公开(公告)号：US20110295054A1

公开(公告)日：2011-12-01

申请号：US13104095

申请日：2011-05-10

申请人： Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Lucas B. Elmer ,  Jason L. Harris ,  Christopher J. Hess ,  Jeffrey D. Messerly ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Michael J. Stokes ,  Foster B. Stulen ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Lucas B. Elmer ,  Jason L. Harris ,  Christopher J. Hess ,  Jeffrey D. Messerly ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Michael J. Stokes ,  Foster B. Stulen ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61F2/04 ,  A61M31/00 ,  A61M25/00

CPC分类号： A61F5/005 ,  A61F5/0003 ,  A61F5/0013 ,  A61M25/007 ,  A61M25/04 ,  A61M31/00 ,  A61M37/0015

摘要： Methods described herein involve introducing a nasogastric tube into a patient, connecting the nasogastric tube with a reservoir, anchoring the nasogastric tube with the nasal cavity, and introducing a substance into the reservoir through the nasogastric tube.

摘要翻译： 本文描述的方法包括将鼻胃管引入患者体内，将鼻胃管与储器连接，将鼻胃管与鼻腔固定，并通过鼻胃管将物质引入储液器。

公开(公告)号：US20110295151A1

公开(公告)日：2011-12-01

申请号：US13104282

申请日：2011-05-10

申请人： Gregory J. Bakos ,  Edward G. Chekan ,  Denzel Z. Herrera-Davis ,  Jason L. Harris ,  Gary L. Long ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  David N. Plescia ,  Randy J. Seeley ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Gregory J. Bakos ,  Edward G. Chekan ,  Denzel Z. Herrera-Davis ,  Jason L. Harris ,  Gary L. Long ,  Rudolph H. Nobis ,  Mark S. Ortiz ,  Mark D. Overmyer ,  David N. Plescia ,  Randy J. Seeley ,  William B. Weisenburgh, II ,  Tamara S. Vetro Widenhouse ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M37/00 ,  A61P3/00 ,  A61K9/00 ,  A61F2/04 ,  A61K49/00 ,  A61P3/04 ,  A61B10/02 ,  A61M5/00 ,  A61K35/55 ,  A61K9/20

CPC分类号： C12N5/0679 ,  A61K35/12 ,  A61K35/38 ,  A61L27/14 ,  A61L27/3882 ,  A61L27/58 ,  A61L31/04 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/64

摘要： L-cells may be introduced in the gastrointestinal tract. L-cells are used in the digestive process to produce a more efficient and lasting means of regulating feelings of satiation in a patient. Desired metabolic effects may be achieved by manipulating L-cells via delivery sites, frequency of delivery, or type of biological substance delivered.

摘要翻译： L细胞可能被引入胃肠道。 L细胞用于消化过程，以产生更有效和持久的调节患者饱腹感的手段。 所需的代谢作用可以通过经由递送部位操纵L细胞，递送频率或递送的生物物质的类型来实现。

公开(公告)号：US20080097510A1

公开(公告)日：2008-04-24

申请号：US11469562

申请日：2006-09-01

申请人： Thomas E. Albrecht ,  Mark S. Ortiz ,  David N. Plescia ,  Michael J. Stokes ,  Katherine L. Youmans ,  James W. Voegele ,  Mark S. Zeiner ,  Jason L. Harris

发明人： Thomas E. Albrecht ,  Mark S. Ortiz ,  David N. Plescia ,  Michael J. Stokes ,  Katherine L. Youmans ,  James W. Voegele ,  Mark S. Zeiner ,  Jason L. Harris

IPC分类号： A61M29/02

CPC分类号： A61F5/0003 ,  A61F5/0036

摘要： A method for inducing weight loss with a patient, using the step of providing an implant for placement within the stomach wherein the implant is a member having an undeployed shape for delivery to the stomach and a deployed shape for implantation therein. The method also involves the step of delivering the member to the stomach while in its undeployed shape. The method further involves the step of exerting an outward force against an interior of the stomach so as to bring together two substantially opposing surfaces of the hollow body by placing the member in its deployed position.

