公开(公告)号：US20110127419A1

公开(公告)日：2011-06-02

申请号：US12788403

申请日：2010-05-27

Applicant: Bruce Thomson ,  Suzanne Ackloo

Inventor： Bruce Thomson ,  Suzanne Ackloo

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/004 ,  G01N30/02 ,  G01N30/7233 ,  B01D15/34

Abstract: A system and method for performing MS/MS of everything are provided. Ionisable materials separated in order of molecular weight in a plurality of mass ranges are received at a mass spectrometer system in a given order in time, each mass range comprising a respective center mass value and a respective width. The ionisable materials are ionised in the given order that each of the plurality of mass ranges are received, to form respective precursor ions in a respective given mass range. The respective precursor ions are filtered via a mass filter module, a mass scan range of the mass filter module synchronized with the given order in which each of the plurality of mass ranges are received. The respective precursor ions are fragmented, via a fragmentation module, to form respective product ions. The respective product ions are analyzed in a mass spectrometer module to produce product ion spectra.

Abstract translation: 提供了一种用于执行MS / MS的一切的系统和方法。 在质谱仪系统中按照给定的时间顺序接收在多个质量范围内以分子量分级分离的可离子化材料，每个质量范围包括相应的中心质量值和相应的宽度。 可电离材料以给定的顺序电离，以便接收多个质量范围中的每一个，以在相应的给定质量范围内形成相应的前体离子。 通过质量过滤器模块过滤各个前体离子，质量过滤器模块的质量扫描范围与其中接收多个质量范围中的每一个的给定顺序同步。 各自的前体离子通过碎片模块被分段，以形成相应的产物离子。 在质谱仪模块中分析各产物离子以产生产物离子光谱。

公开(公告)号：US20110127418A1

公开(公告)日：2011-06-02

申请号：US12788391

申请日：2010-05-27

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/004 ,  H01J49/4245

Abstract: A mass spectrometer and method for performing high resolution mass spectrometry are provided, the mass spectrometer comprising an electrostatic trap and mass analyzer. The electrostatic trap comprises entrance and exit ends, entrance and exit end ion mirrors, a central field-free region, and a longitudinal axis. The mass analyzer receives ions from the exit end. Ions are admitted into the electrostatic trap via the entrance end, trapping ions in the electrostatic trap, the ions oscillating between the entrance and exit end ion mirrors along the axis. The electrostatic trap waits for the ions to separate into bunches different m/z values via the oscillating, and then excites a given bunch of ions of a given m/z value along the axis until at least a portion of the given bunch overcomes a barrier field at the exit end ion mirror, exiting the electrostatic trap for analysis, leaving behind remaining ions.

Abstract translation: 提供了用于进行高分辨率质谱的质谱仪和方法，该质谱仪包括静电捕集器和质量分析器。 静电捕获器包括入口和出口端，入口和出口端离子反射镜，中心无场区域和纵向轴线。 质量分析仪从出口端接收离子。 离子通过入口端进入静电捕获器，捕获静电捕获器中的离子，离子在入射和离开端离子反射镜之间沿轴线振荡。 静电捕获器等待离子通过振荡分离成不同m / z值的束，然后沿给定的m / z值激发给定的一束离子，直到给定束的至少一部分克服了屏障 在出口端离子反射镜处，离开静电阱进行分析，留下剩余的离子。

公开(公告)号：US20100237236A1

公开(公告)日：2010-09-23

申请号：US12408026

申请日：2009-03-20

Applicant: Bruce Thomson ,  Bruce Collings

Inventor： Bruce Thomson ,  Bruce Collings

IPC: B01D59/44

CPC classification number: H01J49/0045 ,  H01J49/4225 ,  H01J49/427

Abstract: A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.

Abstract translation: 在串联质谱仪中处理多种前体离子的方法包括用离子源生成多个前体离子。 多个前体离子中的至少一些被捕获在离子阱中。 感兴趣的至少两个前体离子与多个前体离子与已滤波的噪声场分离。 感兴趣的前体离子顺序地朝向碰撞池排出。 感兴趣的顺序排出的前体离子在碰撞池中碎裂。 然后用质谱仪测定碎片离子的质荷比谱。

公开(公告)号：US20090101812A1

公开(公告)日：2009-04-23

申请号：US12254244

申请日：2008-10-20

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: B01D59/44

CPC classification number: H01J49/0422 ,  G01N27/624

Abstract: Various embodiments are described herein for an apparatus that can be used to interface a Differential Mobility Analyzer (DMA) with a Mass Spectrometer (MS). The apparatus includes first and second plates with first and second apertures respectively, and an interface region in between the first and second plates. During use, the first aperture receives mobility separated ions from the DMA, the interface region receives a gas flow to prevent gas outflow from the DMA toward the MS, and the first and second plates are configured to receive voltages to generate an electric field there between to guide the mobility separated ions from the first aperture to the second aperture, which then provides the mobility separated ions to the MS.

