公开(公告)号：US06784188B2

公开(公告)日：2004-08-31

申请号：US10370800

申请日：2003-02-20

申请人： Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

发明人： Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC分类号： A61K314745

CPC分类号： C07D471/04 ,  A61K31/4745 ,  Y02A50/409

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06756382B2

公开(公告)日：2004-06-29

申请号：US10027218

申请日：2001-12-21

申请人： Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

发明人： Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC分类号： A61K3144

CPC分类号： C07D471/04 ,  A61K31/4745

摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06716988B2

公开(公告)日：2004-04-06

申请号：US10357777

申请日：2003-02-04

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： C07D213643

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06696465B2

公开(公告)日：2004-02-24

申请号：US10322262

申请日：2002-12-17

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Byron A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Byron A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

摘要翻译： 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06545016B1

公开(公告)日：2003-04-08

申请号：US10165229

申请日：2002-06-07

申请人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

发明人： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC分类号： A61K31437

CPC分类号： C07D471/04

摘要： Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06514985B1

公开(公告)日：2003-02-04

申请号：US09706990

申请日：2000-11-06

申请人： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

发明人： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC分类号： A61K314353

CPC分类号： C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

公开(公告)号：US06440992B1

公开(公告)日：2002-08-27

申请号：US09961738

申请日：2001-09-24

申请人： John F. Gerster ,  Kyle J. Lindstrom ,  Gregory J. Marszalek ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

发明人： John F. Gerster ,  Kyle J. Lindstrom ,  Gregory J. Marszalek ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC分类号： A61K314355

CPC分类号： C07D513/04 ,  C07D513/14 ,  C07D517/04

摘要： Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

摘要翻译： 描述了噻唑并恶唑并[s]噻唑并[4,5-c]喹啉-4-胺及其类似物，包括制造和使用新型中间体的方法。 这些化合物是免疫调节剂并诱导细胞因子生物合成，包括干扰素和/或肿瘤生物合成，坏死因子，并抑制T辅助2型免疫应答。 该化合物还可用于治疗病毒和肿瘤疾病。

公开(公告)号：US06194425B1

公开(公告)日：2001-02-27

申请号：US09210114

申请日：1998-12-11

申请人： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

发明人： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC分类号： C07D47102

CPC分类号： C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

摘要： Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

摘要翻译： 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US6150523A

公开(公告)日：2000-11-21

申请号：US375587

申请日：1999-08-17

申请人： John F. Gerster ,  Kyle J. Lindstrom

发明人： John F. Gerster ,  Kyle J. Lindstrom

IPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/14 ,  C07F9/6561 ,  C07F9/58 ,  C07D471/12

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07F9/6561

摘要： A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.

公开(公告)号：US5693811A

公开(公告)日：1997-12-02

申请号：US669895

申请日：1996-06-21

申请人： Kyle J. Lindstrom

发明人： Kyle J. Lindstrom

IPC分类号： C07D471/04 ,  C07D401/14

CPC分类号： C07D471/04

摘要： A process for preparing 6, 7, 8, 9-tetrahydro-1H-imidazo�4,5-c!quinolin-4-amines is disclosed. The process involves the reduction of a 1H-imidazo�4,5-c!quinolin-4-amine or of a 6H-imidazo�4,5-c!tetrazolo�1,5-a!quinoline.

摘要翻译： 公开了制备6,7,8,9-四氢-1H-咪唑并[4,5-c]喹啉-4-胺的方法。 该方法包括还原1H-咪唑并[4,5-c]喹啉-4-胺或6H-咪唑并[4,5-c]四唑并[1,5-a]喹啉。