摘要翻译： 一种利用患者引入体重减轻的方法，使用提供用于放置在胃内的植入物的步骤，其中所述植入物是具有用于输送到胃的未部署形状的部件和用于植入其中的展开形状。 该方法还包括在未部署形状的同时将构件递送到胃的步骤。 该方法还包括向胃内部施加向外力的步骤，以便通过将构件放置在其展开位置而将中空体的两个基本上相对的表面组合在一起。

公开(公告)号：US20080058840A1

公开(公告)日：2008-03-06

申请号：US11469564

申请日：2006-09-01

申请人： Thomas E. Albrecht ,  Mark S. Ortiz ,  David N. Plescia ,  Michael J. Stokes ,  Katherine L. Youmans ,  James W. Voegele ,  Mark S. Zeiner ,  Jason L. Harris

发明人： Thomas E. Albrecht ,  Mark S. Ortiz ,  David N. Plescia ,  Michael J. Stokes ,  Katherine L. Youmans ,  James W. Voegele ,  Mark S. Zeiner ,  Jason L. Harris

IPC分类号： A61B17/08

CPC分类号： A61F5/0036 ,  A61B17/08 ,  A61B17/083

摘要： An implant for placement within a hollow body organ. The implant includes a member having an undeployed shape for delivery to the hollow body and a deployed shape for implantation therein. The member has sufficient rigidity in its deployed shape to exert an outward force against an interior of the hollow body so as to bring together two substantially opposing surfaces of the hollow body.

摘要翻译： 用于放置在中空身体器官内的植入物。 植入物包括具有用于输送到中空体的未展开形状的部件和用于植入其中的展开形状。 该构件在其展开形状上具有足够的刚度以向中空体的内部施加向外的力，以将中空体的两个基本相对的表面组合在一起。

公开(公告)号：US20120165792A1

公开(公告)日：2012-06-28

申请号：US12976648

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  Mark S. Zeiner ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Daniel James Prenger

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  Mark S. Zeiner ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Daniel James Prenger

IPC分类号： A61M37/00

CPC分类号： A61M31/002 ,  A61B1/00147 ,  A61B1/041 ,  A61B5/07 ,  A61B5/4839

摘要： Devices and related methods arc provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete. administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

摘要翻译： 提供了设备和相关方法，用于将治疗剂控制递送到身体内的目标位置。 更具体地，提供了用于控制经口给药的药丸通过身体的速率的方法和装置，以及用于控制体内在特定位置处的丸剂内的治疗剂的递送。 提供了在本文中通常被称为“捕获器”的各种类型的装置，其可以在通过身体时主动地捕捉药丸。 捕手可以将药丸保持在身体内的特定位置，直到发生预定事件，例如部分或完全。 给药丸内的治疗剂。 然后，捕手可以在命令和/或发生预定事件时释放药片以允许药丸从身体中流出。 在其他实施例中，提供了可以主动地接合捕获器并保持与捕获器接合的各种类型的药丸，直到发生预定事件。

公开(公告)号：US20100023022A1

公开(公告)日：2010-01-28

申请号：US12179604

申请日：2008-07-25

申请人： Mark S. Zeiner ,  Jason L. Harris ,  Michael J. Stokes ,  Matthew D. Holcomb ,  Mark S. Ortiz ,  Lawrence Crainich ,  Alex P. Kondor

发明人： Mark S. Zeiner ,  Jason L. Harris ,  Michael J. Stokes ,  Matthew D. Holcomb ,  Mark S. Ortiz ,  Lawrence Crainich ,  Alex P. Kondor

IPC分类号： A61B17/10

CPC分类号： A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0493 ,  A61B17/3498 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/003 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00818 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2916 ,  A61B2017/292 ,  A61B2017/2923 ,  A61B2050/3015

摘要： A cartridge containing a fastener. The cartridge has an elongated sheath containing at least one tissue penetrating member. The penetrating member at least partially houses a fastener. The fastener has at least two anchors connected together by a non-resilient flexible suture which does not resist deformation under compressible loads. The cartridge further includes a means for deploying the anchors, wherein the means is movable within the sheath.

摘要翻译： 包含紧固件的墨盒。 盒具有包含至少一个组织穿透构件的细长护套。 穿透构件至少部分地容纳紧固件。 紧固件具有至少两个通过非弹性柔性缝合线连接在一起的锚固件，其在可压缩载荷下不会抵抗变形。 墨盒还包括用于展开锚固件的装置，其中该装置可在护套内移动。

公开(公告)号：US20120165794A1

公开(公告)日：2012-06-28

申请号：US12976761

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

IPC分类号： A61M31/00

CPC分类号： A61B1/041 ,  A61B1/00147 ,  A61F5/0013 ,  A61M31/002

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

公开(公告)号：US20120165793A1

公开(公告)日：2012-06-28

申请号：US12976745

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  James W. Voegele ,  William B. Weisenburgh, II ,  Rudolph H. Nobis ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Darrel M. Powell ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Jeremy David Jarrett ,  Daniel James Prenger ,  Matthew D. Rohr Daniel

