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    WT1 Vaccine
    22.
    发明申请
    WT1 Vaccine 审中-公开
    WT1疫苗

    公开(公告)号：US20150328298A1

    公开(公告)日：2015-11-19

    申请号：US14651492

    申请日：2013-12-13

    申请人： David B. WEINER ,  Jian YAN ,  Jewell WALTERS ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC.

    发明人： David B. Weiner ,  Jian Yan ,  Jewell Walters

    IPC分类号： A61K39/00 ,  C07K14/47

    CPC分类号： A61K39/0011 ,  A61K2039/53 ,  C07K14/4748

    摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

    摘要翻译： 本文公开了包含编码突变的WT1抗原的一个或多个核酸序列的核酸分子。 公开了包含编码突变的WT1抗原的一个或多个核酸序列的载体，组合物和疫苗。 公开了治疗具有WT1表达肿瘤的个体的方法和预防表达WT1的肿瘤的方法。 公开了突变的WT1抗原。

    HPV vaccines and methods for using the same
    24.
    发明授权
    HPV vaccines and methods for using the same 有权
    HPV疫苗及其使用方法

    公开(公告)号：US08168769B2

    公开(公告)日：2012-05-01

    申请号：US12375518

    申请日：2007-07-30

    申请人： David B Weiner ,  Jian Yan

    发明人： David B Weiner ,  Jian Yan

    IPC分类号： C12N15/11 ,  C12N15/63

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55538 ,  A61K2039/585 ,  C12N7/00 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2760/16134 ,  C12N2770/24234

    摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

    摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子，所公开的免疫原包括具有HIV亚型A包膜蛋白共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，具有HIV亚型C包膜蛋白的共有序列的那些 具有HIV亚型D包膜蛋白共有序列的那些，具有HIV亚型共有序列Nef-Rev蛋白的共有序列的那些，以及具有共有序列的那些序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和 编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并且公开了改进的抗流感免疫原和编码它们的核酸分子。 公开了药物组合物，包含和减毒病原体的重组疫苗，以及诱导个体对HIV，HPV，HCV，hTERT和流感的免疫应答的方法。