公开(公告)号：US20060073561A1

公开(公告)日：2006-04-06

申请号：US10986405

申请日：2004-11-12

申请人： Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

发明人： Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

IPC分类号： A61K38/17 ,  C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20050214786A1

公开(公告)日：2005-09-29

申请号：US10921235

申请日：2004-08-19

申请人： Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Henrik Olsen ,  Jian Ni ,  Kevin Baker ,  Craig Rosen ,  Steven Ruben ,  Michele Fiscella ,  Paul Moore ,  Ping Wei

发明人： Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Henrik Olsen ,  Jian Ni ,  Kevin Baker ,  Craig Rosen ,  Steven Ruben ,  Michele Fiscella ,  Paul Moore ,  Ping Wei

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N9/00 ,  C12Q1/68

CPC分类号： C07H21/04 ,  C07K14/47 ,  C12Q1/6883

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060057582A1

公开(公告)日：2006-03-16

申请号：US10644807

申请日：2003-08-21

申请人： Craig Rosen ,  George Komatsoulis ,  Charles Birse ,  Gil Choi ,  Henrik Olsen ,  Jian Ni ,  Adam Bell

发明人： Craig Rosen ,  George Komatsoulis ,  Charles Birse ,  Gil Choi ,  Henrik Olsen ,  Jian Ni ,  Adam Bell

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US20050064458A1

公开(公告)日：2005-03-24

申请号：US10863332

申请日：2004-06-09

申请人： Craig Rosen ,  Steven Ruben ,  Paul Moore ,  Paul Young ,  George Komatsoulis ,  Charles Birse ,  Roxanne Duan ,  Kimberly Florence ,  Daniel Soppet

发明人： Craig Rosen ,  Steven Ruben ,  Paul Moore ,  Paul Young ,  George Komatsoulis ,  Charles Birse ,  Roxanne Duan ,  Kimberly Florence ,  Daniel Soppet

IPC分类号： G01N33/53 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/04 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P9/10 ,  A61P11/06 ,  A61P17/02 ,  A61P17/06 ,  A61P17/12 ,  A61P19/02 ,  A61P25/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/566 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050181371A1

公开(公告)日：2005-08-18

申请号：US10644765

申请日：2003-08-21

申请人： Craig Rosen ,  George Komatsoulis ,  Kevin Baker ,  Michele Fiscella ,  Paul Moore ,  Ping Wei ,  D. Duan ,  Yanggu Shi ,  Ram Gupta

发明人： Craig Rosen ,  George Komatsoulis ,  Kevin Baker ,  Michele Fiscella ,  Paul Moore ,  Ping Wei ,  D. Duan ,  Yanggu Shi ,  Ram Gupta

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070048818A1

公开(公告)日：2007-03-01

申请号：US10868184

申请日：2004-06-16

申请人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

发明人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。