Abstract translation: 本文描述了可用于将差分移动分析仪（DMA）与质谱仪（MS）接口的装置的各种实施例。 该装置包括分别具有第一和第二孔的第一和第二板以及第一和第二板之间的界面区域。 在使用期间，第一孔径从DMA接收迁移率分离的离子，界面区域接收气流以防止气体从DMA向MS流出，并且第一和第二板被配置为接收电压以在其间产生电场 以将迁移率分离的离子引导到第一孔径到第二孔径，然后将离子离子提供给MS。

公开(公告)号：US20080017789A1

公开(公告)日：2008-01-24

申请号：US11778954

申请日：2007-07-17

Applicant: Jim Hager ,  Bruce Thomson

Inventor： Jim Hager ,  Bruce Thomson

IPC: H01J49/00

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/4265 ,  H01J49/4285

Abstract: A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.

Abstract translation: 提供了具有棒组的操作质谱仪的方法。 杆组具有第一端，与第一端相对的第二端和在第一端和第二端之间延伸的纵向轴线。 该方法包括：a）将离子进入棒组; b）通过以下步骤捕获所述棒组中的至少一些离子：i）在与所述棒组的第一端相邻的第一端构件处产生第一屏障场，ii）在邻近所述杆组的第二端构件处产生第二屏障场 所述杆组的第二端，以及iii）提供包括所述杆组的杆之间的RF场的聚集场; c）选择离子中的第一组离子的第一选择质量与电荷比; d）确定第一组离子的聚集场的选定特征的第一兴奋度; e）将聚集场的所选特征调整到第一兴奋水平以共振地激发第一组离子以质量选择性地从穿过屏障场的棒组中弹出第一组离子; 以及f）在所述激发时间间隔至少为1毫秒的兴奋时间间隔期间将所述聚集场的选定特性保持在所述第一兴奋度水平。

公开(公告)号：US07196327B2

公开(公告)日：2007-03-27

申请号：US10643092

申请日：2003-08-19

Applicant: Bruce Thomson ,  Alexandre V. Loboda

Inventor： Bruce Thomson ,  Alexandre V. Loboda

IPC: H01J49/42

CPC classification number: H01J49/025 ,  H01J49/423 ,  H01J49/4255

Abstract: A mass analyzer for use in a mass spectrometry system comprises an elongate rod set. The rod set has first and second ends and an inscribed circle within the rod set. The radius of the rod set varies from one end of the rod set to the other, so that ions of different mass to charge ratios will become unstable at different locations along the rod set. This characteristic can then be used to cause ejection of ions at different locations along the rod set, in a mass dependent manner. Detectors placed linearly along the rod set can then be used to detect ions and determine the mass of the ions from their ejection locations.

Abstract translation: 用于质谱系统的质量分析器包括细长杆组。 杆组具有第一和第二端以及杆组内的内接圆。 杆组的半径从杆组的一端变为另一端，使得不同质荷比的离子在沿着杆组的不同位置处将变得不稳定。 然后，该特性可以用于以质量依赖的方式沿着杆组在不同位置喷射离子。 然后可以使用沿着杆组线性放置的探测器来检测离子并从其喷射位置确定离子的质量。

公开(公告)号：US20050056778A1

公开(公告)日：2005-03-17

申请号：US10643092

申请日：2003-08-19

Applicant: Bruce Thomson ,  Alexandre Loboda

Inventor： Bruce Thomson ,  Alexandre Loboda

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/025 ,  H01J49/423 ,  H01J49/4255

Abstract: A mass analyzer for use in a mass spectrometry system comprises an elongate rod set. The rod set has first and second ends and an inscribed circle within the rod set. The radius of the rod set varies from one end of the rod set to the other, so that ions of different mass to charge ratios will become unstable at different locations along the rod set. This characteristic can then be used to cause ejection of ions at different locations along the rod set, in a mass dependent manner. Detectors placed linearly along the rod set can then be used to detect ions and determine the mass of the ions from their ejection locations.