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James T. Spivey ,  Michael J. Stokes ,  Thomas E. Albrecht ,  James W. Voegele ,  William B. Weisenburgh, II ,  Rudolph H. Nobis ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Darrel M. Powell ,  Joseph Bernard Kraimer ,  James Anthony Topich ,  Jeremy David Jarrett ,  Daniel James Prenger ,  Matthew D. Rohr Daniel

IPC分类号： A61K9/22

CPC分类号： A61M31/002 ,  A61B1/041

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

摘要翻译： 提供了设备和相关方法，用于将治疗剂控制递送到身体内的目标位置。 更具体地，提供了用于控制经口给药的药丸通过身体的速率的方法和装置，以及用于控制体内在特定位置处的丸剂内的治疗剂的递送。 提供了在本文中通常被称为“捕获器”的各种类型的装置，其可以在通过身体时主动地捕捉药丸。 捕获器可以将药丸保持在体内的特定位置，直到发生预定事件，例如在丸中部分或完全施用治疗剂。 然后，捕手可以在命令和/或发生预定事件时释放药片以允许药丸从身体中流出。 在其他实施例中，提供了可以主动地接合捕获器并保持与捕获器接合的各种类型的药丸，直到发生预定事件。

公开(公告)号：US20120080495A1

公开(公告)日：2012-04-05

申请号：US13325536

申请日：2011-12-14

申请人： Matthew D. Holcomb ,  Jason L. Harris ,  Michael J. Stokes ,  Mark S. Zeiner ,  Mark S. Ortiz ,  Alexander P. Kondor ,  Lawrence Crainich ,  Eugene L. Timperman

发明人： Matthew D. Holcomb ,  Jason L. Harris ,  Michael J. Stokes ,  Mark S. Zeiner ,  Mark S. Ortiz ,  Alexander P. Kondor ,  Lawrence Crainich ,  Eugene L. Timperman

IPC分类号： A61B17/068

CPC分类号： A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/3498 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2916 ,  A61B2017/2917 ,  A61B2017/292 ,  A61B2017/2923 ,  A61B2017/2926

摘要： A device for deploying fasteners including a handle and at least one actuator. The handle is connected to an elongated hollow housing having distal and proximal ends. The device has a first cartridge containing at least one fastener releasably connectable to the handle. The device also includes an elongated pusher movable through the hollow housing from the proximal to the distal end to deploy the fasteners. The device further includes a deforming member for deforming the pusher at a proximal end thereof while advancing the pusher to the distal end of the housing.

摘要翻译： 一种用于展开紧固件的装置，包括手柄和至少一个致动器。 手柄连接到具有远端和近端的细长的中空壳体。 该装置具有容纳可释放地连接到手柄的至少一个紧固件的第一盒。 该装置还包括细长的推动器，其可从近端到远端移动穿过中空壳体以展开紧固件。 该装置还包括变形构件，用于使推动器在其近端处变形，同时将推动器推进到壳体的远端。

公开(公告)号：US20100023026A1

公开(公告)日：2010-01-28

申请号：US12179605

申请日：2008-07-25

申请人： Mark S. Zeiner ,  Jason L. Harris ,  Michael J. Stokes ,  Matthew D. Holcomb ,  Mark S. Ortiz ,  Lawrence Crainich ,  Alex P. Kondor

发明人： Mark S. Zeiner ,  Jason L. Harris ,  Michael J. Stokes ,  Matthew D. Holcomb ,  Mark S. Ortiz ,  Lawrence Crainich ,  Alex P. Kondor

IPC分类号： A61B17/04

CPC分类号： A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0493 ,  A61B17/3498 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00818 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2916 ,  A61B2017/292 ,  A61B2017/2923

摘要： A reloadable device for deploying fasteners. The device has a handle and at least one actuator. The handle is connected to an elongated hollow housing having distal and proximal ends. The device includes a first cartridge containing at least one fastener releasably connectable to the handle. The fastener has at least two anchors connected together by a non-resilient flexible suture which does not resist deformation under compressible loads. The first cartridge is removable from the handle. The device includes a second cartridge having at least one fastener releasably connectable to the handle after removal of the first cartridge. The second cartridge being insertable into the device from a proximal end thereof.

摘要翻译： 用于部署紧固件的可重装装置。 该装置具有手柄和至少一个致动器。 手柄连接到具有远端和近端的细长的中空壳体。 该装置包括容纳可释放地连接到手柄的至少一个紧固件的第一盒。 紧固件具有至少两个通过非弹性柔性缝合线连接在一起的锚固件，其在可压缩载荷下不会抵抗变形。 第一个墨盒可从手柄上取下。 该装置包括具有至少一个紧固件的第二盒，该至少一个紧固件在移除第一盒之后可释放地连接到手柄。 第二盒可从其近端插入到装置中。