed for sensing one or more parameters characteristic of one or more states of the brain through an interface formed with one or more apertures extending all the way or part of the way through the skull. A device is disclosed that is implantable in the skull of a human patient to provide an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be provided in a wide variety of shapes and sizes with or without inner lumens. The channels may be configured for ion conduction of electrical signals, enabling DC or near DC stimulation of target neurons. Methods and devices for transferring energy (e.g., thermal energy) generated inside the skull to the outside of the skull and vice versa are also disclosed.

公开(公告)号：US20090112273A1

公开(公告)日：2009-04-30

申请号：US12234297

申请日：2008-09-19

申请人： Brett Wingeier ,  Benjamin Pless

发明人： Brett Wingeier ,  Benjamin Pless

IPC分类号： A61N1/00

CPC分类号： A61N1/0539 ,  A61B5/04 ,  A61B5/0478 ,  A61B18/02 ,  A61B18/14 ,  A61B90/98 ,  A61B2018/1807 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0002 ,  A61F2007/0056 ,  A61F2007/126 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/20 ,  A61N1/303 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/022 ,  A61N2007/0026

摘要： A method is disclosed for conveying a form of neuromodulation (e.g., electrical, chemical, optical, or thermal) from an external neuromodulation source interiorly of the skull to modulate neural activity. The method involves forming one or more apertures through or partially through the skull to provide an interface for delivering the neuromodulation. A method is disclosed for sensing one or more parameters characteristic of one or more states of the brain through an interface formed with one or more apertures extending all the way or part of the way through the skull. A device is disclosed that is implantable in the skull of a human patient to provide an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be provided in a wide variety of shapes and sizes with or without inner lumens. The channels may be configured for ion conduction of electrical signals, enabling DC or near DC stimulation of target neurons. Methods and devices for transferring energy (e.g., thermal energy) generated inside the skull to the outside of the skull and vice versa are also disclosed.

摘要翻译： 公开了用于从颅骨内部的外部神经调节源输送神经调节（例如电学，化学，光学或热学）形式以调节神经活动的方法。 该方法包括通过或部分穿过颅骨形成一个或多个孔，以提供用于递送神经调节的界面。 公开了一种用于通过由一个或多个延伸穿过颅骨的方式或部分延伸的一个或多个孔形成的界面来感测脑的一个或多个状态的一个或多个状态的一个或多个特征的方法。 公开了一种可植入人类患者颅骨的装置，以提供在颅骨外部与脑部之间的界面，该界面包括足以穿过颅骨的整个厚度的长度的通道，或至少部分 颅骨厚度 通道可以以具有或不具有内腔的多种形状和尺寸来提供。 通道可以被配置用于电信号的离子传导，使得能够对目标神经元进行DC或近DC刺激。 还公开了将头骨内产生的能量（例如，热能）转移到颅骨外部的方法和装置，反之亦然。