Abstract translation: 用于质谱系统的质量分析器包括细长杆组。 杆组具有第一和第二端以及杆组内的内接圆。 杆组的半径从杆组的一端变为另一端，使得不同质荷比的离子在沿着杆组的不同位置处将变得不稳定。 然后，该特性可以用于以质量依赖的方式沿着杆组在不同位置喷射离子。 然后可以使用沿着杆组线性放置的探测器来检测离子并从其喷射位置确定离子的质量。

公开(公告)号：US06784422B2

公开(公告)日：2004-08-31

申请号：US10148888

申请日：2002-12-23

Applicant: Thomas R. Covey ,  Bruce Thomson ,  Charles L. Jolliffe

Inventor： Thomas R. Covey ,  Bruce Thomson ,  Charles L. Jolliffe

IPC: B01D5944

CPC classification number: H01J49/107 ,  H01J49/04 ,  H01J49/067 ,  H01J49/165

Abstract: An interface apparatus, for coupling a plurality of ion source to a mass spectrometer has a plurality of ion sources for generating a plurality of ion beams. An inlet device for passing ion beams into the mass spectrometer is provided as is a device or mechanism for selecting one of the ion beams for passage through into the mass spectrometer and for blocking the other ion beams. An outlet provides a connection to a mass spectrometer. A corresponding method is provided.

Abstract translation: 用于将多个离子源耦合到质谱仪的接口装置具有用于产生多个离子束的多个离子源。 提供了用于将离子束通入质谱仪的入口装置，用于选择离子束中的一个通过到质谱仪中并阻挡其它离子束的装置或机构。 插座提供与质谱仪的连接。 提供了相应的方法。

公开(公告)号：US06285027B1

公开(公告)日：2001-09-04

申请号：US09316388

申请日：1999-05-21

Applicant: Igor Chernushevich ,  Bruce Thomson

Inventor： Igor Chernushevich ,  Bruce Thomson

IPC: H01J4940

CPC classification number: H01J49/421 ,  H01J49/004 ,  H01J49/401

Abstract: There is provided a method of effecting mass analysis on an ion stream, the method comprising passing the ion stream through a first mass resolving spectrometer, to select parent ions having a first desired mass-to-charge ratio. The parent ions are then subject to collision-induced dissociation (CID) to generate fragment ions, and the fragment ions and any remaining parent ions are trapped; the CID and trapping can be carried out together in a linear ion trap. Periodically pulses of the trapped ions are released into a time of flight (TOF) instrument to determine the mass-to-charge ratio of the ions. The delay between the release of the pulses and the initiation of the push-pull pulses of the TOF instrument are adjusted to maximize the duty cycle efficiency and hence the sensitivity for a selected ions with a desired mass-to-charge ratio. This technique can be used to optimize the performance for a parent ion scan, and MRM scan or a neutral loss scan.

Abstract translation: 提供了一种对离子流进行质量分析的方法，该方法包括使离子流通过第一质谱分析光谱仪，以选择具有第一期望的质荷比的母体离子。 然后，母体离子经受碰撞诱导的解离（CID）以产生碎片离子，碎片离子和任何剩余的母体离子被捕获; CID和捕获可以一起在线性离子阱中进行。 捕获的离子的周期脉冲被释放到飞行时间（TOF）仪器中以确定离子的质荷比。 调节脉冲释放和TOF仪器的推挽脉冲启动之间的延迟，以最大化占空比效率，从而使所选离子具有所需质荷比的灵敏度。 该技术可用于优化父离子扫描，MRM扫描或中性损失扫描的性能。

公开(公告)号：US6166378A

公开(公告)日：2000-12-26

申请号：US81552

申请日：1998-05-20

Applicant: Bruce Thomson ,  Igor Chernushevich

Inventor： Bruce Thomson ,  Igor Chernushevich

IPC: H01J49/02 ,  H01J49/06 ,  H01J49/42 ,  H01J49/26

CPC classification number: H01J49/004

Abstract: A method of improving the signal-to-noise using first and second mass spectrometers in tandem, with an ion detector and data system coupled to the second mass spectrometer, comprising selecting precursor ions with the first mass spectrometer, at least some of the parent ions being multiply charged, colliding or reacting the precursor ions in an intermediate chamber so that multiply charged parent ions produce product ions which have at least one fewer charge than the multiply charged precursor ions, and using the second mass spectrometer or the ion detector and data system to allow only those ions which have an m/z value higher than the multiply charged precursor ions to be recorded for analysis by the ion detector and data system, so that only a signal due to multiply charged precursor ions is obtained in said data system.

Abstract translation: 一种使用第一和第二质谱仪串联改善信噪比的方法，其中耦合到第二质谱仪的离子检测器和数据系统包括用第一质谱仪选择前体离子，至少一些母体离子 在中间室中使前体离子多重充电，碰撞或反应，使得多电荷的母体离子产生具有比多电荷前体离子少至少一个电荷的产物离子，并且使用第二质谱仪或离子检测器和数据系统 仅允许具有高于多电荷前体离子的m / z值的那些离子被记录用于由离子检测器和数据系统分析，使得在所述数据系统中仅获得由于多电荷前体离子引起的信号。