摘要:
The present invention discloses fused thienopyridyl compounds of general formula (I) wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
摘要:
This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype α4β2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.
摘要:
A frequency synthesizer. The frequency synthesizer comprises a harmonic locked phase/frequency detector, a low pass filter, a voltage controlled oscillator, and a frequency divider. The harmonic locked phase/frequency detector receives a reference signal and a divided signal. The low pass filter is coupled to the harmonic locked phase/frequency detector. The voltage controlled oscillator is coupled to the low pass filter and provides an output signal. The frequency divider is coupled between the voltage controlled oscillator and the harmonic locked phase/frequency detector. Frequency of the divided signal is a harmonic frequency of the reference signal.
摘要:
A clock data recovery circuit. The clock data recovery circuit comprises a transmission line, a phase locked loop, a voltage controlled oscillator, a phase selector, and a D flip-flop. The transmission line receives an input signal. The phase locked loop receives the input signal via the transmission line and a reference clock and generates a first clock signal. The voltage controlled oscillator receives the input signal via the transmission line and a control voltage from an internal node of the phase locked loop, and generates a clock signal. The phase selector receives the input signal via the transmission line and the clock signal from the voltage controlled oscillator, and generates a clock output signal. The D flip-flop receives the input signal via the transmission line and the clock output signal, and generates a data output signal.
摘要:
A frequency synthesizer. The frequency synthesizer comprises a harmonic locked phase/frequency detector, a low pass filter, a voltage controlled oscillator, and a frequency divider. The harmonic locked phase/frequency detector receives a reference signal and a divided signal. The low pass filter is coupled to the harmonic locked phase/frequency detector. The voltage controlled oscillator is coupled to the low pass filter and provides an output signal. The frequency divider is coupled between the voltage controlled oscillator and the harmonic locked phase/frequency detector. Frequency of the divided signal is a harmonic frequency of the reference signal.
摘要:
The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
摘要:
Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.
摘要翻译:式(I)化合物是可用于治疗疼痛,炎症性热痛觉过敏,尿失禁和膀胱过度活动的新型VR1拮抗剂,其中X 1,X 2,X 2, X 3,X 4,X 5,R 5,R 6,R 6, Z 7,R 8a,R 8b,R 9,Z 1,Z 3, SUB> 2>和L如说明书中所定义。
摘要:
An adapter for antenna on a mobile phone basically is a main body associated with an adapting tube and a cover. A receiving recession is provided between the main body and the cover for containing a wave eliminating plate. The adapting tube is used for fitting with the antenna. The main body has a plurality of through holes for being passed by the rubber forming the adapting tube. The rubber overflowed from each through hole is associated with each other and constitutes a fixing part such that the adapting tube is integrated with the main body. The adapting tube is made of highly elastic and non-brittle rubber and has features such as flexible, free from aging, and durable. Therefore, the adapter is possible to sleeve with any size of antenna on a mobile phone firmly without a phenomenon of being loosened due to elastic fatigue and being damaged due to brittleness after using a period of time.
摘要:
This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype α4β2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.
摘要:
The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.